ChemicalBook > CAS DataBase List > 4-Formylphenoxyacetic acid

4-Formylphenoxyacetic acid

Product Name: 4-Formylphenoxyacetic acid
CAS No.: 22042-71-3
Chemical Name: 4-Formylphenoxyacetic acid
Synonyms: 4-Formyl-PAA;AKOS B004256;AKOS AU36-M42;ASISCHEM R21550;4-FORMYL-PAA LINKER;4-FORMYLPHENOXYACETIC ACID;P-FORMYLPHENOXYACETIC ACID;(4-formylphenoxy)-aceticaci;4-FormylphenoxyaceticAcid>2-(4-formylphenoxy)aceticaci
CBNumber: CB3114243
Molecular Formula: C9H8O4
Formula Weight: 180.16
MOL File: 22042-71-3.mol

Less

4-Formylphenoxyacetic acid Property

Melting point:: 193-196 °C
Boiling point:: 272.96°C (rough estimate)
Density: 1.2933 (rough estimate)
refractive index: 1.4500 (estimate)
storage temp.: Inert atmosphere,2-8°C
solubility: Soluble in hot methanol within almost transparency.
form: Crystalline Powder
pka: 3.04±0.10(Predicted)
color: Beige
Sensitive: Air Sensitive
BRN: 779885
InChI: InChI=1S/C9H8O4/c10-5-7-1-3-8(4-2-7)13-6-9(11)12/h1-5H,6H2,(H,11,12)
InChIKey: OYNIIKHNXNPSAG-UHFFFAOYSA-N
SMILES: C(O)(=O)COC1=CC=C(C=O)C=C1
CAS DataBase Reference: 22042-71-3(CAS DataBase Reference)
EPA Substance Registry System: Acetic acid, (4-formylphenoxy)- (22042-71-3)

Less

Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-36/37/38
Safety Statements: 26-36
WGK Germany: 3
TSCA: Yes
HazardClass: IRRITANT
HS Code: 29189900

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: F0319
Product name: 4-Formylphenoxyacetic Acid
Purity: >97.0%(HPLC)(T)
Packaging: 25g
Price: $178
Updated: 2021/12/16

TRC

Product number: F701503
Product name: 2-(4-Formylphenoxy)aceticAcid
Packaging: 2.5g
Price: $75
Updated: 2021/12/16

AK Scientific

Product number: J96488
Product name: p-Formylphenoxyaceticacid
Packaging: 100g
Price: $280
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0011743
Product name: 4-FORMYLPHENOXYACETIC ACID
Purity: 95.00%
Packaging: 0.5G
Price: $605
Updated: 2021/12/16

Apolloscientific

Product number: OR930525
Product name: 4-Formylphenoxyacetic Acid
Purity: 98%
Packaging: 100g
Price: $646
Updated: 2021/12/16

Less

4-Formylphenoxyacetic acid Chemical Properties,Usage,Production

Chemical Properties

BEIGE CRYSTALLINE POWDER

Uses

4-Formylphenoxyacetic acid is used as an organic chemical synthesis intermediate.

General Description

4-Formylphenoxyacetic acid is a formylphenoxyaliphatic acid that reacts with dimedone to form 1,8-dioxo-octahydroxanthenes. It participates in the synthesis of 4-substituted benzaldehyde derivatives and 4-carboxypheoxyacetic acid.

Synthesis

123-08-0

79-08-3

22042-71-3

The general procedure for the synthesis of 2-(4-formylphenoxy)acetic acid from p-hydroxybenzaldehyde and bromoacetic acid was as follows: potassium carbonate (24.9 g, 180.0 mmol) was added to a solution of 4-hydroxybenzaldehyde (10.0 g, 82.0 mmol) in acetone (150 mL) and the reaction mixture was stirred for 15 min at 40 °C. Subsequently, bromoacetic acid (12.0 g, 86.0 mmol) was added slowly in batches and the reaction mixture was heated to reflux for 18 hours. After completion of the reaction, the reaction mixture was cooled and diluted by adding water (200 mL). The reaction mixture was extracted with ethyl acetate (2 x 200 mL) and after combining the organic phases, the aqueous layer was adjusted to pH 2 with 6N hydrochloric acid. the aqueous layer was again extracted with ethyl acetate (2 x 400 mL), the organic phases were combined and washed with water (200 mL), dried with anhydrous sodium sulfate and finally concentrated under vacuum. The residue was ground with isohexane to afford the target compound 2-(4-formylphenoxy)acetic acid (13.5 g, 91% yield) as a creamy white solid.1H NMR (d6-DMSO) δ: 13.12 (br s, 1H), 9.87 (s, 1H), 7.88-7.85 (m, 2H), 7.12-7.10 (m, 2H). 4.83 (s, 2H).

