ChemicalBook > CAS DataBase List > 1-(4,4-DIPHENYL-3-BUTENYL)-3-PIPERIDINECARBOXYLIC ACID HYDROCHLORIDE

1-(4,4-DIPHENYL-3-BUTENYL)-3-PIPERIDINECARBOXYLIC ACID HYDROCHLORIDE

Product Name
1-(4,4-DIPHENYL-3-BUTENYL)-3-PIPERIDINECARBOXYLIC ACID HYDROCHLORIDE
CAS No.
85375-15-1
Chemical Name
1-(4,4-DIPHENYL-3-BUTENYL)-3-PIPERIDINECARBOXYLIC ACID HYDROCHLORIDE
Synonyms
skf-89976a;SKF89976AHCl;SKF 89976A HYDROCHLORIDE;l-SKF89976A hydrochloride;d,l-SKF89976A hydrochloride;SKF89976A hydrochloride, 10 mM in DMSO;1-(4,4-diphenylbut-3-enyl)piperidine-3-carboxylic acid;1-(4,4-DIPHENYL-3-BUTENYL)-3-PIPERIDINECARBOXYLIC ACID HYDROCHLORIDE;1-(4,4-Diphenylbut-3-en-1-yl)piperidine-3-carboxylic acid hydrochloride;1-(4,4-Diphenyl-3-buten-1-yl)-3-piperidinecarboxylic acid hydrochloride
CBNumber
CB7194179
Molecular Formula
C22H26ClNO2
Formula Weight
371.9
MOL File
85375-15-1.mol
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1-(4,4-DIPHENYL-3-BUTENYL)-3-PIPERIDINECARBOXYLIC ACID HYDROCHLORIDE Property

storage temp. 
Inert atmosphere,2-8°C
solubility 
DMSO: 20 mg/mL, soluble
form 
solid
color 
white
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Safety

WGK Germany 
3
RTECS 
TM6241000
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S9066
Product name
SKF-89976A
Purity
>98% (HPLC), solid
Packaging
10mg
Price
$143
Updated
2022/05/15
Tocris
Product number
1081
Product name
SKF89976Ahydrochloride
Purity
≥99%(HPLC)
Packaging
10
Price
$159
Updated
2021/12/16
Tocris
Product number
1081
Product name
SKF89976Ahydrochloride
Purity
≥99%(HPLC)
Packaging
50
Price
$658
Updated
2021/12/16
TRC
Product number
S550003
Product name
SKF-89976A
Packaging
25mg
Price
$180
Updated
2021/12/16
ChemScene
Product number
CS-6040
Product name
SKF89976Ahydrochloride
Purity
99.33%
Packaging
5mg
Price
$72
Updated
2021/12/16
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1-(4,4-DIPHENYL-3-BUTENYL)-3-PIPERIDINECARBOXYLIC ACID HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

SKF-89976A is a GABA transporters (GATs) type 1 inhibitor.

Biological Activity

A potent GABA uptake inhibitor, selective for GAT-1 (IC 50 values are 0.13, 550, 944 and 7210 μ M for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively). Inhibits transport current competitively (K i = 7 μ M) and transmitter-gated current non-competitively (K i = 0.03 nM). Able to pass the blood-brain barrier after systemic administration and is active in vivo .

in vivo

SKF89976A produces a weak antiallodynic response when administered i.v. (0.3 mg/kg). The i.t. injection of SKF89976A dose-dependently ameliorates the reduction in the withdrawal threshold in PSL model mice[1].

storage

+4°C (desiccate)

1-(4,4-DIPHENYL-3-BUTENYL)-3-PIPERIDINECARBOXYLIC ACID HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(4,4-DIPHENYL-3-BUTENYL)-3-PIPERIDINECARBOXYLIC ACID HYDROCHLORIDE Suppliers

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85375-15-1, 1-(4,4-DIPHENYL-3-BUTENYL)-3-PIPERIDINECARBOXYLIC ACID HYDROCHLORIDERelated Search:

3-Methyl-1-butene 1-METHYLPIPERIDINE-3-CARBOXYLIC ACID HYDROCHLORIDE 1-(4,4-DIPHENYL-3-BUTENYL)-3-PIPERIDINECARBOXYLIC ACID HYDROCHLORIDE

  • SKF 89976A HYDROCHLORIDE
  • 1-(4,4-DIPHENYL-3-BUTENYL)-3-PIPERIDINECARBOXYLIC ACID HYDROCHLORIDE
  • SKF89976AHCl
  • skf-89976a
  • 1-(4,4-Diphenyl-3-buten-1-yl)-3-piperidinecarboxylic acid hydrochloride
  • 1-(4,4-Diphenylbut-3-en-1-yl)piperidine-3-carboxylic acid hydrochloride
  • l-SKF89976A hydrochloride
  • d,l-SKF89976A hydrochloride
  • Gamma-aminobutyric acid Receptor,γ-Aminobutyric acid Receptor,d,l-SKF89976A,GABA Receptor,SKF89976A,inhibit,SKF89976A hydrochloride,Inhibitor,SKF-89976A hydrochloride
  • SKF89976A hydrochloride, 10 mM in DMSO
  • 1-(4,4-diphenylbut-3-enyl)piperidine-3-carboxylic acid
  • 85375-15-1
  • C22H25NO2HCl
  • Ion Channels
  • Ligand-Gated Ion Channels
  • GABA and Glycine Receptor Modulators
  • Cell Biology
  • Cell Signaling and Neuroscience
  • BioChemical
  • GABA/Glycine receptor
  • GABA