Description References
ChemicalBook > CAS DataBase List > Monoethyl fumarate

Monoethyl fumarate

Description References
Product Name
Monoethyl fumarate
CAS No.
2459-05-4
Chemical Name
Monoethyl fumarate
Synonyms
AKOS BBB/201;Ethylfumarat;ETHYL FUMARATE;Monoethyl FuMerate;MONOETHYL FUMARATE;monoethyl furmarate;ETHYL ACID FUMARATE;RARECHEM AL BE 1505;MonoethylFumarate>Mono-Ethyl fuMarate 95%
CBNumber
CB7231119
Molecular Formula
C6H8O4
Formula Weight
144.13
MOL File
2459-05-4.mol
More
Less

Monoethyl fumarate Property

Melting point:
66-68 °C (lit.)
Boiling point:
147 °C/16 mmHg (lit.)
Density 
1.1109
refractive index 
1.4500 (estimate)
storage temp. 
Refrigerator
solubility 
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka
3.45±0.10(Predicted)
form 
Crystalline Powder
color 
Almost white to beige
Water Solubility 
Soluble in water.
BRN 
1723588
Dielectric constant
6.5(23.0℃)
CAS DataBase Reference
2459-05-4(CAS DataBase Reference)
NIST Chemistry Reference
Ethyl hydrogen fumarate(2459-05-4)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
1
HazardClass 
IRRITANT
HS Code 
29171900
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
92585
Product name
mono-Ethyl fumarate
Purity
certified reference material, TraceCERT
Packaging
50mg
Price
$84.1
Updated
2024/03/01
Sigma-Aldrich
Product number
128422
Product name
mono-Ethyl fumarate
Purity
95%
Packaging
25g
Price
$70.9
Updated
2024/03/01
TCI Chemical
Product number
F0359
Product name
Monoethyl Fumarate
Purity
>97.0%(GC)(T)
Packaging
25g
Price
$97
Updated
2024/03/01
TCI Chemical
Product number
F0359
Product name
Monoethyl Fumarate
Purity
>97.0%(GC)(T)
Packaging
250g
Price
$676
Updated
2024/03/01
Usbiological
Product number
012149
Product name
Fumaric Acid Monoethyl Ester
Packaging
1g
Price
$319
Updated
2021/12/16
More
Less

Monoethyl fumarate Chemical Properties,Usage,Production

Description

Monoethyl fumarate is the Monoethyl ester form of fumarate. It is a kind of effective preservative and polymerization agent for macromolecular material. Monoethyl fumarate is capable of inhibiting the growth of bacteria, yeast and mold and prolonging the storage time of feed can. It can also be used for long-term systemic therapy in the treatment of psoriasis (a chronic hyperproliferative inflammatory skin disorder). It is the most active ingredient in the antipsoriasis drug Fumadem. The mechanism is likely to be related to its effect of improvement of keratinocyte differentiation and inhibition of keratinocyte proliferation. Monomethyl fumarate has beneficial effects on the inflamed blood–brain barrier. It increases levels of endogenous antioxidant proteins in brain endothelial cells and reduces expression of VCAM-1 in inflamed brain endothelial cells. Transendothelial monocyte migration is limited upon MMF treatment.

References

Thio, H. B., et al. "Long‐term systemic therapy with dimethylfumarate and monoethylfumarate (Fumaderm®;) in psoriasis." Journal of the European Academy of Dermatology & Venereology 4.1(1995):35-40.
Asadullah, K, et al. "Influence of monomethylfumarate on monocytic cytokine formation--explanation for adverse and therapeutic effects in psoriasis?." Archives of Dermatological Research 289.11(1997):623-30.
Lim, J. L., et al. "Protective effects of monomethyl fumarate at the inflamed blood-brain barrier." Microvascular Research 105(2016):61.
Zhao, Wen Xiu, C. M. Zhang, and X. U. Xue-Ming. "Synthesis and antimicrobial active of monomethyl fumarate." Science & Technology of Food Industry (2008).
Helwa, Inas. "The Mechanism of Monomethylfumarate (MMF) as an Anti-psoriatic Agent." Helwa Inas (2014)

Chemical Properties

ALMOST WHITE TO BEIGE CRYSTALLINE POWDER

Uses

Monoethyl fumarate is the monoethyl ester form of fumaric acid. Monoethyl fumarate is a kind of effective preservative and polymerization agent for macromolecular material.
Monoethyl fumarate (fumaric acid monoethyl ester, monoethyl fumarate) was used in the preparation of photo-crosslinkable macromers. It was also used to synthesize Ugi/intramolecular Diels-Alder (IMDA) cycloaddition products.