References

[1] Patent: WO2015/86509, 2015, A1. Location in patent: Page/Page column 92; 93
[2] Main Group Metal Chemistry, 2015, vol. 38, # 5-6, p. 157 - 164
[3] Patent: WO2004/89945, 2004, A1. Location in patent: Page 8
[4] European Journal of Medicinal Chemistry, 2015, vol. 95, p. 230 - 239

4-Formylphenoxyacetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

Less

4-Formylphenoxyacetic acid Suppliers

Americas 1 Belgium 2 China 98 Europe 1 Finland 1 France 2 Germany 8 India 9 Japan 2 Russia 1 Switzerland 3 United Kingdom 7 United States 22 Global 157

Changzhou Yinghao Technology Development Co., Ltd

Tel: 15151934985
Email: sales@yingsapharm.com
Country: China
ProdList: 5181
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 15883
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Shandong Xiya Chemical Co., Ltd

Tel: 4009903999 13355009207
Fax: 0539-6365991
Email: 3007715519@qq.com
Country: China
ProdList: 18729
Advantage: 57

Syntechem Co.,Ltd

Tel
Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12984
Advantage: 57

Sinopharm Chemical Reagent Co,Ltd.

Tel: 86-21-63210123
Fax: 86-21-63290778 86-21-63218885
Email: sj_scrc@sinopharm.com
Country: China
ProdList: 9815
Advantage: 79

Maya High Purity Chemicals

Tel: +86 (573) 82222445 (0)18006601000 452520369
Fax: +86 (573) 82222643
Email: sales@maya-r.com
Country: China
ProdList: 11707
Advantage: 57

Wuhan TCASChem Technology Co., Ltd.

Tel: 027-86697669 13986148687
Fax: 86-027-86697669
Email: sales@tcaschem.com
Country: China
ProdList: 3991
Advantage: 55

Thermo Fisher Scientific

Tel: 800-810-5118
Fax: +86-10-84193589
Email: cnchemical@thermofisher.com
Country: China
ProdList: 17770
Advantage: 75

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66113011 17798518460
Fax: (1)02557626880
Email: cfzhang@aikonchem.com
Country: China
ProdList: 19913
Advantage: 55

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

Shanghai Arbor Chemical Co., Ltd.

Tel: 021-60451683 15021268886
Fax: +86-21-60451682
Email: sales@arborchemical.com
Country: China
ProdList: 896
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51395
Advantage: 80

Zhengzhou Guancheng Laboratory equipment Sales

Tel: 0371-88888888 272369594
Fax: QQ:272369594
Email: 2723695949@qq.com
Country: China
ProdList: 4958
Advantage: 50

Henan CoreyChem Co., Ltd

Tel: 0371-86658258
Fax: 0371-60996044
Email: info@coreychem.com
Country: China
ProdList: 10453
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

parabiochem

Tel: 025-83453382-8005
Fax: 025-83453382
Email: sale@parabiochem.com
Country: China
ProdList: 9595
Advantage: 55

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

MQ (shanghai) Pharmaceuticals Co., Ltd.

Tel: 13761635123
Fax: 1014988033@qq
Email: 1014988033@qq.com
Country: China
ProdList: 4941
Advantage: 55

Shanghai Zhen Li Biological Technology Co., Ltd

Tel: 021-16621358918; 18516310516
Fax: 13045646768
Email: zhenlipharma888@163.com
Country: China
ProdList: 19035
Advantage: 58

Rhawn Reagent

Tel: 400-400-1332688 18019345275
Fax: 400-133-2688
Email: amy@rhawn.cn
Country: China
ProdList: 14948
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 400821072
Fax: 021-58955996
Email: malulu@leyan.com
Country: China
ProdList: 25000
Advantage: 58

Chengdu Saint - Kay Biotechnology Co., Ltd.

Tel: 028-85157043 15882256948
Email: 676046971@qq.com
Country: China
ProdList: 4181
Advantage: 58

Institute of Petrochemistry, Heilongjiang Academy of Sciences

Tel: 13804518015
Fax: 0451-82639376
Email: longhaicao@sohu.com
Country: China
ProdList: 59
Advantage: 58

Jinan Liheng Biotechnology Co., Ltd.

Tel: 0531-18763987518 18763987518
Email: levi@lihengpharm.com
Country: China
ProdList: 1797
Advantage: 58

Zhengzhou Acme Chemical Co., Ltd.

Tel: 0371-63315541 13323832564
Fax: QQ:3001332135
Email: 3001332135@qq.com
Country: China
ProdList: 9972
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

Beijing Minruida Technology Co., Ltd.

