Clocortolone
- Product Name
- Clocortolone
- CAS No.
- 4828-27-7
- Chemical Name
- Clocortolone
- Synonyms
- 9-Chlor;Clocortolon;CLOCORTOLONE;Clocortolona;Clocortolonum;9-Chloro-6α-fluoro-11β,21-dihydroxy-17α-Methylpregna-1,4-diene-3,20-dione;9-Chloro-6α-fluoro-11β,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione;(6α,11β,16α)-9-Chloro-6-fluoro-11,21-dihydroxy-16-Methylpregna-1,4-diene-3,20-dione;Pregna-1,4-diene-3,20-dione, 9-chloro-6-fluoro-11,21-dihydroxy-16-methyl-, (6α,11β,16α)-;Pregna-1,4-diene-3,20-dione, 9-chloro-6-fluoro-11,21-dihydroxy-16-methyl-, (6a,11b,16a)-
- CBNumber
- CB7198298
- Molecular Formula
- C22H28ClFO4
- Formula Weight
- 410.91
- MOL File
- 4828-27-7.mol
Clocortolone Property
- Melting point:
- 254° (dec)
- Boiling point:
- 566.0±50.0 °C(Predicted)
- Density
- 1.32±0.1 g/cm3(Predicted)
- storage temp.
- Refrigerator, Under Inert Atmosphere
- solubility
- Chloroform (Slightly), Dioxane (Slightly), DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 12.98±0.10(Predicted)
- color
- White to Light Yellow
N-Bromosuccinimide Price
- Product number
- C583800
- Product name
- Clocortolone
- Packaging
- 1mg
- Price
- $545
- Updated
- 2021/12/16
- Product number
- 68825
- Product name
- Clocortolone
- Packaging
- 0.5mg
- Price
- $775
- Updated
- 2021/12/16
- Product number
- SHG0000465
- Product name
- CLOCORTOLONE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $3025
- Updated
- 2021/12/16
- Product number
- 68825
- Product name
- Clocortolone
- Packaging
- 10mg
- Price
- $5000
- Updated
- 2021/12/16
- Product number
- FC20491
- Product name
- Clocortolone
- Packaging
- 10mg
- Price
- $60
- Updated
- 2021/12/16
Clocortolone Chemical Properties,Usage,Production
Originator
Clocortolone,Schering AG
Uses
Corticosteroid used in the treatment of skin inflammmation and other skin conditions arising for dermatoses.
Uses
Clocortolone can be used in the treatment of skin inflammmation and other skin conditions arising for dermatoses.
Definition
ChEBI: Clocortolone is 16alpha-Methylpregna-1,4-diene-3,20-dione bearing hydroxy substituents at the 11beta and 21 positions, fluorine at position 6 and chlorine at position 9. A medium potency corticosteroid, it is used as its 21-O-pivalate or caproate ester for the relief of inflammatory and pruritic (itching) skin disorders. It has a role as an anti-inflammatory drug and an antipruritic drug. It is a glucocorticoid, an 11beta-hydroxy steroid, a 21-hydroxy steroid, a 20-oxo steroid, a fluorinated steroid, a 3-oxo-Delta(1),Delta(4)-steroid, a chlorinated steroid and a primary alpha-hydroxy ketone.
Manufacturing Process
6α-Fluoro-16α-methyl-21-hydroxy-1,4,9(11)-pregnatriene-3,20-dione is suspended in nitroethane at heating. To this suspension 1 N perchloric acid is added and then t-butyl hypochlorite is added dropwise. The reaction mixture is agitated at heating, then cooled to room temperature, mixed with methanol, stirred and then poured with water containing ice. The mixture is then stirred, thus precipitated product is filtered, washed neutral with water, dried; The crude product is treated with hot methanol, and recrystallized from ethanol, thus 9α-chloro-6α-fluoro-11β,21-dihydroxy-16α-methyl-1,4- pregnadiene-3,20-dione was obtained.
Therapeutic Function
Glucocorticoid
Clocortolone Preparation Products And Raw materials
Raw materials
Preparation Products
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