METHYL-PYRROLIDIN-3-YL-CARBAMIC ACID TERT-BUTYL ESTER

Product Name: METHYL-PYRROLIDIN-3-YL-CARBAMIC ACID TERT-BUTYL ESTER
CAS No.: 392338-15-7
Chemical Name: METHYL-PYRROLIDIN-3-YL-CARBAMIC ACID TERT-BUTYL ESTER
Synonyms: (R)-3-Boc-methylamino-pyrrolidine;(R)-3-(N-Boc-MethylaMino)pyrrolidine;(R)-3-(N-Boc-N-methylamino)pyrrolidine;tert-butyl (R)-methyl(pyrrolidin-3-yl)carbamate;tert-Butyl methyl[(3R)-pyrrolidin-3-yl]carbamate;(3R)-3-(Methylamino)pyrrolidine, 3-BOC protected;tert-Butyl (R)-N-methyl-N-(pyrrolidin-3-yl)carbamate;tert-butyl N-Methyl-N-[(3R)-pyrrolidin-3-yl]carbaMate;METHYL-PYRROLIDIN-3-YL-CARBAMIC ACID TERT-BUTYL ESTER;(R)-3-[N-(tert-Butoxycarbonyl)-N-methylamino]pyrrolidine
CBNumber: CB72130951
Molecular Formula: C10H20N2O2
Formula Weight: 200.28
MOL File: 392338-15-7.mol

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METHYL-PYRROLIDIN-3-YL-CARBAMIC ACID TERT-BUTYL ESTER Property

Boiling point:: 268℃
Density: 1.03
Flash point:: 116℃
storage temp.: 2-8°C(protect from light)
pka: 9.85±0.10(Predicted)
form: liquid
color: Pale yellow
InChI: InChI=1S/C10H20N2O2/c1-10(2,3)14-9(13)12(4)8-5-6-11-7-8/h8,11H,5-7H2,1-4H3/t8-/m1/s1
InChIKey: XYKYUXYNQDXZTD-MRVPVSSYSA-N
SMILES: C(OC(C)(C)C)(=O)N(C)[C@@H]1CCNC1

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B810370
Product name: (R)-tert-ButylMethyl(pyrrolidin-3-yl)carbamate
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB32879
Product name: (R)-3-Boc-methylaminopyrrolidine
Packaging: 50mg
Price: $58
Updated: 2021/12/16

Apolloscientific

Product number: OR308136
Product name: (3R)-3-(Methylamino)pyrrolidine,3-BOCprotected
Packaging: 1g
Price: $63
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB32879
Product name: (R)-3-Boc-methylaminopyrrolidine
Packaging: 100mg
Price: $105
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB32879
Product name: (R)-3-Boc-methylaminopyrrolidine
Packaging: 250mg
Price: $210
Updated: 2021/12/16

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METHYL-PYRROLIDIN-3-YL-CARBAMIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production

Synthesis

638217-49-9

392338-15-7

General procedure for the synthesis of (R)-3-(N-BOC-N-methylamino)pyrrolidine from the compound (CAS: 638217-49-9): preparation of tert-butyl [(3R)-pyrrolidin-3-yl]carbamate; dissolution of carbamate of compound 46 (15.58 g, 46.6 mmol) in ethanol (150 mL) under 5% Pd/C (1 g) ) catalyzed hydrogenation at 50 psi hydrogen pressure and room temperature for 18 hours. Subsequently, Pd/C (500 mg) was added additionally and the hydrogenation was continued under the same conditions for 26 hours. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under vacuum. Purification by column chromatography (eluent: DCM:MeOH:0.880 ammonia, volumetric ratio tapered from 100:0:0 to 90:10:1) afforded (R)-3-(N-BOC-N-methylamino)pyrrolidine as a light yellow oil (5.85 g, 62% yield).1H NMR (400 MHz, CDCl3) δ: 4.56 (1H, m) , 3.06 (2H, m), 2.87 (1H, m), 2.79 (1H, m), 2.78 (3H, s), 2.54 (1H, s), 1.95 (1H, m), 1.73 (1H, m), 1.43 (9H, s) ppm. m/z MS (ESI): 201 [M + H]+.

References

[1] Patent: US2007/185075, 2007, A1. Location in patent: Page/Page column 23-24
[2] Patent: WO2010/75270, 2010, A1. Location in patent: Page/Page column 179

METHYL-PYRROLIDIN-3-YL-CARBAMIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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METHYL-PYRROLIDIN-3-YL-CARBAMIC ACID TERT-BUTYL ESTER Suppliers

China 95 India 1 United Kingdom 2 United States 13 Global 111

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392338-15-7, METHYL-PYRROLIDIN-3-YL-CARBAMIC ACID TERT-BUTYL ESTERRelated Search:

(R)-3-N-Boc-3-(methylamino)piperidine Carbamic acid, [(2R)-2-pyrrolidinylmethyl]-, 1,1-dimethylethyl ester (9CI) (S)-3-(Boc-amino)pyrrolidine METHYL-PYRROLIDIN-3-YL-CARBAMIC ACID TERT-BUTYL ESTER 3-(N-TERT-BUTOXYCARBONYL-N-METHYLAMINO)PYRROLIDINE 2,5-DIAZA-BICYCLO[2.2.1]HEPTANE-2-CARBOXYLIC ACID TERT-BUTYL ESTER N-BOC-2,5-DIAZA-BICYCLO[2.2.1]HEPTANE DITRIFLUOROACETATE

METHYL-PYRROLIDIN-3-YL-CARBAMIC ACID TERT-BUTYL ESTER

(3R)-3-(Methylamino)pyrrolidine, 3-BOC protected

tert-Butyl (R)-N-methyl-N-(pyrrolidin-3-yl)carbamate

tert-butyl N-Methyl-N-[(3R)-pyrrolidin-3-yl]carbaMate

(R)-3-[N-(tert-Butoxycarbonyl)-N-methylamino]pyrrolidine

(R)-N-(Methyl)-N-(pyrrolidin-3-yl)carbamic acid tert-butyl ester

tert-Butyl methyl[(3R)-pyrrolidin-3-yl]carbamate

(R)-3-(N-Boc-MethylaMino)pyrrolidine

Carbamic acid, N-methyl-N-(3R)-3-pyrrolidinyl-, 1,1-dimethylethyl ester

tert-butyl (R)-methyl(pyrrolidin-3-yl)carbamate

(R)-3-Boc-methylamino-pyrrolidine

(R)-3-(N-Boc-N-methylamino)pyrrolidine

392338-15-7