O-Diphenylphosphinylhydroxylamine
- Product Name
- O-Diphenylphosphinylhydroxylamine
- CAS No.
- 72804-96-7
- Chemical Name
- O-Diphenylphosphinylhydroxylamine
- Synonyms
- (AMinooxy)diphenylphosphine oxide;O-(diphenylphosphoryl)hydroxylaMine;aMino diphenylphosphinate;phosphinyL;diphenylphosphinate;O-DiphenyL;Azanyl P,P-diphenylphosphinate;(AMinooxy)diphenylphosphineoxid;TwoPhenylphosphonichydroxylaMine;O-DIPHENYLPHOSPHINYLHYDROXYLAMIN
- CBNumber
- CB7219861
- Molecular Formula
- C12H12NO2P
- Formula Weight
- 233.2
- MOL File
- 72804-96-7.mol
O-Diphenylphosphinylhydroxylamine Property
- Melting point:
- >140℃ (decomposition)
- Boiling point:
- 368.0±25.0 °C(Predicted)
- Density
- 1.25±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO (Slightly), Methanol (Very Slightly, Sonicated)
- pka
- -1.65±0.70(Predicted)
- form
- solid
- color
- white
- InChI
- InChI=1S/C12H12NO2P/c13-15-16(14,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H,13H2
- InChIKey
- SJECIYLGISUNRO-UHFFFAOYSA-N
- SMILES
- P(C1=CC=CC=C1)(C1=CC=CC=C1)(ON)=O
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H312Harmful in contact with skin
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P322Specific measures (see …on this label).
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- D462700
- Product name
- O-Diphenylphosphinylhydroxylamine
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 076297
- Product name
- O-Diphenylphosphinylhydroxylamine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $68
- Updated
- 2021/12/16
- Product number
- 300970
- Product name
- O-(Diphenylphosphinyl)hydroxylamine, 95%
- Packaging
- 1g
- Price
- $71.5
- Updated
- 2021/12/16
- Product number
- FD44822
- Product name
- O-Diphenylphosphinylhydroxylamine
- Packaging
- 5G
- Price
- $85
- Updated
- 2021/12/16
- Product number
- FD44822
- Product name
- O-Diphenylphosphinylhydroxylamine
- Packaging
- 10g
- Price
- $130
- Updated
- 2021/12/16
O-Diphenylphosphinylhydroxylamine Chemical Properties,Usage,Production
Chemical Properties
Light yellow or white powder solid
Uses
Efficient reagent for direct conversion of aldehydes to nitriles in the presence of alcohol, ketone, ester, or amine functionality.
Uses
O-Diphenylphosphinylhydroxylamine is a versatile reactant used in the synthetic preparation of various products such as trans-acylaziridines and aldohydrazones.
Synthesis Reference(s)
Tetrahedron Letters, 23, p. 3835, 1982 DOI: 10.1016/S0040-4039(00)87720-5
Description
O-Diphenylphosphinylhydroxylamine (DPPH) is a versatile electrophilic amination reagent that has been used widely for the amination of stable carbanions, Grignard reagents, and π-electron-rich nitrogen heterocycles. Researchers have used DPPH for the aziridination of enones. Compared to other hydroxylamine derivatives typically stored as hydrochloride salts, this activated phosphinyl reagent exhibits good stability and can be stored indefinitely at 0 ℃. This compound in a single step from hydroxylamine hydrochloride and diphenylphosphinic chloride[1].
General Description
O-(Diphenylphosphinyl)hydroxylamine is a general reagent for electrophilic C-amination, which aminates a variety of stable carbanions and Grignard reagents.
Synthesis
1499-21-4
72804-96-7
The general procedure for the synthesis of diphenylphosphinic acid hydroxylamine from diphenylphosphinic acid chloride is as follows: to a 5 L four-necked round-bottomed flask (RBF) equipped with an overhead stirrer and a thermocouple are added sequentially (1) a solution of 60.85 grams (1.52 moles, 2.4 eq.) of NaOH dissolved in 180 mL of water, (2) 110.12 grams (1.58 moles, 2.5 eq.) of hydroxylamine- HCl dissolved in a solution of 180 mL of water, and (3) 180 mL of dioxane. The mixture was cooled to 0°C in an ice/acetone bath. Subsequently, 150 g of ice was added and a solution of diphenylphosphinic chloride (150.0 g, 0.634 mol, 1 eq.) dissolved in 180 mL of dioxane pre-cooled to about 10°C was added all at once. During the reaction the mixture becomes very viscous with the formation of a white precipitate and vigorous stirring is required. The internal temperature of the reaction rises to 22°C. After continued stirring for 5 to 10 minutes, the reaction mixture was diluted with 2.5 L of ice water and filtered through a large 15 cm diameter sintered funnel. The filter cake was drained on a glass stock for 1 hour, after which it was transferred back into 5 L of RBF. The solid was suspended in 500 mL of ice-cold 0.25 N NaOH solution with vigorous stirring for 5 to 10 min, filtered again, and washed twice with ice water, followed by drying on a porous filter overnight. The partially dried product was dried in a vacuum oven (50 °C, 0.1 Torr) for 12 h, after which it was well pulverized using a mortar and pestle grinder. Finally, the product was dried in a vacuum oven for another 16 hours to give 122 g (82% yield) of the target product diphenylphosphinoylhydroxylamine as a white powder.
