ChemicalBook > CAS DataBase List > D-ASPARTIC ACID-BETA-METHYL ESTER

D-ASPARTIC ACID-BETA-METHYL ESTER

Product Name
D-ASPARTIC ACID-BETA-METHYL ESTER
CAS No.
21394-81-0
Chemical Name
D-ASPARTIC ACID-BETA-METHYL ESTER
Synonyms
D-Asp(Ome).HCl;D-Asp(OMe)-OH·HCl;H-D-Aspartic acid-;Asparagine Impurity 24;D-ASPARTICACID-β-METHYLESTER;β-Methyl (2R)-aspartate ester;D-Aspartic acid-β-methyl ester;H-D-Aspartic acid-β-methyl ester;D-ASPARTIC ACID-BETA-METHYL ESTER;H-D-ASPARTIC ACID-SS-METHYL ESTER
CBNumber
CB7191668
Molecular Formula
C5H9NO4
Formula Weight
147.13
MOL File
21394-81-0.mol
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D-ASPARTIC ACID-BETA-METHYL ESTER Property

Melting point:
188-190 °C
Boiling point:
301.7±37.0 °C(Predicted)
Density 
1.299
storage temp. 
Sealed in dry,Room Temperature
pka
2.16±0.23(Predicted)
Appearance
White to off-white Solid
optical activity
23.2°(C=1.00g/100ml MEOH)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Chem-Impex
Product number
05942
Product name
D-Asparticacidβ-methylesterhydrochloride,99%(Assay)
Purity
99%(Assay)
Packaging
1G
Price
$72.8
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA48674
Product name
D-Aspartic acid beta-methyl ester hydrochloride
Packaging
500mg
Price
$95
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
AAA0003800
Product name
D-ASPARTIC ACID-BETA-METHYL ESTER
Purity
95.00%
Packaging
5G
Price
$179.55
Updated
2021/12/16
AK Scientific
Product number
V1600
Product name
D-Asparticacid-beta-methylester
Packaging
25g
Price
$235
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA48674
Product name
D-Aspartic acid beta-methyl ester hydrochloride
Packaging
2g
Price
$260
Updated
2021/12/16
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D-ASPARTIC ACID-BETA-METHYL ESTER Chemical Properties,Usage,Production

Definition

ChEBI: Methyl gamma-D-aspartate is a dicarboxylic acid monoester obtained by condensation of the side-chain carboxy group of D-aspartic acid with methanol. It has a role as a bacterial metabolite. It is a D-aspartic acid derivative and a dicarboxylic acid monoester.

Synthesis

67-56-1

1783-96-6

21394-81-0

At 0 °C, 73.7 mL of acetyl chloride (1.4 eq.) was slowly added dropwise to 250 mL of methanol. Maintaining 0 °C, the mixture was added dropwise to a 250 mL methanol suspension containing 100 g (751 mmol) of (R)-2-aminosuccinic acid. The reaction mixture was stirred at 0 °C for 3 h before gradually warming to room temperature and continuing to stir overnight. Five identical reaction vials were set up in parallel for the same operation. The mixtures from all six reaction flasks were combined and concentrated under reduced pressure. The concentrated residue was treated with methyl tert-butyl ether (MTBE) and the resulting precipitate was filtered and dried under reduced pressure to give (R)-2-amino-4-methoxy-4-oxobutanoic acid (600 g, 90% yield) as a white solid. The product was characterized by 1H NMR (400 MHz, deuterium oxide): δ 4.33 (t, J = 5.5 Hz, 1H), 3.81 (s, 1H), 3.72 (s, 3H), 3.10 (d, J = 4.9 Hz, 2H).

References

[1] Patent: WO2017/89458, 2017, A1. Location in patent: Page/Page column 72
[2] Gazzetta Chimica Italiana, 1986, vol. 116, # 10, p. 607 - 608
[3] Patent: CN106518701, 2017, A. Location in patent: Paragraph 0021-0022

D-ASPARTIC ACID-BETA-METHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from D-ASPARTIC ACID-BETA-METHYL ESTER manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd
Product
D-Asp(Ome).HCl 21394-81-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T+
Release date
2024-03-21

21394-81-0, D-ASPARTIC ACID-BETA-METHYL ESTERRelated Search:

D-ASPARTIC ACID(OBZL)-OBZL P-TOSYLATE 4-methyl hydrogen D-aspartate hydrochloride H-D-Asp(Otbu)-(O-2-PhiPr) H-D-Asp(OEt)-OH H-D-Asp(OtBu)-OMe·HCl H-D-Asp(OEt)-OtBu.Hcl D-Aspartic Acid diethyl ester hydrochloride H-D-ASP(OBZL)-OH H-D-Asp(OtBu)-OtBu · HCl D-Aspartic acid, 4-(1,1-dimethylethyl) 1-methyl ester D-Aspartic acid 4-tert-butyl ester FMOC-D-ASP(2-PHENYLISOPROPYL ESTER)-OH D-ASPARTIC ACID-BETA-METHYL ESTER Fmoc-D-Aspartic acid beta-tert-butyl ester D-ASPARTIC ACID DIMETHYL ESTER HYDROCHLORIDE Boc-D-aspartic acid 4-benzyl ester Z-D-ASP(OTBU)-OH H2O Boc-D-aspartic acid 4-cyslohexyl ester

  • D-ASPARTIC ACID-BETA-METHYL ESTER
  • H-D-Aspartic acid-β-methyl ester
  • D-Aspartic acid-β-methyl ester
  • β-Methyl (2R)-aspartate ester
  • H-D-ASPARTIC ACID-SS-METHYL ESTER
  • D-Asp(OMe)-OH·HCl
  • D-Aspartic acid ?-methyl ester hydrochloride99%
  • D-Asp(Ome).HCl
  • (R)-2-AMino-4-Methoxy-4-oxobutanoic acid
  • H-D-Aspartic acid-
  • H-D-Aspartic acid-β-methyl ester, BR
  • (2R)-2-amino-4-methoxy-4-oxobutanoic acid
  • D-ASPARTICACID-β-METHYLESTER
  • D-ASPARTIC ACID-BETA-METHYL ESTER USP/EP/BP
  • H-D-ASPARTIC ACID-BETA-METHYL ESTER
  • D-Aspartic acid β-methyl ester hydrochloride
  • (2R)-2-azaniumyl-4-methoxy-4-oxobutanoate
  • D-Aspartic acid, 4-methyl ester (9CI, ACI)
  • Asparagine Impurity 24
  • 21394-81-0