4-Formylphenoxyacetic acid
- Product Name
- 4-Formylphenoxyacetic acid
- CAS No.
- 22042-71-3
- Chemical Name
- 4-Formylphenoxyacetic acid
- Synonyms
- 4-Formyl-PAA;AKOS B004256;AKOS AU36-M42;ASISCHEM R21550;4-FORMYL-PAA LINKER;4-FORMYLPHENOXYACETIC ACID;P-FORMYLPHENOXYACETIC ACID;(4-formylphenoxy)-aceticaci;4-FormylphenoxyaceticAcid>2-(4-formylphenoxy)aceticaci
- CBNumber
- CB3114243
- Molecular Formula
- C9H8O4
- Formula Weight
- 180.16
- MOL File
- 22042-71-3.mol
4-Formylphenoxyacetic acid Property
- Melting point:
- 193-196 °C
- Boiling point:
- 272.96°C (rough estimate)
- Density
- 1.2933 (rough estimate)
- refractive index
- 1.4500 (estimate)
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- Soluble in hot methanol within almost transparency.
- form
- Crystalline Powder
- pka
- 3.04±0.10(Predicted)
- color
- Beige
- Sensitive
- Air Sensitive
- BRN
- 779885
- InChI
- InChI=1S/C9H8O4/c10-5-7-1-3-8(4-2-7)13-6-9(11)12/h1-5H,6H2,(H,11,12)
- InChIKey
- OYNIIKHNXNPSAG-UHFFFAOYSA-N
- SMILES
- C(O)(=O)COC1=CC=C(C=O)C=C1
- CAS DataBase Reference
- 22042-71-3(CAS DataBase Reference)
- EPA Substance Registry System
- Acetic acid, (4-formylphenoxy)- (22042-71-3)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36
- WGK Germany
- 3
- TSCA
- Yes
- HazardClass
- IRRITANT
- HS Code
- 29189900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- F0319
- Product name
- 4-Formylphenoxyacetic Acid
- Purity
- >97.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $178
- Updated
- 2021/12/16
- Product number
- F701503
- Product name
- 2-(4-Formylphenoxy)aceticAcid
- Packaging
- 2.5g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- Z1607
- Product name
- p-Formylphenoxyaceticacid
- Packaging
- 1g
- Price
- $14
- Updated
- 2021/12/16
- Product number
- Z1607
- Product name
- p-Formylphenoxyaceticacid
- Packaging
- 5g
- Price
- $41
- Updated
- 2021/12/16
- Product number
- OR930525
- Product name
- 4-Formylphenoxyacetic Acid
- Purity
- 98%
- Packaging
- 5g
- Price
- $109
- Updated
- 2021/12/16
4-Formylphenoxyacetic acid Chemical Properties,Usage,Production
Chemical Properties
BEIGE CRYSTALLINE POWDER
Uses
4-Formylphenoxyacetic acid is used as an organic chemical synthesis intermediate.
General Description
4-Formylphenoxyacetic acid is a formylphenoxyaliphatic acid that reacts with dimedone to form 1,8-dioxo-octahydroxanthenes. It participates in the synthesis of 4-substituted benzaldehyde derivatives and 4-carboxypheoxyacetic acid.
Synthesis
123-08-0
79-08-3
22042-71-3
The general procedure for the synthesis of 2-(4-formylphenoxy)acetic acid from p-hydroxybenzaldehyde and bromoacetic acid was as follows: potassium carbonate (24.9 g, 180.0 mmol) was added to a solution of 4-hydroxybenzaldehyde (10.0 g, 82.0 mmol) in acetone (150 mL) and the reaction mixture was stirred for 15 min at 40 °C. Subsequently, bromoacetic acid (12.0 g, 86.0 mmol) was added slowly in batches and the reaction mixture was heated to reflux for 18 hours. After completion of the reaction, the reaction mixture was cooled and diluted by adding water (200 mL). The reaction mixture was extracted with ethyl acetate (2 x 200 mL) and after combining the organic phases, the aqueous layer was adjusted to pH 2 with 6N hydrochloric acid. the aqueous layer was again extracted with ethyl acetate (2 x 400 mL), the organic phases were combined and washed with water (200 mL), dried with anhydrous sodium sulfate and finally concentrated under vacuum. The residue was ground with isohexane to afford the target compound 2-(4-formylphenoxy)acetic acid (13.5 g, 91% yield) as a creamy white solid.1H NMR (d6-DMSO) δ: 13.12 (br s, 1H), 9.87 (s, 1H), 7.88-7.85 (m, 2H), 7.12-7.10 (m, 2H). 4.83 (s, 2H).
References
[1] Patent: WO2015/86509, 2015, A1. Location in patent: Page/Page column 92; 93
[2] Main Group Metal Chemistry, 2015, vol. 38, # 5-6, p. 157 - 164
[3] Patent: WO2004/89945, 2004, A1. Location in patent: Page 8
[4] European Journal of Medicinal Chemistry, 2015, vol. 95, p. 230 - 239
4-Formylphenoxyacetic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Formylphenoxyacetic acid manufacturers
- Product
- 4-Formylphenoxyacetic acid 22042-71-3
- Price
- US $3.00-9.00/KG
- Min. Order
- 0.1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2025-06-19
- Product
- 2-(4-formylphenoxy)acetic acid 22042-71-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-12-25