Piperazine, 1-[(6-broMo-3-pyridinyl)Methyl]-4-ethyl-
- Product Name
- Piperazine, 1-[(6-broMo-3-pyridinyl)Methyl]-4-ethyl-
- CAS No.
- 1231930-25-8
- Chemical Name
- Piperazine, 1-[(6-broMo-3-pyridinyl)Methyl]-4-ethyl-
- Synonyms
- Abemaciclib Impurity 5;1-[(6-broMo-3-pyridinyl)Methyl]-4-ethyl-;1-[(6-Bromo-3-pyridyl)methyl]-4-ethylpiperazine;1-((6-bromopyridin-3-yl)methyl)-4-ethylpiperazine;1-[(6-bromo-3-pyridinyl)methyl]-4-ethylPiperazine;Piperazine, 1-[(6-broMo-3-pyridinyl)Methyl]-4-ethyl-
- CBNumber
- CB52668043
- Molecular Formula
- C12H18BrN3
- Formula Weight
- 284.2
- MOL File
- 1231930-25-8.mol
Piperazine, 1-[(6-broMo-3-pyridinyl)Methyl]-4-ethyl- Property
- Boiling point:
- 365.4±37.0 °C(Predicted)
- Density
- 1.328±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 7.67±0.10(Predicted)
- Appearance
- Off-white to light yellow Solid
- InChI
- InChI=1S/C12H18BrN3/c1-2-15-5-7-16(8-6-15)10-11-3-4-12(13)14-9-11/h3-4,9H,2,5-8,10H2,1H3
- InChIKey
- DMNPLEDMMNWHTL-UHFFFAOYSA-N
- SMILES
- N1(CC2=CC=C(Br)N=C2)CCN(CC)CC1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B678523
- Product name
- 1-((6-Bromopyridin-3-yl)methyl)-4-ethylpiperazine
- Packaging
- 500mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- 3276AQ
- Product name
- 1-((6-bromopyridin-3-yl)methyl)-4-ethylpiperazine
- Packaging
- 1g
- Price
- $220.4
- Updated
- 2021/12/16
- Product number
- 171771
- Product name
- 1-((6-Bromopyridin-3-yl)methyl)-4-ethylpiperazine
- Purity
- 95%
- Packaging
- 5g
- Price
- $1733
- Updated
- 2021/12/16
- Product number
- CM170052
- Product name
- 1-((6-Bromopyridin-3-yl)methyl)-4-ethylpiperazine
- Purity
- 97%
- Packaging
- 1g
- Price
- $102
- Updated
- 2021/12/16
- Product number
- CM170052
- Product name
- 1-((6-Bromopyridin-3-yl)methyl)-4-ethylpiperazine
- Purity
- 97%
- Packaging
- 5g
- Price
- $281
- Updated
- 2021/12/16
Piperazine, 1-[(6-broMo-3-pyridinyl)Methyl]-4-ethyl- Chemical Properties,Usage,Production
Synthesis
5308-25-8
149806-06-4
1231930-25-8
To 100 mL of anhydrous dichloromethane (DCM) were added N-ethylpiperazine (10 g, 54 mmol) and 2-bromo-5-formylpyridine (6.20 g, 54.00 mmol) followed by batchwise addition of sodium triacetoxyborohydride (NaHB(OAc)3, 17.20 g, 81.00 mmol). The reaction mixture was stirred at room temperature for 5 hours. Upon completion of the reaction, the mixture was diluted with DCM (100 mL) and the pH was adjusted to 8-10 by adding saturated sodium carbonate (Na2CO3) solution. the mixture was partitioned between water and dichloromethane. The aqueous phase was extracted twice with dichloromethane. The organic phases were combined, washed sequentially with water and brine, dried over anhydrous sodium sulfate (Na2SO4) and concentrated in vacuum. The crude product was purified by silica gel column chromatography (eluent: DCM/MeOH = 50:1) to afford the target compound 1-((6-bromopyridin-3-yl)methyl)-4-ethylpiperazine (8a, 14.00 g, 92.00% yield) as a yellow solid. Mass spectrum (ESI): calculated value C12H18BrN3 [M+H]+ 284, measured value 284.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2018, vol. 28, # 5, p. 974 - 978
[2] Patent: CN105622638, 2016, A. Location in patent: Paragraph 0220
[3] Patent: CN106608879, 2017, A. Location in patent: Paragraph 0142-0145
[4] European Journal of Medicinal Chemistry, 2018, vol. 144, p. 1 - 28
[5] Journal of Medicinal Chemistry, 2017, vol. 60, # 5, p. 1892 - 1915
Piperazine, 1-[(6-broMo-3-pyridinyl)Methyl]-4-ethyl- Preparation Products And Raw materials
Raw materials
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View Lastest Price from Piperazine, 1-[(6-broMo-3-pyridinyl)Methyl]-4-ethyl- manufacturers
- Product
- Abemaciclib Impurity 39 1231930-25-8
- Price
- US $0.00-0.00/mg
- Min. Order
- 10mg
- Purity
- 95%+
- Supply Ability
- 10000
- Release date
- 2025-03-05
- Product
- Piperazine, 1-[(6-broMo-3-pyridinyl)Methyl]-4-ethyl- 1231930-25-8
- Price
- US $6.68/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg-1000kg
- Release date
- 2020-01-08