References
[1] J. P. Anselm, J. L. Ferrari. “A New Journal for Organic Synthesis: Organic Preparations and Procedures International.” Journal of Chemical Education 48 5 (1971): 349.
O-Diphenylphosphinylhydroxylamine Preparation Products And Raw materials
Raw materials
Preparation Products
O-Diphenylphosphinylhydroxylamine Suppliers
- Tel
- 0512-69209928 18796809688
- Fax
- 0512-68417696
- zhouyingxiang@highfine.com
- Country
- China
- ProdList
- 475
- Advantage
- 75
- Tel
- 21-58226973 18917146209
- Fax
- +86-21-51685790
- Joseph@novapharmas.com
- Country
- China
- ProdList
- 476
- Advantage
- 55
- Tel
- 021-50795510 4000665055
- sales@accelachem.com
- Country
- China
- ProdList
- 10467
- Advantage
- 58
- Tel
- 13393721940
- sales@vcommend.com
- Country
- China
- ProdList
- 9963
- Advantage
- 58
- Tel
- +86-021-50266790 Q2086672224
- Fax
- 021-50266790
- sale@shsendpharm.com
- Country
- China
- ProdList
- 214
- Advantage
- 50
- Tel
- 17602663561
- public@dreamchem.cn
- Country
- China
- ProdList
- 993
- Advantage
- 58
- Tel
- 400-0066400 13621662912
- Fax
- 021-55660885
- sales@jonln.com
- Country
- China
- ProdList
- 1995
- Advantage
- 65
- Tel
- +86-21-20908456
- Fax
- 021-58180499
- sales@BioChemBest.com
- Country
- China
- ProdList
- 6003
- Advantage
- 61
- Tel
- 18515581800 18501085097
- Fax
- 010-89508210
- sales.bj@hwrkchemical.com
- Country
- China
- ProdList
- 9400
- Advantage
- 55
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 010-010-82967028 13522913783
- Fax
- +86-10-82967029
- 2355560935@qq.com
- Country
- China
- ProdList
- 12000
- Advantage
- 60
- Tel
- 0573-85285100 18627885956
- Fax
- 0573-85285100
- isenchem@163.com
- Country
- China
- ProdList
- 9310
- Advantage
- 66
- Tel
- 025-83697070
- Fax
- +86-25-83453306
- info@chemlin.com.cn
- Country
- China
- ProdList
- 16075
- Advantage
- 64
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 010-56541685 13070143590
- Fax
- 010-56541685
- sales@innochem.cn
- Country
- China
- ProdList
- 166
- Advantage
- 57
- Tel
- 0731-85526065 13308475853
- ivy@hnhbsj.com
- Country
- China
- ProdList
- 7247
- Advantage
- 62
- Tel
- 0371-56632527 13838252817
- Fax
- 0371-56635027
- sales@kingsfine.com
- Country
- China
- ProdList
- 98
- Advantage
- 62
- Tel
- 0519-89185693 15312551983
- Fax
- 0519-89185693
- 2410037592@qq.com
- Country
- China
- ProdList
- 261
- Advantage
- 55
- Tel
- 021-33690831-8001 13552411790
- Fax
- 021-33690831
- postmaster@tyjchem.cn
- Country
- China
- ProdList
- 1542
- Advantage
- 55
- Tel
- 021-58388037;21-58388037 13472507714
- 35177634@qq.com;1589045147@qq.com
- Country
- China
- ProdList
- 803
- Advantage
- 55
- Tel
- +86 21 61551611
- Fax
- +86 21 50676805
- Country
- China
- ProdList
- 9891
- Advantage
- 58
- Tel
- 18652989687
- Fax
- +86-25-52131256
- sales@norris-pharm.com
- Country
- China
- ProdList
- 8878
- Advantage
- 55
- Tel
- 025-66113011 17798518460
- Fax
- (1)02557626880
- cfzhang@aikonchem.com
- Country
- China
- ProdList
- 19913
- Advantage
- 55
- Tel
- 150-2103-5486 18017383231
- Fax
- qq：2817624287
- 983544897@qq.com
- Country
- China
- ProdList
- 9342
- Advantage
- 55
- Tel
- 21-33585366 13311639313
- Fax
- +86-21-34979012
- sales@shyrchem.com
- Country
- China
- ProdList
- 806
- Advantage
- 55
- Tel
- 0371-86615086 18203638366 0371-86159066 13526786601
