N-(3-PYRIDYL)-INDOMETHACIN AMIDE
- Product Name
- N-(3-PYRIDYL)-INDOMETHACIN AMIDE
- CAS No.
- 261766-29-4
- Chemical Name
- N-(3-PYRIDYL)-INDOMETHACIN AMIDE
- Synonyms
- N-3PYIA;Indomethacin N-Pyridyl Impurity;N-(3-PYRIDYL)-INDOMETHACIN AMIDE;N-(3-PYRIDYL)-1-P-CHLOROBENZOYL-5-METHOXY-2-METHYLINDOLE-3-ACETAMIDE;N-(3-PYRIDYL)-1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETAMIDE;1-(4-Chlorobenzoyl)-5-Methoxy-2-Methyl-N-3-pyridinyl-1H-indole-3-acetaMide;1H-Indole-3-acetamide, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-N-3-pyridinyl-;2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]-N-pyridin-3-ylacetamide;N-3PyIA, N-(3-Pyridyl)-1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetamide
- CBNumber
- CB7244320
- Molecular Formula
- C24H20ClN3O3
- Formula Weight
- 433.89
- MOL File
- Mol file
N-(3-PYRIDYL)-INDOMETHACIN AMIDE Property
- storage temp.
- −20°C
- solubility
- ≤3mg/ml in ethanol;3mg/ml in DMSO;3mg/ml in dimethyl formamide
- form
- crystalline solid
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- P0865
- Product name
- N-(3-Pyridyl)indomethacinamide
- Purity
- ≥98%
- Packaging
- 5MG
- Price
- $280
- Updated
- 2023/01/07
- Product number
- 70274
- Product name
- N-(3-pyridyl)-Indomethacin amide
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $18
- Updated
- 2024/03/01
- Product number
- 70274
- Product name
- N-(3-pyridyl)-Indomethacin amide
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $73
- Updated
- 2024/03/01
- Product number
- 70274
- Product name
- N-(3-pyridyl)-Indomethacin amide
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $129
- Updated
- 2024/03/01
- Product number
- 70274
- Product name
- N-(3-pyridyl)-Indomethacin amide
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $553
- Updated
- 2024/03/01
N-(3-PYRIDYL)-INDOMETHACIN AMIDE Chemical Properties,Usage,Production
Uses
An aromatic amide of indomethacin recently reported to be a potent and selective reversible inhibitor of COX-2. Inhibits human recombinant COX-2 with IC50 of 0.1 uM.
Biological Activity
n-(3-pyridyl)-indomethacin amide is a reversible, potent and selective cox-2 inhibitor [1].cyclooxygenase (cox) is an enzyme responsible for formation of prostanoids, including thromboxane and prostaglandins such as prostacyclin. cox-1 is the constitutive isoform and is mainly responsible for the synthesis of cytoprotective prostaglandins in the gastrointestinal tract (gi) and of the proaggregatory thromboxane in blood platelets. cox-2 is inducible and short-lived that is stimulated by endotoxin, cytokines, and mitogens. cox-2 plays important roles in prostaglandin biosynthesis in inflammatory cells the central nervous system [1].n-(3-pyridyl)-indomethacin amide (n-3pyia) is a reversible, potent and selective cox-2 inhibitor that inhibits human recombinant cox-2 and ovine cox-1 with ic50 values of 0.052 and >66 μm, respectively. it is over 1300 times less potent as an inhibitor of ovine cox-1. n-(3-pyridyl)-indomethacin amide is the 3-pyridyl amide derivative of indomethacin that shows selective against cox-2 [1].
References
[1]. kalgutkar as, marnett ab, crews bc, et al. ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors. j med chem. 2000 jul 27;43(15):2860-70.
N-(3-PYRIDYL)-INDOMETHACIN AMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
N-(3-PYRIDYL)-INDOMETHACIN AMIDE Suppliers
- Tel
- 010-82848833 400-666-7788
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 821-50328103-801 18930552037
- Fax
- 86-21-50328109
- 3bsc@sina.com
- Country
- China
- ProdList
- 15839
- Advantage
- 69
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 15402
- Advantage
- 60
- Tel
- 020-39119399 18927568969
- Fax
- 020-39119999
- isunpharm@qq.com
- Country
- China
- ProdList
- 4428
- Advantage
- 55
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9806
- Advantage
- 58
- Tel
- +86-400-002-6226 +86-13028896684;
- sales@rrkchem.com
- Country
- China
- ProdList
- 56533
- Advantage
- 58
- Tel
- 021-58432009 400-005-6266
- Fax
- 021-58436166
- marketing1@energy-chemical.com
- Country
- China
- ProdList
- 44808
- Advantage
- 58
- Tel
- 021-69568360 18916172912
- order@med-bio.cn
- Country
- China
- ProdList
- 8140
- Advantage
- 58
- Tel
- 025-58851786 17714337195
- sales@tybiochem.com
- Country
- China
- ProdList
- 7414
- Advantage
- 58
- Tel
- 4008-099-669
- 23419001name@qq.com
- Country
- CHINA
- ProdList
- 68144
- Advantage
- 58