ChemicalBook > CAS DataBase List > METHYL-PYRROLIDIN-3-YL-CARBAMIC ACID TERT-BUTYL ESTER

METHYL-PYRROLIDIN-3-YL-CARBAMIC ACID TERT-BUTYL ESTER

Product Name
METHYL-PYRROLIDIN-3-YL-CARBAMIC ACID TERT-BUTYL ESTER
CAS No.
392338-15-7
Chemical Name
METHYL-PYRROLIDIN-3-YL-CARBAMIC ACID TERT-BUTYL ESTER
Synonyms
(R)-3-Boc-methylamino-pyrrolidine;(R)-3-(N-Boc-MethylaMino)pyrrolidine;(R)-3-(N-Boc-N-methylamino)pyrrolidine;tert-butyl (R)-methyl(pyrrolidin-3-yl)carbamate;tert-Butyl methyl[(3R)-pyrrolidin-3-yl]carbamate;(3R)-3-(Methylamino)pyrrolidine, 3-BOC protected;tert-Butyl (R)-N-methyl-N-(pyrrolidin-3-yl)carbamate;tert-butyl N-Methyl-N-[(3R)-pyrrolidin-3-yl]carbaMate;METHYL-PYRROLIDIN-3-YL-CARBAMIC ACID TERT-BUTYL ESTER;(R)-3-[N-(tert-Butoxycarbonyl)-N-methylamino]pyrrolidine
CBNumber
CB72130951
Molecular Formula
C10H20N2O2
Formula Weight
200.28
MOL File
392338-15-7.mol
More
Less

METHYL-PYRROLIDIN-3-YL-CARBAMIC ACID TERT-BUTYL ESTER Property

Boiling point:
268℃
Density 
1.03
Flash point:
116℃
storage temp. 
2-8°C(protect from light)
pka
9.85±0.10(Predicted)
form 
liquid
color 
Pale yellow
InChI
InChI=1S/C10H20N2O2/c1-10(2,3)14-9(13)12(4)8-5-6-11-7-8/h8,11H,5-7H2,1-4H3/t8-/m1/s1
InChIKey
XYKYUXYNQDXZTD-MRVPVSSYSA-N
SMILES
C(OC(C)(C)C)(=O)N(C)[C@@H]1CCNC1
More
Less

Safety

HS Code 
2933998090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

TRC
Product number
B810370
Product name
(R)-tert-ButylMethyl(pyrrolidin-3-yl)carbamate
Packaging
50mg
Price
$45
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB32879
Product name
(R)-3-Boc-methylaminopyrrolidine
Packaging
50mg
Price
$58
Updated
2021/12/16
Apolloscientific
Product number
OR308136
Product name
(3R)-3-(Methylamino)pyrrolidine,3-BOCprotected
Packaging
1g
Price
$63
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB32879
Product name
(R)-3-Boc-methylaminopyrrolidine
Packaging
100mg
Price
$105
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB32879
Product name
(R)-3-Boc-methylaminopyrrolidine
Packaging
250mg
Price
$210
Updated
2021/12/16
More
Less

METHYL-PYRROLIDIN-3-YL-CARBAMIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production

Synthesis

638217-49-9

392338-15-7

General procedure for the synthesis of (R)-3-(N-BOC-N-methylamino)pyrrolidine from the compound (CAS: 638217-49-9): preparation of tert-butyl [(3R)-pyrrolidin-3-yl]carbamate; dissolution of carbamate of compound 46 (15.58 g, 46.6 mmol) in ethanol (150 mL) under 5% Pd/C (1 g) ) catalyzed hydrogenation at 50 psi hydrogen pressure and room temperature for 18 hours. Subsequently, Pd/C (500 mg) was added additionally and the hydrogenation was continued under the same conditions for 26 hours. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under vacuum. Purification by column chromatography (eluent: DCM:MeOH:0.880 ammonia, volumetric ratio tapered from 100:0:0 to 90:10:1) afforded (R)-3-(N-BOC-N-methylamino)pyrrolidine as a light yellow oil (5.85 g, 62% yield).1H NMR (400 MHz, CDCl3) δ: 4.56 (1H, m) , 3.06 (2H, m), 2.87 (1H, m), 2.79 (1H, m), 2.78 (3H, s), 2.54 (1H, s), 1.95 (1H, m), 1.73 (1H, m), 1.43 (9H, s) ppm. m/z MS (ESI): 201 [M + H]+.