- Fax
- 0371-86159066
- Country
- China
- ProdList
- 2015
- Advantage
- 60
- Tel
- 400-6206333 13167063860
- Fax
- 021-50323701
- anhua.mao@aladdin-e.com
- Country
- China
- ProdList
- 25003
- Advantage
- 65
- Tel
- 021-61552785
- Fax
- 021-55660885
- sales@shshiji.com
- Country
- China
- ProdList
- 9546
- Advantage
- 55
- Tel
- 021-60343070
- Fax
- 021-35122006
- Country
- China
- ProdList
- 12740
- Advantage
- 55
- Tel
- +86-021-50935922
- Fax
- +86-021-33847795
- Country
- China
- ProdList
- 7865
- Advantage
- 55
- Tel
- +86-18921203887
- Fax
- +86-0510-86319635 ; QQ:1622023101
- sales@canalpharm.net
- Country
- China
- ProdList
- 288
- Advantage
- 58
- Tel
- 18939837085
- Fax
- 2880152141(QQ)
- youchemicals@gmail.com
- Country
- China
- ProdList
- 1839
- Advantage
- 55
- Tel
- 400-0066400 13621662912
- Fax
- 021-55660885
- 422131432@qq.com
- Country
- China
- ProdList
- 9979
- Advantage
- 55
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 400-008-9730,021-54359730 400-008-9730
- Fax
- 021-54353864
- info@chemxyz.com
- Country
- China
- ProdList
- 3057
- Advantage
- 60
- Tel
- 023-13650506873 19923294409
- xingcanyaoye@sina.com
- Country
- China
- ProdList
- 1604
- Advantage
- 58
- Tel
- 18957373295
- Fax
- -
- Country
- China
- ProdList
- 1580
- Advantage
- 58
- Tel
- 021-+86-021-38228826 13916602830;
- Fax
- sales@pharmorgsyn.com
- sales@pharmorgsyn.cn
- Country
- China
- ProdList
- 242
- Advantage
- 58
- Tel
- 86-574-27787657
- Fax
- 86-574-27912196
- info@dearchem.com
- Country
- China
- ProdList
- 4613
- Advantage
- 58
- Tel
- 19916721580
- Fax
- QQ：3154870176
- mafarm@126.com
- Country
- China
- ProdList
- 4542
- Advantage
- 58
- Tel
- 0571-87396432
- Fax
- 0571-87396431
- sales@jhechem.com
- Country
- China
- ProdList
- 14912
- Advantage
- 59
- Tel
- 021-61478794
- Fax
- 021-61478794
- sales@hcshhai.com
- Country
- China
- ProdList
- 9793
- Advantage
- 50
- Tel
- 010-1234567 18521000990
- Fax
- 86-021-33275113
- sonyuanchemical@163.com
- Country
- China
- ProdList
- 6479
- Advantage
- 50
- Tel
- 025-57018978 18251899859
- Fax
- 025-57018008
- sales@chalf-pharm.com
- Country
- China
- ProdList
- 5674
- Advantage
- 50
- Tel
- 021-60455363 18019463053
- Fax
- 50966098
- sales@coolpharm.com
- Country
- China
- ProdList
- 12346
- Advantage
- 58
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
- Country
- China
- ProdList
- 51395
- Advantage
- 80
- Tel
- 0570-8789886 18892685668
- Fax
- 0570-8789985
- info@rundongchemical.com
- Country
- China
- ProdList
- 4053
- Advantage
- 60
- Tel
- 86-(0)21-31261262 373522135
- Fax
- 86-(0)21-33250524
- sales@novochemy.com
- Country
- China
- ProdList
- 6498
- Advantage
- 58
- Tel
- 021-34979681; 17701870669
- Fax
- 021-34979681
- 41513101@qq.com
- Country
- China
- ProdList
- 1785
- Advantage
- 55
- Tel
- 021-58088081 Q2635253576
- Fax
- QQ3382968513
- hailey@shsendpharm.com
- Country
- China
- ProdList
- 2081
- Advantage
- 55
View Lastest Price from O-Diphenylphosphinylhydroxylamine manufacturers
- Product
- O-Diphenylphosphinylhydroxylamine 72804-96-7
- Price
- US $1.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2020-01-16
- Product
- O-DIPHENYLPHOSPHINYLHYDROXYLAMINE 72804-96-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1kg,5kg,100kg
- Release date
- 2019-07-04