ChemicalBook > CAS DataBase List > Fluoromethyl phenyl sulfone

Fluoromethyl phenyl sulfone

Product Name
Fluoromethyl phenyl sulfone
CAS No.
20808-12-2
Chemical Name
Fluoromethyl phenyl sulfone
Synonyms
FLUOROMETHYLSULFONYLBENZENE;FLUOROMETHYL PHENYL SULFONE;FluoromethylPhenylSulfone>Phenyl Fluoromethyl Sulfone;Fluoromethanesulfonyl-benzene;Benzene, [(fluoromethyl)sulfonyl]-;fluoromethylsulfonylbenzene - [F70870]
CBNumber
CB7230066
Molecular Formula
C7H7FO2S
Formula Weight
174.19
MOL File
20808-12-2.mol
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Fluoromethyl phenyl sulfone Property

Melting point:
53 °C
Boiling point:
151 °C(Press: 0.3 Torr)
Density 
1.274±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
soluble in Methanol
form 
powder to crystal
color 
White to Almost white
InChI
InChI=1S/C7H7FO2S/c8-6-11(9,10)7-4-2-1-3-5-7/h1-5H,6H2
InChIKey
DENHPZASLKBBHA-UHFFFAOYSA-N
SMILES
C1(S(CF)(=O)=O)=CC=CC=C1
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Safety

Safety Statements 
24/25
HS Code 
29309090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical
Product number
F0341
Product name
Fluoromethyl Phenyl Sulfone
Purity
>98.0%(GC)
Packaging
1g
Price
$206
Updated
2025/07/31
TCI Chemical
Product number
F0341
Product name
Fluoromethyl Phenyl Sulfone
Purity
>98.0%(GC)
Packaging
5g
Price
$694
Updated
2025/07/31
TRC
Product number
F597978
Product name
Fluoromethyl Phenyl Sulfone
Packaging
100mg
Price
$60
Updated
2021/12/16
Chem-Impex
Product number
42384
Product name
Fluoromethylphenylsulfone,98%(GC)
Purity
98%(GC)
Packaging
5G
Price
$713.44
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
JK267664
Product name
Fluoromethyl Phenyl Sulfone
Purity
98%
Packaging
250mg
Price
$51
Updated
2021/12/16
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Fluoromethyl phenyl sulfone Chemical Properties,Usage,Production

Description

Fluoromethyl phenyl sulfone is a useful nucleophilic monofluoromethylation reagent for the synthesis of fluoromethyl alcohols and amines. In the nucleophilic reaction step, strong bases such as LiHMDS and n-BuLi are used to generate the nucleophilic (phenylsulfonyl)fluoromethyl anion. In the desulfonylation step, sodium/mercury amalgam and magnesium are the commonly used reductive reagents. Besides, the addition reaction between fluoromethyl phenyl sulfone and carbonyls can be used to prepare monofluoroaklenes via acylation–elimination.

Uses

Fluoromethyl phenyl sulfone can be used to prepare monofluoroaklenes and chiral α-Monofluoromethyl Amines. Highly stereoselective nucleophilic monofluoromethylation of (R)-(tert-butanesulfinyl)imines with fluoromethyl phenyl sulfone was achieved to afford α-monofluoromethylamines with a nonchelation-controlled stereoselectivity mode. By using the same chemistry, (R)-(tert-butanesulfinyl)imines bearing a terminal tosylate (OTs) group can be converted to α-monofluoromethylated cyclic secondary amines with high stereoselectivity.

Reactions

(1) Monofluoromethylation of aldehydes and ketones.

(2) Monofluoromethylation of aldimines and ketimines.

(3) Monofluoromethylenation of aldehydes and ketones.

(4) (Phenylsulfonyl)fluoromethylation of esters.

References

[1] YA LI. Stereoselective Nucleophilic Monofluoromethylation of N-(tert-Butanesulfinyl)imines with Fluoromethyl Phenyl Sulfone[J]. Organic Letters, 2006. DOI:10.1021/ol060322t.
[2] M. INBASEKARAN. ChemInform Abstract: A NOVEL AND EFFICIENT SYNTHESIS OF FLUOROMETHYL PHENYL SULFONE AND ITS USE AS A FLUOROMETHYL WITTIG EQUIVALENT[J]. ChemInform, 1985. DOI:10.1002/chin.198536160.
[3] GOUVERNEUR V, LOZANO ó. Preparation of Chiral α-Monofluoromethyl Amines Using Fluoromethyl Phenyl Sulfone[C]. 1900. DOI:10.1055/sos-SD-203-00578.

Fluoromethyl phenyl sulfone Preparation Products And Raw materials

Raw materials

Preparation Products

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Fluoromethyl phenyl sulfone Suppliers

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View Lastest Price from Fluoromethyl phenyl sulfone manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
Fluoromethyl phenyl sulfone 20808-12-2
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-09

20808-12-2, Fluoromethyl phenyl sulfoneRelated Search:

PHENYL VALERATE Chlorodimethylphenylsilane Dimethyl sulfoxide Trimethylphenylammonium chloride Dimethyl sulfone Tetradifon Methyltriphenylphosphonium bromide PHENYL RESIN Phenylacetic acid 2-NITRO-4-(TRIFLUOROMETHYLSULFONYL)ANILINE 4-(TRIFLUOROMETHYLSULFONYL)ANILINE 2-CHLORO-5-(TRIFLUOROMETHYLSULFONYL)ANILINE 4-(TRIFLUOROMETHYLSULFONYL)CHLOBENZENE 4-(DIFLUOROMETHYLSULFONYL)NITROBENZENE 4-(DIFLUOROMETHYLSULFONYL)CHLOROBENZENE Phenyl (trifluoromethyl) sulfone 4-CHLOROPHENYL 2-CHLORO-1,1,2-TRIFLUOROETHYL SULFONE 1-CHLORO-2-NITRO-4-TRIFLUOROMETHANESULFONYL-BENZENE

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