2-Isopropyl-2-phenylacetic acid
- Product Name
- 2-Isopropyl-2-phenylacetic acid
- CAS No.
- 3508-94-9
- Chemical Name
- 2-Isopropyl-2-phenylacetic acid
- Synonyms
- Nsc22982;RARECHEM AL BO 0360;2-Phenylisovaleric acid;3-methyl-2-phenyl-butyricaci;à-isopropylphenylacetic acid;α-Isopropylphenylacetic acid;α-Isopropylbenzeneacetic acid;3-methyl-2-phenyl-butyricacid;2-Phenyl-3-methylbutanoic acid;2-ISOPROPYL-2-PHENYLACETIC ACID
- CBNumber
- CB7239771
- Molecular Formula
- C11H14O2
- Formula Weight
- 178.23
- MOL File
- 3508-94-9.mol
2-Isopropyl-2-phenylacetic acid Property
- Melting point:
- 59-61°C
- Boiling point:
- 270.46°C (rough estimate)
- Density
- 1.0292 (rough estimate)
- refractive index
- 1.5167 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 4.26±0.10(Predicted)
- Appearance
- White to off-white Solid
- Water Solubility
- Slightly soluble in water.
- BRN
- 2045915
- CAS DataBase Reference
- 3508-94-9(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- M338635
- Product name
- 3-Methyl-2-phenylbutanoicAcid
- Packaging
- 250mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- CHM0021089
- Product name
- 2-ISOPROPYL-2-PHENYL ACETIC ACID
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $983.52
- Updated
- 2021/12/16
- Product number
- CHM0021089
- Product name
- 2-ISOPROPYL-2-PHENYL ACETIC ACID
- Purity
- 95.00%
- Packaging
- 2.5G
- Price
- $1473.14
- Updated
- 2021/12/16
- Product number
- CHM0021089
- Product name
- 2-ISOPROPYL-2-PHENYL ACETIC ACID
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1928.08
- Updated
- 2021/12/16
- Product number
- 4304AB
- Product name
- 3-Methyl-2-phenylbutyricacid
- Packaging
- 1g
- Price
- $104
- Updated
- 2021/12/16
2-Isopropyl-2-phenylacetic acid Chemical Properties,Usage,Production
Uses
alpha-Isopropylphenylacetic acid is an important raw material and intermediate used in organic synthesis, pharmaceuticals agrochemicals and dyestuff fields.
Synthesis
75-30-9
103-82-2
3508-94-9
GENERAL METHOD: 5 mL of a 0.24 M solution of diorganometallic reagent 1b or 1c (1.2 mmol) was cooled to 0 °C and appropriate arylacetic acid 2 (1.1 mmol) dissolved in 5 mL of anhydrous THF was added. The resulting mixture was stirred vigorously at 0°C for 2 hours. To the cooled dark brown mixture at the same temperature, 1.7 mmol of appropriate electrophilic reagent was added. The reaction mixture was stirred vigorously and allowed to warm slowly to room temperature overnight. Upon completion of the reaction, the reaction was quenched by slow dropwise addition of 15 mL of H2O. The organic solvent was evaporated in vacuum and the residue was extracted with CH2Cl2 (3 × 10 mL). The aqueous phase was acidified with 1N HCl and extracted again with CH2Cl2 (3 × 10 mL). The organic phases were combined, washed sequentially with H2O (1 × 10 mL) and brine (10 mL), dried (Na2SO4), and the solvent evaporated. The crude product was purified and characterized as follows. For the reaction mixture containing crude β-hydroxyacid 2df, 15 mL of 10% HCl (containing about 15 g of crushed ice) was added on quenching and post-treated as described above. After solvent evaporation, the crude product was purified and characterized as follows. Quenching with D2O was performed in the same manner as the above procedure.
References
[1] Organic Syntheses, 2017, vol. 94, p. 1 - 15
[2] Tetrahedron, 2011, vol. 67, # 19, p. 3470 - 3475
[3] Bulletin de la Societe Chimique de France, 1965, p. 1881 - 1888
[4] Journal of the American Chemical Society, 2011, vol. 133, # 31, p. 11936 - 11939
2-Isopropyl-2-phenylacetic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Isopropyl-2-phenylacetic acid manufacturers
- Product
- 2-Isopropyl-2-phenylacetic acid 3508-94-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 97-99%
- Supply Ability
- 1000KGS
- Release date
- 2019-12-19