N-(3-PYRIDYL)-INDOMETHACIN AMIDE
- Product Name
- N-(3-PYRIDYL)-INDOMETHACIN AMIDE
- CAS No.
- 261766-29-4
- Chemical Name
- N-(3-PYRIDYL)-INDOMETHACIN AMIDE
- Synonyms
- N-3PYIA;Indomethacin N-Pyridyl Impurity;N-(3-PYRIDYL)-INDOMETHACIN AMIDE;N-(3-PYRIDYL)-1-P-CHLOROBENZOYL-5-METHOXY-2-METHYLINDOLE-3-ACETAMIDE;N-(3-PYRIDYL)-1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETAMIDE;1-(4-Chlorobenzoyl)-5-Methoxy-2-Methyl-N-3-pyridinyl-1H-indole-3-acetaMide;1H-Indole-3-acetamide, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-N-3-pyridinyl-;2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]-N-pyridin-3-ylacetamide;N-3PyIA, N-(3-Pyridyl)-1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetamide
- CBNumber
- CB7244320
- Molecular Formula
- C24H20ClN3O3
- Formula Weight
- 433.89
- MOL File
- Mol file
N-(3-PYRIDYL)-INDOMETHACIN AMIDE Property
- storage temp.
- −20°C
- solubility
- ≤3mg/ml in ethanol;3mg/ml in DMSO;3mg/ml in dimethyl formamide
- form
- crystalline solid
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- P0865
- Product name
- N-(3-Pyridyl)indomethacinamide
- Purity
- ≥98%
- Packaging
- 5MG
- Price
- $280
- Updated
- 2023/01/07
- Product number
- 70274
- Product name
- N-(3-pyridyl)-Indomethacin amide
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $18
- Updated
- 2024/03/01
- Product number
- 70274
- Product name
- N-(3-pyridyl)-Indomethacin amide
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $73
- Updated
- 2024/03/01
- Product number
- 70274
- Product name
- N-(3-pyridyl)-Indomethacin amide
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $129
- Updated
- 2024/03/01
- Product number
- 70274
- Product name
- N-(3-pyridyl)-Indomethacin amide
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $553
- Updated
- 2024/03/01
N-(3-PYRIDYL)-INDOMETHACIN AMIDE Chemical Properties,Usage,Production
Uses
An aromatic amide of indomethacin recently reported to be a potent and selective reversible inhibitor of COX-2. Inhibits human recombinant COX-2 with IC50 of 0.1 uM.
Biological Activity
n-(3-pyridyl)-indomethacin amide is a reversible, potent and selective cox-2 inhibitor [1].cyclooxygenase (cox) is an enzyme responsible for formation of prostanoids, including thromboxane and prostaglandins such as prostacyclin. cox-1 is the constitutive isoform and is mainly responsible for the synthesis of cytoprotective prostaglandins in the gastrointestinal tract (gi) and of the proaggregatory thromboxane in blood platelets. cox-2 is inducible and short-lived that is stimulated by endotoxin, cytokines, and mitogens. cox-2 plays important roles in prostaglandin biosynthesis in inflammatory cells the central nervous system [1].n-(3-pyridyl)-indomethacin amide (n-3pyia) is a reversible, potent and selective cox-2 inhibitor that inhibits human recombinant cox-2 and ovine cox-1 with ic50 values of 0.052 and >66 μm, respectively. it is over 1300 times less potent as an inhibitor of ovine cox-1. n-(3-pyridyl)-indomethacin amide is the 3-pyridyl amide derivative of indomethacin that shows selective against cox-2 [1].
References
[1]. kalgutkar as, marnett ab, crews bc, et al. ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors. j med chem. 2000 jul 27;43(15):2860-70.
N-(3-PYRIDYL)-INDOMETHACIN AMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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