O-(2-(vinyloxy)ethyl)hydroxylamine

Product Name: O-(2-(vinyloxy)ethyl)hydroxylamine
CAS No.: 391212-29-6
Chemical Name: O-(2-(vinyloxy)ethyl)hydroxylamine
Synonyms: O-[2-(ethenyloxy)ethyl]Hydroxylamine;O-(2-(Vinyloxy);2-(Vinyloxy)ethoxyaMine;Selumetinib Intermediate;1-[2-(Aminooxy)ethoxy]ethylene;O-(2-ETHENOXYETHYL)HYDROXYLAMINE;O-(2-(vinyloxy)ethyl)hydroxylamine;O-(2-(Vinyloxy)ethyl)hydroxylamine95%;HydroxylaMine, O-[2-(ethenyloxy)ethyl]-;methyl 2-((2-fluoro-4-iodophenyl)amino)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxylate
CBNumber: CB02470865
Molecular Formula: C4H9NO2
Formula Weight: 103.12
MOL File: 391212-29-6.mol

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O-(2-(vinyloxy)ethyl)hydroxylamine Property

Boiling point:: 60-65 °C(Press: 20 Torr)
Density: 0.972
storage temp.: -20°C, protect from light, stored under nitrogen
pka: 4.07±0.70(Predicted)
Appearance: Colorless to light yellow Liquid
InChI: InChI=1S/C4H9NO2/c1-2-6-3-4-7-5/h2H,1,3-5H2
InChIKey: XZTSFVPMMQNIAJ-UHFFFAOYSA-N
SMILES: NOCCOC=C
CAS DataBase Reference: 391212-29-6

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Safety

HS Code: 2928009090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: V426010
Product name: O-[2-(Vinyloxy)ethyl]hydroxylamine
Packaging: 100mg
Price: $60
Updated: 2021/12/16

ChemScene

Product number: CS-M0262
Product name: O-(2-(vinyloxy)ethyl)hydroxylamine
Packaging: 1g
Price: $120
Updated: 2021/12/16

Apolloscientific

Product number: OR965288
Product name: O-(2-vinyloxyethyl)hydroxylamine
Purity: 98%
Packaging: 1g
Price: $240
Updated: 2021/12/16

ChemScene

Product number: CS-M0262
Product name: O-(2-(vinyloxy)ethyl)hydroxylamine
Packaging: 5g
Price: $360
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0385224
Product name: O-(2-(VINYLOXY)ETHYL)HYDROXYLAMINE
Purity: 95.00%
Packaging: 5MG
Price: $498.64
Updated: 2021/12/16

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O-(2-(vinyloxy)ethyl)hydroxylamine Chemical Properties,Usage,Production

Uses

O-(2-(vinyloxy)ethyl)hydroxylamine is a pharmaceutical intermediate compound used in the preparation of the antitumour agents Selumetinib and Binimetinib.

Synthesis

1-[2-(Aminooxy)ethoxy]ethylene is prepared as follows:

Step A: 2-(2-(vinyloxy)ethoxy)isoindoline-1,3-dione

To a solution of 2-(vinyloxy)ethanol (20.4 mL, 227 mmol), triphenylphosphine (59.5 g, 227 mmol), and N-hydroxyphthalimide (37.0 g, 227 mmol) in THF (450 mL) was added DEAD (35.9 mL) N2 atmosphere at 0 ??C for ~227 mmol). After stirring for 16 hours at room temperature, the reaction mixture was concentrated in vacuum. The residue was filtered, washed with chloroform and the filtrate was concentrated in vacuum. The residue was purified by SiO2 column chromatography (hexane:EtOAc = 2:1) to give 2-(2-(vinyloxy)ethoxy)isoindoline-1,3-dione (32.5 g, 61.4%) as a yellow solid.

Aqueous solution of methylhydrazine (15.8 mL, 137 mmol) was added dropwise to a solution of 2-(2-(vinyloxy)ethoxy)isoindoline-1,3-dione (32.0 g, 137 mmol) in DCM (96.0 mL). Room temperature. After stirring for 1 hour at room temperature, the resulting suspension was diluted with ether and filtered. The filtrate was concentrated in vacuum. The residue was purified by column chromatography on SiO2 (hexane:EtOAc = 3:2 to 1:1) to give O-(2-(vinyloxy)ethyl)-hydroxylamine (10.7 g, 76%) as a yellow oil.

O-(2-(vinyloxy)ethyl)hydroxylamine Preparation Products And Raw materials

Raw materials

Preparation Products

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O-(2-(vinyloxy)ethyl)hydroxylamine Suppliers

China 122 India 2 United States 7 Global 131

Shanghai potentpharm CO.,Ltd

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View Lastest Price from O-(2-(vinyloxy)ethyl)hydroxylamine manufacturers

Jinan Ruitong Biotech Co., Ltd.

Product: O-(2-(vinyloxy)ethyl)hydroxylamine 391212-29-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1
Release date: 2025-08-28

Sach biotech Co.,Ltd

Product: O-(2-(vinyloxy)ethyl)hydroxylamine 391212-29-6
Price: US $2500.00-1800.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 5mt
Release date: 2025-06-08

Career Henan Chemical Co

Product: O-(2-(vinyloxy)ethyl)hydroxylamine 391212-29-6
Price: US $2.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100g , 1kg, 5kg , 50kg
Release date: 2020-01-07

391212-29-6, O-(2-(vinyloxy)ethyl)hydroxylamineRelated Search:

Selumetinib Sulfate Savolitinib O-Diphenylphosphinylhydroxylamine 2-(AMINOOXY)ETHANOL 1-((2-(dimethoxymethyl)-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)methyl)-4-methylpiperazin-2-one Piperazine, 1-[(6-broMo-3-pyridinyl)Methyl]-4-ethyl- Benzeneacetic acid, 4-fluoro-.alpha.-(1-methylethyl)-, (.alpha.S)- Selumetinib

O-(2-(vinyloxy)ethyl)hydroxylamine

1-[2-(Aminooxy)ethoxy]ethylene

2-(Vinyloxy)ethoxyaMine

HydroxylaMine, O-[2-(ethenyloxy)ethyl]-

O-(2-ETHENOXYETHYL)HYDROXYLAMINE

O-[2-(ethenyloxy)ethyl]Hydroxylamine

O-(2-(Vinyloxy)

Selumetinib Intermediate

O-(2-(Vinyloxy)ethyl)hydroxylamine95%

methyl 2-((2-fluoro-4-iodophenyl)amino)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxylate

391212-29-6