Ramiprilat
- Product Name
- Ramiprilat
- CAS No.
- 87269-97-4
- Chemical Name
- Ramiprilat
- Synonyms
- Ramipley;RAMIPRILAT;Ramiprilate;HOE 498 Diacid;Ramipril Diacid;RAMIPRILAT HYDRATE;Ramipril Impurity E;Ramiprilat USP/EP/BP;RaMipril EP IMpurity E;RamiprilEPImpurityE-d5
- CBNumber
- CB7231407
- Molecular Formula
- C21H28N2O5
- Formula Weight
- 388.46
- MOL File
- 87269-97-4.mol
Ramiprilat Property
- Melting point:
- 139-141°C
- Boiling point:
- 632.2±55.0 °C(Predicted)
- Density
- 1.273±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 2.20±0.10(Predicted)
- color
- White to Pale Yellow
- Stability:
- Hygroscopic
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 15557
- Product name
- Ramiprilat
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 15557
- Product name
- Ramiprilat
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $270
- Updated
- 2024/03/01
- Product number
- 15557
- Product name
- Ramiprilat
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $477
- Updated
- 2024/03/01
- Product number
- 464518
- Product name
- Ramiprilat|
- Packaging
- 5mg
- Price
- $368
- Updated
- 2021/12/16
- Product number
- R111010
- Product name
- Ramiprilat
- Packaging
- 5mg
- Price
- $235
- Updated
- 2021/12/16
Ramiprilat Chemical Properties,Usage,Production
Description
Ramiprilat is the active metabolite of ramipril and functions as an angiotensin-converting enzyme inhibitor (pKi = 9.08 in human heart) to suppress the conversion of angiotensin I to angiotensin II and the degradation of bradykinin, thereby preventing vasoconstriction. Furthermore, ramiprilat is reported to interfere with the targeting of B2 kinin receptors to endothelial cell membranes further preventing bradykinin signaling. In addition to its cardioprotective effects in both animal models and clinical studies, ramiprilat has been reported to inhibit matrix metalloproteinase-3 and -9 activity in isolated Crohn’s disease fistulas.
Chemical Properties
White to Off-White Solid
Uses
A metabolite of Ramipril (R111000).
Uses
Ramiprilat (Ramipril EP Impurity E) is a metabolite of Ramipril (R111000), and acts as an ACE inhibitor (1). Reduces the need for dialysis among patients previously on angiotensin-converting-enzyme inhibitors (2). Ramipril is used in stroke prevention. (3)
Definition
ChEBI: A dipeptide that is the active metabolite of ramipril. An angiotensin-converting enzyme (ACE) inhibitor, used to treat high blood pressure and congestive heart failure.
in vitro
pretreatment with ramiprilat could significantly attenuate the recovery of b2 kinin receptors in while increasing that from membranes lacking caveolin, and such effect was not because of the inhibition of bradykinin degradation. ramiprilat could also decrease [3h]bradykinin binding to cr membranes. in addition, ramiprilat treatment led to reactivation of the b2 receptor in bradykinin-stimulated cells [1].
in vivo
in previous animal study, when compared with the control rats, diabetic rats showed decreased creatinine clearance rate, increased urinary protein excretion and blood pressure, as well as development of tubulointerstitial fibrosis, glomerulosclerosis, and inflammatory cell infiltration. furthermore, the blocking angiotensin ii with ramipril (the prodrug of ramiprilat) was able to significantly improve all of these parameters [2].
References
[1] t. benzing, i. fleming, a. blaukat, et al. angiotensin-converting enzyme inhibitor ramiprilat interferes with the sequestration of the b2 kinin receptor within the plasma membrane of native endothelial cells. circulation 99(15), 2034-2040 (1999).
[2] li c, yang cw, park cw, ahn hj, kim wy, yoon kh, suh sh, lim sw, cha jh, kim ys, kim j, chang ys, bang bk. long-term treatment with ramipril attenuates renal osteopontin expression in diabetic rats. kidney int. 2003 feb;63(2):454-63.
[3] warner gt, perry cm. ramipril: a review of its use in the prevention of cardiovascular outcomes. drugs. 2002;62(9):1381-405.
Ramiprilat Preparation Products And Raw materials
Raw materials
Preparation Products
Ramiprilat Suppliers
- Tel
- 057685016990 15014006640
- Fax
- 86-21-53086382
- qiangl999@sina.com
- Country
- China
- ProdList
- 111
- Advantage
- 75
- Tel
- 010-82848833 400-666-7788
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 021-20908456
- Fax
- 021-58180499
- sales@BioChemBest.com
- Country
- China
- ProdList
- 6011
- Advantage
- 61
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32344
- Advantage
- 50
- Tel
- 0712-0712-2580635 15527768850
- 1791901229@qq.com
- Country
- China
- ProdList
- 8849
- Advantage
- 52
- Tel
- 1-631-485-4226; 16314854226
- info@bocsci.com
- Country
- United States
- ProdList
- 14059
- Advantage
- 65
- Tel
- +91-22-26355700
- Fax
- +91-22-26355701
- info@clearsynth.com
- Country
- India
- ProdList
- 9685
- Advantage
- 58
- Tel
- 021-33632979 15002134094
- Fax
- 021-33632979
- marketing@targetmol.com
- Country
- China
- ProdList
- 7934
- Advantage
- 58
- Tel
- 0086-571-86217390
- Fax
- 0086-571-86217391
- Sales@gihichem.com
- Country
- China
- ProdList
- 861
- Advantage
- 58
- Tel
- 020-81960175
- Fax
- +1-541-2553641
- min.he@cato-chem.com
- Country
- China
- ProdList
- 1958
- Advantage
- 55
View Lastest Price from Ramiprilat manufacturers
- Product
- Ramiprilat 87269-97-4
- Price
- US $100.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 9000kg/per week
- Release date
- 2021-10-15
- Product
- Ramiprilat 87269-97-4
- Price
- US $2.20/KG
- Min. Order
- 1Kg/Bag
- Purity
- 99%
- Supply Ability
- 20tons
- Release date
- 2021-12-09
- Product
- Ramiprilat 87269-97-4
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-10