NORCODEINE Property

Melting point:

1850C

Boiling point:

467.7±45.0 °C(Predicted)

Density 

1.37±0.1 g/cm3(Predicted)

Flash point:

9℃

storage temp. 

-20°C

solubility 

DMF: 20 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 10 mg/ml

form 

A crystalline solid

pka

pKa 9.23± 0.01(H2O,t =25±0.1,I=0.15(KCl)Ar)(Approximate)

Safety

Hazard Codes 

F,T

Risk Statements 

11-23/24/25-39/23/24/25

Safety Statements 

7-16-36/37-45

RIDADR 

UN1230 - class 3 - PG 2 - Methanol, solution

WGK Germany 

1

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H370Causes damage to organs

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P311Call a POISON CENTER or doctor/physician.

NORCODEINE Chemical Properties,Usage,Production

Chemical Properties

Crystalline Solid

Uses

(-)-N-Norcodeine is a metabolite of Codeine. Morphine derivative.

Definition

ChEBI: A morphinane-like compound that is the N-demethylated derivative of codeine.

Purification Methods

It crystallises from acetone or ethyl acetate. [Speyer & Walther Chem Ber 63 822 1930.] The hydrochloride has m 309o(dec) when crystallised from H2O. [Beilstein 18 III/IV 8091.]