Definition

ChEBI: Monomethyl fumarate is a dicarboxylic acid monoester resulting from the formal condensation of one of the carboxy groups of fumaric acid with methanol. Is is a metabolite of dimethyl fumarate and used for the the treatment of patients with relapsing multiple sclerosis (MS). It also induces the NFE2L2 (Nrf2) transcription factor by binding to KEAP1. It has a role as an immunomodulator, an antioxidant and a drug metabolite. It is an enoate ester, a methyl ester and a dicarboxylic acid monoester. It derives from a fumaric acid.

Preparation

Monomethyl fumarate was synthesized by maleic anhydride and methanol. It is used to treat relapsing forms of multiple sclerosis in adults (including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease).

Monoethyl fumarate Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Monoethyl fumarate Suppliers

Wuhan Rongcan Biotechnology Co., Ltd
Tel
18327024450
Fax
183-27024450
Email
2130026275@qq.com
Country
China
ProdList
4570
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Beijing HwrkChemical Technology Co., Ltd
Tel
010-89508211 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
8418
Advantage
55
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44688
Advantage
61
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12390
Advantage
60
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
Advantage
60
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9513
Advantage
66
More
Less

View Lastest Price from Monoethyl fumarate manufacturers

Hebei Yanxi Chemical Co., Ltd.
Product
Monoethyl fumarate 2459-05-4
Price
US $20.00-10.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20 tons
Release date
2023-10-23
Hebei Weibang Biotechnology Co., Ltd
Product
Monoethyl fumarate 2459-05-4
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-24
Hebei Chuanghai Biotechnology Co,.LTD
Product
Monoethyl Fumarate 2459-05-4
Price
US $5.00-2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000kg
Release date
2024-08-23

2459-05-4, Monoethyl fumarateRelated Search:


  • (2E)-4-Ethoxy-4-oxo-2-butenoic acid
  • 2-Butenedioic acid (E)-, monoethyl ester
  • Mono-Ethyl fuMarate 95%
  • Mono-Ethyl FuMarate, 97+%
  • (2E)-2-Butenedioic Acid Monoethyl Ester
  • FuMaric Acid Ethyl Ester
  • Monoethyl FuMerate
  • Monoethyl trans-2-Butenedioate
  • Ethyl Hydrogen Fumarate Fumaric Acid Monoethyl Ester
  • Monoethyl FuMarate (Quetiapine IMpurity R)
  • monoethyl furmarate
  • Fumaric acid monoethyleester
  • 2-Butenedioic acid (2E)-, 1-ethyl ester
  • Quetiapine Impurity 33(Quetiapine EP Impurity R)
  • (E)-4-ethoxy-4-oxo-2-butenoate
  • ETHYL ACID FUMARATE
  • ETHYL HYDROGEN FUMARATE
  • ETHYL FUMARATE
  • ETHYL FUMARATE MONOESTER
  • FUMARIC ACID MONOETHYL ESTER
  • AKOS BBB/201
  • RARECHEM AL BE 1505
  • MONOETHYL FUMARATE
  • (E)-2-ButenedioicAcidMono-EtEster
  • Ethyl hydrogen fumarate, 97+%
  • 2-Butenedioic acid (2E)-, monoethyl ester
  • (2E)-2-Butenedioic Acid 1-Ethyl Ester
  • Ethylfumarat
  • Fumaric Acid Monoethyl Ester 2459-5-4
  • Fumaric acid monoethyl ester, Monoethyl fumarate
  • (E)-2-Butenedioic acid hydrogen 1-ethyl ester
  • Fumaric acid 1-hydrogen 4-ethyl ester
  • Fumaric acid hydrogen 1-ethyl ester
  • Monoethyl trans-ethylene-1,2-dicarboxylate
  • Fumaric acid monoethyl ester,95%
  • (2E)-4-Ethoxy-4-oxobut-2-enoic acid
  • MonoethylFumarate&gt
  • Monoethyl fumarate ISO 9001:2015 REACH
  • Quetiapine EP Impurity R (Fumaric Acid Monoethyl Ester)
  • Monoethyl FumarateQ: What is Monoethyl Fumarate Q: What is the CAS Number of Monoethyl Fumarate Q: What is the storage condition of Monoethyl Fumarate Q: What are the applications of Monoethyl Fumarate
  • 2459-05-4
  • 204296
  • 204-29-6
  • 2459-05-04
  • 9004-32-6
  • C2H5OCOCHCHCOOH
  • C6H804
  • HOOCCHCHCOOC2H5
  • CHCOOC2H52
  • C6H7O4
  • CARBOXYLIC ACID
  • Organic Building Blocks
  • EQ - EZ
  • Esters
  • Carbonyl Compounds
  • C6 to C7
  • Building Blocks
  • Analytical Standards