Clocortolone

Product Name: Clocortolone
CAS No.: 4828-27-7
Chemical Name: Clocortolone
Synonyms: 9-Chlor;Clocortolon;CLOCORTOLONE;Clocortolona;Clocortolonum;9-Chloro-6α-fluoro-11β,21-dihydroxy-17α-Methylpregna-1,4-diene-3,20-dione;9-Chloro-6α-fluoro-11β,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione;(6α,11β,16α)-9-Chloro-6-fluoro-11,21-dihydroxy-16-Methylpregna-1,4-diene-3,20-dione;Pregna-1,4-diene-3,20-dione, 9-chloro-6-fluoro-11,21-dihydroxy-16-methyl-, (6α,11β,16α)-;Pregna-1,4-diene-3,20-dione, 9-chloro-6-fluoro-11,21-dihydroxy-16-methyl-, (6a,11b,16a)-
CBNumber: CB7198298
Molecular Formula: C22H28ClFO4
Formula Weight: 410.91
MOL File: 4828-27-7.mol

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Clocortolone Property

Melting point:: 254° (dec)
Boiling point:: 566.0±50.0 °C(Predicted)
Density: 1.32±0.1 g/cm3(Predicted)
storage temp.: Refrigerator, Under Inert Atmosphere
solubility: Chloroform (Slightly), Dioxane (Slightly), DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 12.98±0.10(Predicted)
color: White to Light Yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: C583800
Product name: Clocortolone
Packaging: 1mg
Price: $545
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 68825
Product name: Clocortolone
Packaging: 0.5mg
Price: $775
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: SHG0000465
Product name: CLOCORTOLONE
Purity: 95.00%
Packaging: 5MG
Price: $3025
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 68825
Product name: Clocortolone
Packaging: 10mg
Price: $5000
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC20491
Product name: Clocortolone
Packaging: 10mg
Price: $60
Updated: 2021/12/16

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Clocortolone Chemical Properties,Usage,Production

Originator

Clocortolone,Schering AG

Uses

Corticosteroid used in the treatment of skin inflammmation and other skin conditions arising for dermatoses.

Uses

Clocortolone can be used in the treatment of skin inflammmation and other skin conditions arising for dermatoses.

Definition

ChEBI: Clocortolone is 16alpha-Methylpregna-1,4-diene-3,20-dione bearing hydroxy substituents at the 11beta and 21 positions, fluorine at position 6 and chlorine at position 9. A medium potency corticosteroid, it is used as its 21-O-pivalate or caproate ester for the relief of inflammatory and pruritic (itching) skin disorders. It has a role as an anti-inflammatory drug and an antipruritic drug. It is a glucocorticoid, an 11beta-hydroxy steroid, a 21-hydroxy steroid, a 20-oxo steroid, a fluorinated steroid, a 3-oxo-Delta(1),Delta(4)-steroid, a chlorinated steroid and a primary alpha-hydroxy ketone.

Manufacturing Process

6α-Fluoro-16α-methyl-21-hydroxy-1,4,9(11)-pregnatriene-3,20-dione is suspended in nitroethane at heating. To this suspension 1 N perchloric acid is added and then t-butyl hypochlorite is added dropwise. The reaction mixture is agitated at heating, then cooled to room temperature, mixed with methanol, stirred and then poured with water containing ice. The mixture is then stirred, thus precipitated product is filtered, washed neutral with water, dried; The crude product is treated with hot methanol, and recrystallized from ethanol, thus 9α-chloro-6α-fluoro-11β,21-dihydroxy-16α-methyl-1,4- pregnadiene-3,20-dione was obtained.

Therapeutic Function

Glucocorticoid

Clocortolone Preparation Products And Raw materials

Raw materials

Preparation Products

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4828-27-7, ClocortoloneRelated Search:

Clindamycin hydrochloride CHLOROPHOSPHONAZO III CARBOPHENOTHION-METHYL Fluorine Difluorochloromethane 2-CHLOROCYCLOHEXANOL CLOCORTOLONE HEXANOATE Clocortolone acetate fluocortolone/mometasone/clocortolone trans-2-Chlorocyclohexanol CLOCORTOLONE PIVALATE Clocortolone

CLOCORTOLONE

(6s,9r,16r)-9-chloro-6-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,11,12,14,15,16,17-octahydro-6h-cyclopenta[a]phenanthren-3-one

9-alpha-chloro-6-alpha-fluoro-11-beta,21-dihydroxy-16-alpha-methylpregna-1,4-diene-3,20-dione

(6α,11β,16α)-9-Chloro-6-fluoro-11,21-dihydroxy-16-Methylpregna-1,4-diene-3,20-dione

9-Chlor

9-Chloro-6α-fluoro-11β,21-dihydroxy-17α-Methylpregna-1,4-diene-3,20-dione

Clocortolon

(6S,8S,9R,10S,11S,13S,14S,16R,17S)-9-Chloro-6-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,11,12,14,15,16,17-octahydro-6H-cyclopenta[a]phenanthren-3-one

Pregna-1,4-diene-3,20-dione, 9-chloro-6-fluoro-11,21-dihydroxy-16-methyl-, (6a,11b,16a)-

9-Chloro-6α-fluoro-11β,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione

Pregna-1,4-diene-3,20-dione, 9-chloro-6-fluoro-11,21-dihydroxy-16-methyl-, (6α,11β,16α)-

Clocortolona

Clocortolonum

Clocortolone (25 mg) (9-Chloro-6alpha-fluoro-11beta,21-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione)

4828-27-7

C22H28CIFO4

Intermediates & Fine Chemicals

Pharmaceuticals

Steroids