Tel: 010-82387566 18001021521;
Fax: 82387566-801
Email: sales@mreda.com.cn
Country: China
ProdList: 10083
Advantage: 58

Henan Alfa Chemical Co., Ltd

Tel: +8615838112936
Email: alfa10@alfachem.cn
Country: China
ProdList: 12921
Advantage: 58

ANHUI WITOP BIOTECH CO., LTD

Tel: +8615255079626
Email: eric@witopchemical.com
Country: China
ProdList: 23541
Advantage: 58

Zhejiang J&C Biological Technology Co.,Limited

Tel: +1-2135480471
Email: sales@sarms4muscle.com
Country: China
ProdList: 10473
Advantage: 58

sgtlifesciences pvt ltd

Tel: +8617013299288
Email: dj@sgtlifesciences.com
Country: China
ProdList: 12373
Advantage: 58

Dayang Chem (Hangzhou) Co.,Ltd.

Tel: +86-0571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: China
ProdList: 52846
Advantage: 58

Zhengzhou Edward Biology Co.,Ltd

Tel: 0371-63682289 15538176268
Fax: QQ：1875164801
Email: jacschem@163.com
Country: China
ProdList: 9926
Advantage: 58

Chongqing Chemdad Co., Ltd

Tel: +86-023-6139-8061 +86-86-13650506873
Email: sales@chemdad.com
Country: China
ProdList: 39927
Advantage: 58

CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
Email: sales@conier.com
Country: China
ProdList: 49975
Advantage: 58

Yuzhou Enthalpy Carbon Pharmaceutical Technology Co. LTD

Tel: 19963477321; 19963477321
Fax: QQ:2041275825
Email: 2041275825@qq.com
Country: China
ProdList: 1447
Advantage: 58

CHG Opto-Electronic Corporation Limited

Tel: 2537653158 16621191650
Fax: QQ 2537653158
Email: 2537653158@qq.com
Country: China
ProdList: 7301
Advantage: 58

Shanghai Fine Biotech Co.，Ltd

Tel: 18717800556
Email: sales@finebiotech.com
Country: China
ProdList: 2182
Advantage: 58

Henan Weitesi Chemical Technology Co. LTD

Tel: 0371-0371-55135753 18003832934
Fax: QQ：2853979818
Email: 2853979818@qq.com
Country: China
ProdList: 9991
Advantage: 58

CHANGZHOU GARDE PHARMTECH CO.,LTD

Tel: 18006124028
Email: gardepharm@163.com
Country: China
ProdList: 117
Advantage: 58

Krain Pharmaceutical Technology CO.,Ltd

Tel: 18252089365
Email: Krain_kerun@163.com
Country: China
ProdList: 2507
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: 029-81124267 17392282731
Fax: 029-88380327
Email: 1073@dideu.com
Country: China
ProdList: 9992
Advantage: 58

Less

View Lastest Price from 4-Formylphenoxyacetic acid manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 4-Formylphenoxyacetic acid 22042-71-3
Price: US $3.00-9.00/KG
Min. Order: 0.1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2025-06-19

Career Henan Chemical Co

Product: 2-(4-formylphenoxy)acetic acid 22042-71-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2018-12-25

22042-71-3, 4-Formylphenoxyacetic acidRelated Search:

4-Methoxybenzyl alcohol m-Anisyl alcohol Methyl methoxyacetate p-Anisaldehyde Phenoxyacetic acid (Trifluoromethoxy)benzene Anisole 4-Methoxyphenylacetic acid Ethyl 2-(Chlorosulfonyl)acetate 4-Methoxybenzoic acid Methoxyacetic acid Ascoric Acid 4-ACETYLPHENOXYACETIC ACID R(+)-IAA-94 Ethacrynic acid efloxate 4-CARBOXYPHENOXYACETIC ACID Phenylacetic acid

4-FORMYLPHENOXYACETIC ACID

4-Formyl-PAA

4-Formylphenoxyacetic acid,99%

4-Formylphenoxyacetic acid >=97.0% (T)

ASISCHEM R21550

AKOS AU36-M42

AKOS B004256

4-FORMYL-PAA LINKER

(4-formylphenoxy)-aceticaci

P-FORMYLPHENOXYACETIC ACID

4-FormylphenoxyaceticAcid&gt

Acetic acid, 2-(4-formylphenoxy)-

2-(4-formylphenoxy)aceticaci

4-Formylphenoxyacetic acid-98%

22042-71-3

CARBOXYLIC ACID

Analytical Chromatography Product Catalog

Alphabetic

FM - FZ

Analytical Standards

Phenoxyacetic Acids and Alcohols (substituted)

Alphabetic

Analytical Standards

Analytical/Chromatography

Building Blocks

Carbonyl Compounds

Chemical Synthesis

FM - FZ

Organic Building Blocks

Aldehydes

C9Alphabetic

Carbonyl Compounds

FM - FZ