References

[1] Patent: US2007/185075, 2007, A1. Location in patent: Page/Page column 23-24
[2] Patent: WO2010/75270, 2010, A1. Location in patent: Page/Page column 179

METHYL-PYRROLIDIN-3-YL-CARBAMIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

METHYL-PYRROLIDIN-3-YL-CARBAMIC ACID TERT-BUTYL ESTER Suppliers

China 95 India 1 United Kingdom 2 United States 13 Global 111
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
Advantage
66
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11035
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
Amber MolTech LLC
Tel
086-010-62176588
Fax
086-010-62117849
Email
amber@jyamber.com
Country
China
ProdList
10151
Advantage
56
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9865
Advantage
52
SynAsst Chemical.
Tel
021-60343070
Fax
021-35122006
Country
China
ProdList
12740
Advantage
55
Shanghai Yolne Chemical Co., Ltd.
Tel
021-62960152
Fax
021-52212593
Email
934678158@qq.com
Country
China
ProdList
9899
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
Porse Fine Chemical Co.,LTD
Tel
20-66003216 18666003216
Fax
+86-20-28069063
Email
info@porsefinechemical.com
Country
China
ProdList
1941
Advantage
62
Chengdu Firster Pharmaceutical Co., Ltd.
Tel
028-87078428 028-87074958
Fax
8772-8116
Email
chengzhenyong@cdfirster.com
Country
China
ProdList
2598
Advantage
60
Shanghai YuLue Chemical Co., Ltd.
Tel
021-60345187 13671753212
Fax
021-34702061
Email
lzz841106@aliyun.com
Country
China
ProdList
10263
Advantage
55
ShangHai AmK Pharmaceutical Technology Co., Ltd.
Tel
微信 17321281695 18019252918
Fax
17321281695
Email
sale@amkchem.com
Country
China
ProdList
15136
Advantage
55
Cool Pharm, Ltd
Tel
021-60455363 18019463053
Fax
50966098
Email
sales@coolpharm.com
Country
China
ProdList
12346
Advantage
58
Lanzhou HuaHao Pharmaceutical Co., Ltd.
Tel
18189674620
Email
761137152@qq.com
Country
China
ProdList
489
Advantage
55
Nanjing ERan Biological Pharmaceutical Co., Ltd.
Tel
13770809694
Fax
+86 25 56203983
Email
googlexu_0114@sina.com
Country
China
ProdList
990
Advantage
58
NovoChemy Ltd.
Tel
86-(0)21-31261262 373522135
Fax
86-(0)21-33250524
Email
sales@novochemy.com
Country
China
ProdList
6498
Advantage
58
SPIRO PHARMA
Tel
Fax
-
Email
eric_feng1954@126.com
Country
China
ProdList
9248
Advantage
55
Shanghai WeiNie Chemical Technology Co., Ltd.
Tel
15902145085
Fax
-
Email
657990292@qq.com
Country
China
ProdList
668
Advantage
50
TaiChem Taizhou Limited
Tel
052386810091
Email
zcwy9518@yeah.net
Country
China
ProdList
3912
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Shanghai Kangman Biological Technology Co., Ltd.
Tel
18800375331
Fax
021-50908862
Email
kangmansales@163.com
Country
China
ProdList
7570
Advantage
55
Dezhou LonWel Pharmaceutical Technology Co., Ltd.
Tel
13761310616
Fax
QQ: 39324283
Email
39324283@qq.com
Country
China
ProdList
1628
Advantage
58
Chengdu Aminotp Pharmaceutical Technology Co.,Ltd.
Tel
028-85755578 18140172005
Fax
028-85755578
Email
sales@aminotp.com
Country
China
ProdList
298
Advantage
58
Amatek Scientific Co. Ltd.
Tel
0512-56316828
Fax
0512-56316826
Email
info@amateksci.com
Country
China
ProdList
28785
Advantage
58
Nanijing m&m biotechnology Co. ,Ltd.
Tel
025-87782433 18021532344
Fax
025-87782433
Email
1345332203@qq.com
Country
China
ProdList
4135
Advantage
58
Hangzhou Molcore Biopharmatech Co.,Ltd
Tel
400-711-5280 86-571-81025280
Fax
86-571-85806285
Email
sales@molcore.com
Country
China
ProdList
9967
Advantage
58
Jiaxing Deyi Chemical Co., Ltd.
Tel
86-0573-85866609 13325730825
Fax
0573-85866609
Email
945717149@qq.com
Country
China
ProdList
8595
Advantage
58
Shanghai Yongzhi chemical-Technology Co., Ltd.
Tel
021-60944093 18516153908 13917602471
Fax
021-60944093
Email
mianyanghaodao@aliyun.com
Country
China
ProdList
411
Advantage
58
Shanghai Zhen Li Biological Technology Co., Ltd
Tel
021-16621358918; 18516310516
Fax
13045646768
Email
zhenlipharma888@163.com
Country
China
ProdList
19035
Advantage
58
Capot Chemical Co.,Ltd.
Tel
+86-（0）57185586718; +8613336195806
Fax
+86-571-85864795
Email
sales@capot.com
Country
China
ProdList
29735
Advantage
60
Aikon International Limited
Tel
025-58859352 18068836627
Fax
(5)02557626880
Email
dt3@aikonchem.com
Country
China
ProdList
15493
Advantage
58
SHANGHAI FDC-CHEMICAL CO.,LTD
Tel
021-61469567 13482353728
Fax
021-61161605
Email
sales@fdc-chemical.com
Country
China
ProdList
9721
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 400821072
Fax
021-58955996
Email
malulu@leyan.com
Country
China
ProdList
25000
Advantage
58
Zhaoqing Wanwei New Material Technology Co., Ltd.
Tel
0755-1328880-4488 13068786899
Fax
13068786899
Email
13288804488@163.com
Country
China
ProdList
625
Advantage
58
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
4009004166/18616739031 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52687
Advantage
58
Shanghai Vigor Biotechnology Co., Ltd.
Tel
021-18017654 18017654809
Fax
2271705492
Email
sales@vigorchem.cn
Country
China
ProdList
958
Advantage
58
Shanghai Moss Medicine Technology Co., Ltd.
Tel
+86-188369842 +86-15618151133
Fax
QQ188369842
Email
188369842@qq.com
Country
China
ProdList
1959
Advantage
58
Nanjing Asfam Pharmaceutical Technology Co., Ltd.
Tel
025-58867862 18751812725
Fax
02558867862
Email
sales@ace-pharm.com
Country
China
ProdList
1985
Advantage
58
Henan Alpha Chemical Co., Ltd.
Tel
0371-55055611 18137792234
Fax
QQ：3002694073
Email
3002694073@qq.com
Country
China
ProdList
9987
Advantage
58
Hefei TNJ Chemical Industry Co.,Ltd.
Tel
+86-0551-65418684 +8618949823763
Fax
0086-551-65418684
Email
sales@tnjchem.com
Country
China
ProdList
25356
Advantage
58
Nextpeptide Inc
Tel
+86-0571-81612335 +8613336028439
Email
sales@nextpeptide.com
Country
China
ProdList
19908
Advantage
58
Hangzhou Huarong Pharm Co., Ltd.
Tel
571-86758373 +8613588754946
Fax
0086-571-81131109
Email
sales@huarongpharm.com
Country
CHINA
ProdList
3148
Advantage
58
Hefei Hirisun Pharmatech Co., Ltd
Tel
+8615056975894
Fax
86-0551-62678551
Email
shawn@hirisunpharm.com
Country
CHINA
ProdList
9911
Advantage
58
Blocksynth Pharmaceutical Technology Co.,Ltd
Tel
0086-19817745290; +8619817745290
Email
bd@blocksynth.com
Country
China
ProdList
5661
Advantage
58
SIMAGCHEM CORP
Tel
+86-5922680277 +86-13806087780
Email
sale@simagchem.com
Country
China
ProdList
17346
Advantage
58
Zhejiang Lianshuo Biotechnology Co., Ltd.
Tel
18616526224
Email
lianshuo@vip.126.com
Country
China
ProdList
9607
Advantage
58
Baimei Jihua (Henan) Pharmaceutical Technology Co., Ltd
Tel
037188900765 18037465274
Fax
QQ3430974218
Email
enyawanglei@sina.cn
Country
China
ProdList
13966
Advantage
58
Shanghai Yanze Chemical Co., Ltd.
Tel
021-021-13773155751 19975051755
Email
260924549@qq.com
Country
China
ProdList
10524
Advantage
58
Chongqing Chemdad Co., Ltd
Tel
+86-023-6139-8061 +86-86-13650506873
Email
sales@chemdad.com
Country
China
ProdList
39927
Advantage
58

