ChemicalBook > CAS DataBase List > Cevimeline Hydrochloride Salt

Cevimeline Hydrochloride Salt

Product Name
Cevimeline Hydrochloride Salt
CAS No.
107220-28-0
Chemical Name
Cevimeline Hydrochloride Salt
Synonyms
SNK 508;Fks 508;Snd 5008;Saligren;CeviMelin;rac-Cevimeline HCl;AF-102B hydrochloride;SNI-2011 hydrochloride;Cevimelin Hydrochloride;CEVIMELINE, HYDROCHLORIDE SALT
CBNumber
CB72130375
Molecular Formula
C10H18ClNOS
Formula Weight
235.77402
MOL File
107220-28-0.mol
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Cevimeline Hydrochloride Salt Property

Melting point:
195-197?C
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
Water:50.0(Max Conc. mg/mL);212.07(Max Conc. mM)
form 
A crystalline solid
color 
White to off-white
Stability:
Hygroscopic
InChI
InChI=1S/C10H17NOS.ClH/c1-8-12-10(7-13-8)6-11-4-2-9(10)3-5-11;/h8-9H,2-7H2,1H3;1H
InChIKey
SURWTGAXEIEOGY-UHFFFAOYSA-N
SMILES
C1CC2C3(CSC(C)O3)CN1CC2.Cl
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Safety

Toxicity
mouse,LD50,intravenous,33mg/kg (33mg/kg),United States Patent Document. Vol. #4855290,
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
17802
Product name
Cevimeline (hydrochloride)
Purity
≥98%
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
17802
Product name
Cevimeline (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$98
Updated
2024/03/01
Cayman Chemical
Product number
17802
Product name
Cevimeline (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$161
Updated
2024/03/01
TRC
Product number
C283500
Product name
rac,cis-CevimelineHydrochlorideSalt
Packaging
10mg
Price
$145
Updated
2021/12/16
TRC
Product number
C283500
Product name
rac,cis-CevimelineHydrochlorideSalt
Packaging
25mg
Price
$335
Updated
2021/12/16
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Cevimeline Hydrochloride Salt Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

A novel muscarinic M1 and M3 receptor agonist. Sialagogue.

Biological Activity

Selective M 1 receptor agonist. Induces atropine-sensitive contractions of isolated guinea pig ilea and trachea preparations (EC 50 values are 3.5 and 3 μ M respectively). Reverses AF64A-induced cognitive impairments in vivo .

in vivo

Cevimeline (0.008-0.016 mg/kg; intraperitoneal injection; male Wistar rats) treatment shows slowly increasing and lasting salivation, and increased blood flow increment in the parotid gland and pressor response. Cevimeline inhibits angiotensin II-induced water intake and neuronal activity in the subfornical organ at 0.016 mg/kg[1].

Animal Model:Male Wistar rats (8-week-old) injected with angiotensin-II[1]
Dosage:0.008 mg/kg, 0.016 mg/kg
Administration:Intraperitoneal injection
Result:Showed slowly increasing and lasting salivation, and increased blood flow increment in the parotid gland and pressor response.

IC 50

mAChR1; mAChR3

storage

-20°C

Cevimeline Hydrochloride Salt Preparation Products And Raw materials

Raw materials

Preparation Products

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Cevimeline Hydrochloride Salt Suppliers

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View Lastest Price from Cevimeline Hydrochloride Salt manufacturers

HangZhou RunYan Pharma Technology Co.,LTD.
Product
Cevimeline HCl; Cevimeline;AF102B 107220-28-0
Price
US $0.00/kg
Min. Order
1kg
Purity
99.0%min. HPLC
Supply Ability
1000kg
Release date
2024-09-10

107220-28-0, Cevimeline Hydrochloride SaltRelated Search:

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