4-(4-Methyl-1-piperazinyl)-7-nitrobenzofurazane 3-oxide

ChemicalBook > CAS DataBase List > 4-(4-Methyl-1-piperazinyl)-7-nitrobenzofurazane 3-oxide

4-(4-Methyl-1-piperazinyl)-7-nitrobenzofurazane 3-oxide

Product Name: 4-(4-Methyl-1-piperazinyl)-7-nitrobenzofurazane 3-oxide
CAS No.: 58131-57-0
Chemical Name: 4-(4-Methyl-1-piperazinyl)-7-nitrobenzofurazane 3-oxide
Synonyms: CS-230;XI-006;NSC-207895;NSC 179940;XI-006，NSC-207895;NSC-207895 (XI-006);NSC-207895 NSC207895;XI-006 (NSC207895)=1119;4-(4-Methyl-1-piperazinyl)-7-nitrobenzofurazan 3-oxide;7-(4-Methyl-1-piperazinyl)-4-nitrobenzofurazane 1-oxide
CBNumber: CB72382615
Molecular Formula: C11H13N5O4
Formula Weight: 279.25
MOL File: 58131-57-0.mol

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4-(4-Methyl-1-piperazinyl)-7-nitrobenzofurazane 3-oxide Property

Boiling point:: 487.6±55.0 °C(Predicted)
Density: 1.64
storage temp.: Store at -20°C
solubility: Limited solubility
form: Powder
pka: 6.23±0.42(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 27949
Product name: NSC 207895
Packaging: 1mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 27949
Product name: NSC 207895
Packaging: 25mg
Price: $911
Updated: 2024/03/01

Cayman Chemical

Product number: 27949
Product name: NSC 207895
Packaging: 5mg
Price: $252
Updated: 2024/03/01

Cayman Chemical

Product number: 27949
Product name: NSC 207895
Packaging: 10mg
Price: $456
Updated: 2024/03/01

TRC

Product number: N900558
Product name: NSC-207895
Packaging: 10mg
Price: $450
Updated: 2021/12/16

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4-(4-Methyl-1-piperazinyl)-7-nitrobenzofurazane 3-oxide Chemical Properties,Usage,Production

Description

NSC 207895 is an inhibitor of the p53-binding protein MDMX. It decreases MDMX promoter activity in a reporter assay using HT-1080 cells in a concentration-dependent manner. NSC 207895 (5 μmol/L) decreases the expression and protein levels of MDMX and increases the expression of the p53 target gene CDKN1 (p21) in MCF-7 cells overexpressing MDMX. It also increases the expression of the pro-apoptotic genes PUMA, Bax, and PIG3. NSC 207895 (5 μmol/L) induces apoptosis and decreases cell viability in MCF-7 cells in a p53-dependent manner. It also induces p53-independent apoptosis in wild-type, mutated, and truncated p53 Ewing sarcoma cell lines (IC₅₀s = 98.9-1,613, 236-299, and 121-396 nM, respectively) selectively over wild-type and p53-null osteosarcoma cells (IC₅₀s = 3,690-5,416 and 2,143 nM, respectively).

Uses

NSC-207895 is an anticancer agent and p53 activator. This compound decreases the expression of MDMX but also induced the expression of MDM2. It can also be used in pharmacological activity and therapeutic use of reviving antibiotics in relation to prepared efflux pump inhibitors that interact with AcrA, membrane fusion protein of AcrAB-TolC multidrug efflux pump.

target

E3 ligase MDM2

References

[1] hawes jj, nerva jd, reilly km. novel dual-reporter preclinical screen for antiastrocytoma agents identifies cytostatic and cytotoxic compounds. j biomol screen. 2008 sep;13(8):795-803.
[2] wang h, ma x, ren s, buolamwini jk, yan c. a small-molecule inhibitor of mdmx activates p53 and induces apoptosis. mol cancer ther. 2011 jan;10(1):69-79.
[3] kapitzky l, beltrao p, berens tj, gassner n, zhou c, wüster a, wu j, babu mm, elledge sj, toczyski d, lokey rs, krogan nj. cross-species chemogenomic profiling reveals evolutionarily conserved drug mode of action. mol syst biol. 2010 dec 21;6:451.

4-(4-Methyl-1-piperazinyl)-7-nitrobenzofurazane 3-oxide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-(4-Methyl-1-piperazinyl)-7-nitrobenzofurazane 3-oxide manufacturers

Career Henan Chemical Co

Product: 4-(4-Methyl-1-piperazinyl)-7-nitro-2,1,3-benzoxadiazole 3-oxide 58131-57-0
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 1ton
Release date: 2020-01-10

58131-57-0, 4-(4-Methyl-1-piperazinyl)-7-nitrobenzofurazane 3-oxideRelated Search:

3-Methyl-2-nitrobenzoic acid N-Aminoethylpiperazine Hydroxyethyl piperazine Pifithrin-α (PFTα) N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine TENOVIN-1 Temsirolimus Nutlin-3 Sunitinib Malate

4-(4-Methyl-1-piperazinyl)-7-nitrobenzofurazan 3-oxide

4-(4-Methyl-1-piperazinyl)-7-nitrobenzofurazane 3-oxide

7-(4-Methyl-1-piperazinyl)-4-nitrobenzofurazane 1-oxide

XI-006 (NSC207895)=1119

NSC-207895

NSC-207895 (XI-006)

NSC 179940

4-(4-Methyl-1-piperazinyl)-7-nitro-2,1,3-benzoxadiazole 3-oxide

2,1,3-Benzoxadiazole, 4-(4-methyl-1-piperazinyl)-7-nitro-, 3-oxide

XI-006

CS-230

7-(4-methylpiperazin-1-yl)-4-nitrobenzo[c][1,2,5]oxadiazole 1-oxide

4-(4-Methyl-1-piperazinyl)-7-nitrobenzofurazane 3-oxide USP/EP/BP

XI-006，NSC-207895

NSC-207895 NSC207895

4-(4-methylpiperazin-1-yl)-7-nitro-3-oxido-2,1,3-benzoxadiazol-3-ium

7-(4-Methyl-1-piperazinyl)-4-nitro-2,1,3-benzoxadiazole 1-oxide

58131-57-0

Inhibitors

Inhibitor