392338-15-7, METHYL-PYRROLIDIN-3-YL-CARBAMIC ACID TERT-BUTYL ESTERRelated Search:

(R)-3-N-Boc-3-(methylamino)piperidine Carbamic acid, [(2R)-2-pyrrolidinylmethyl]-, 1,1-dimethylethyl ester (9CI) (S)-3-(Boc-amino)pyrrolidine METHYL-PYRROLIDIN-3-YL-CARBAMIC ACID TERT-BUTYL ESTER 3-(N-TERT-BUTOXYCARBONYL-N-METHYLAMINO)PYRROLIDINE 2,5-DIAZA-BICYCLO[2.2.1]HEPTANE-2-CARBOXYLIC ACID TERT-BUTYL ESTER N-BOC-2,5-DIAZA-BICYCLO[2.2.1]HEPTANE DITRIFLUOROACETATE

  • METHYL-PYRROLIDIN-3-YL-CARBAMIC ACID TERT-BUTYL ESTER
  • (3R)-3-(Methylamino)pyrrolidine, 3-BOC protected
  • tert-Butyl (R)-N-methyl-N-(pyrrolidin-3-yl)carbamate
  • tert-butyl N-Methyl-N-[(3R)-pyrrolidin-3-yl]carbaMate
  • (R)-3-[N-(tert-Butoxycarbonyl)-N-methylamino]pyrrolidine
  • (R)-N-(Methyl)-N-(pyrrolidin-3-yl)carbamic acid tert-butyl ester
  • tert-Butyl methyl[(3R)-pyrrolidin-3-yl]carbamate
  • (R)-3-(N-Boc-MethylaMino)pyrrolidine
  • Carbamic acid, N-methyl-N-(3R)-3-pyrrolidinyl-, 1,1-dimethylethyl ester
  • tert-butyl (R)-methyl(pyrrolidin-3-yl)carbamate
  • (R)-3-Boc-methylamino-pyrrolidine
  • (R)-3-(N-Boc-N-methylamino)pyrrolidine
  • 392338-15-7