ChemicalBook > CAS DataBase List > 4-TRIFLUOROMETHYL-BENZAMIDINE HCL

4-TRIFLUOROMETHYL-BENZAMIDINE HCL

Uses

Product Name: 4-TRIFLUOROMETHYL-BENZAMIDINE HCL
CAS No.: 38980-96-0
Chemical Name: 4-TRIFLUOROMETHYL-BENZAMIDINE HCL
Synonyms: 4-TRIFLUOROMETHYL-BENZAMIDINE HCL;4-TrifluoroMethyl-benzanidibe HCL;4-Trifluoromethylbenzamidinehydrochloridel;4-TRIFLUOROMETHYL-BENZAMIDINE HYDROCHLORIDE;4-TRIFLUOROMETHYL-BENZAMIDINE HCL ISO 9001：2015 REACH;4-(Trifluoromethyl)benzenecarboximidamide hydrochloride;4-(Trifluoromethyl)benzene-1-carboximidamide hydrochloride;4-(TrifluoroMethyl)benzenecarboxiMidaMide hydrochloride (1:1)
CBNumber: CB7199927
Molecular Formula: C8H8ClF3N2
Formula Weight: 224.61
MOL File: 38980-96-0.mol

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4-TRIFLUOROMETHYL-BENZAMIDINE HCL Property

Melting point:: 158-161℃
storage temp.: Inert atmosphere,Room Temperature
form: powder to crystal
color: White to Almost white

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38-43
Safety Statements: 26-37/39-36/37
HS Code: 2925290090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CVT00069
Product name: 4-(Trifluoromethyl)benzamidine
Packaging: 1g
Price: $550
Updated: 2025/07/31

TCI Chemical

Product number: T3115
Product name: 4-(Trifluoromethyl)benzamidine Hydrochloride
Purity: >98.0%(HPLC)
Packaging: 200mg
Price: $114
Updated: 2025/07/31

TCI Chemical

Product number: T3115
Product name: 4-(Trifluoromethyl)benzamidine Hydrochloride
Purity: >98.0%(HPLC)
Packaging: 1g
Price: $329
Updated: 2025/07/31

TRC

Product number: T791008
Product name: 4-(Trifluoromethyl)benzamidine Hydrochloride
Packaging: 100mg
Price: $60
Updated: 2021/12/16

TRC

Product number: T791008
Product name: 4-(Trifluoromethyl)benzamidine Hydrochloride
Packaging: 50mg
Price: $45
Updated: 2021/12/16

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4-TRIFLUOROMETHYL-BENZAMIDINE HCL Chemical Properties,Usage,Production

Uses

4-Trifluoromethylbenzamide hydrochloride is used as a pharmaceutical synthesis intermediate.

Synthesis

455-18-5

38980-96-0

4-(Trifluoromethyl)benzonitrile (15g, Avocado 14514) was used as raw material, which was dissolved in anhydrous methanol (90 ml) and sodium methanolate (0.50 g) was added. The reaction mixture was stirred at room temperature for 4 days. Subsequently, ammonium chloride (4.7 g) was added to the reaction system and stirring was continued for 24 hours. Upon completion of the reaction, the solvent was removed by rotary evaporator and the white solid residue obtained was ground with ether, filtered and dried to afford the target product 4-(trifluoromethyl)benzamidine hydrochloride as a white solid (14.2 g, 72% yield). Mass spectrometry analysis showed a molecular ion peak of 188 [M]+.

References

[1] Patent: US2003/69276, 2003, A1
[2] Journal of the American Chemical Society, 1985, vol. 107, # 9, p. 2743 - 2748
[3] Journal of Medicinal Chemistry, 1990, vol. 33, # 4, p. 1230 - 1241
[4] Patent: US6121202, 2000, A
[5] Patent: US2012/165343, 2012, A1. Location in patent: Page/Page column 55

4-TRIFLUOROMETHYL-BENZAMIDINE HCL Preparation Products And Raw materials

Raw materials

Preparation Products

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4-TRIFLUOROMETHYL-BENZAMIDINE HCL

4-TRIFLUOROMETHYL-BENZAMIDINE HYDROCHLORIDE

4-Trifluoromethylbenzamidinehydrochloridel

4-(Trifluoromethyl)benzenecarboximidamide hydrochloride

4-TrifluoroMethyl-benzanidibe HCL

4-(TrifluoroMethyl)benzenecarboxiMidaMide hydrochloride (1:1)

4-(Trifluoromethyl)benzene-1-carboximidamide hydrochloride

4-TRIFLUOROMETHYL-BENZAMIDINE HCL ISO 9001：2015 REACH

38980-96-0

C8H7F3N2HCl

pharmacetical