DIETHYL 4-CHLOROPHENYL MALONATE
- Product Name
- DIETHYL 4-CHLOROPHENYL MALONATE
- CAS No.
- 19677-37-3
- Chemical Name
- DIETHYL 4-CHLOROPHENYL MALONATE
- Synonyms
- RARECHEM AL BI 0611;2-(4-chlorophenyl)Malonic acid;DIETHYL 4-CHLOROPHENYL MALONATE;Diethyl (p-chlorophenyl)malonate;Diethyl 2-(4-chlorophenyl)Malonate;diethyl 2-(4-chlorophenyl)propanedioate;4-chlorophenyl 1-ethyl 2-ethylpropanedioate;2-(4-Chlorophenyl)-malonic acid diethylester;PROPANEDIOIC ACID, 2-(4-CHLOROPHENYL)-, 1,3-DIETHYL ESTER
- CBNumber
- CB7217034
- Molecular Formula
- C13H15ClO4
- Formula Weight
- 270.71
- MOL File
- 19677-37-3.mol
DIETHYL 4-CHLOROPHENYL MALONATE Property
- Boiling point:
- 178-180 °C(Press: 15 Torr)
- Density
- 1.206±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 11.06±0.46(Predicted)
- Appearance
- Colorless to light yellow Liquid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 0138AB
- Product name
- Diethyl2-(4-chlorophenyl)malonate
- Packaging
- 250mg
- Price
- $157
- Updated
- 2021/12/16
- Product number
- FD155273
- Product name
- Diethyl 2-(4-chlorophenyl)malonate
- Packaging
- 2
- Price
- $400
- Updated
- 2021/12/16
- Product number
- HCH0142632
- Product name
- DIETHYL-4-CHLOROPHENYL MALONATE
- Purity
- 97.00%
- Packaging
- 1G
- Price
- $465.15
- Updated
- 2021/12/16
- Product number
- FD155273
- Product name
- Diethyl 2-(4-chlorophenyl)malonate
- Packaging
- 5G
- Price
- $500
- Updated
- 2021/12/16
- Product number
- FD155273
- Product name
- Diethyl 2-(4-chlorophenyl)malonate
- Packaging
- 10g
- Price
- $600
- Updated
- 2021/12/16
DIETHYL 4-CHLOROPHENYL MALONATE Chemical Properties,Usage,Production
Synthesis
106-39-8
105-53-3
19677-37-3
The general procedure for the synthesis of diethyl 2-(4-chlorophenyl)malonate from 4-bromochlorobenzene and diethyl malonate is as follows: Example 6: Preparation of diethyl 2-(4-chlorophenyl)malonate by coupling reaction of 4-chlorobromobenzene with diethyl malonate 1. 191.5 mg (1 mmol) of 4-chlorobromobenzene and 160 mg (1 mmol) of diethyl malonate were dissolved in 5 mL of N,N-dimethylformamide (DMF), and 652 mg (2 mmol) of cesium carbonate was added to the reaction system under the protection of an inert gas, and the reaction mixture was stirred for 1 hour. 2. 17.9 mg (4 mol%) of HBPNS ligand and 9.0 mg (4 mol%) of palladium(II) acetate were added to the reaction system and the reaction mixture was subsequently heated to 80 °C and maintained at this temperature for 24 hours. 3. Upon completion of the reaction, post-treatment was performed: 5 mL of water and 10 mL of toluene were added to the reaction mixture, which was fully shaken and separated, and the lower aqueous phase was discarded. The organic phase was washed once more with 5 mL of water to remove residual DMF. 4. Finally, toluene was removed by rotary evaporator to give 230 mg (0.85 mmol, 85% yield) of the target product diethyl 2-(4-chlorophenyl)malonate.
References
[1] Patent: US2008/221350, 2008, A1. Location in patent: Page/Page column 5
DIETHYL 4-CHLOROPHENYL MALONATE Preparation Products And Raw materials
Raw materials
Preparation Products
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