ChemicalBook > CAS DataBase List > SC 57461A

SC 57461A

Product Name
SC 57461A
CAS No.
423169-68-0
Chemical Name
SC 57461A
Synonyms
SC 57461;SC 57461A;SC-57461 Hydrochloride;N-methyl-N-[3-[4-(phenylmethyl)phenoxy]propyl]-β-alaninehydrochloride;3-((3-(4-Benzylphenoxy)propyl)(methyl)amino)propanoic acid hydrochloride;inhibit,SC57461A,SC 57461A,Leukotriene A4,SC-57461A,Inhibitor,Aminopeptidase,orally active,LTA4 hydrolase
CBNumber
CB72446539
Molecular Formula
C20H25NO3.ClH
Formula Weight
363.882
MOL File
423169-68-0.mol
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SC 57461A Property

Melting point:
163-165°C
storage temp. 
Desiccate at +4°C
solubility 
DMSO: >5mg/mL
form 
powder
color 
white to off-white
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
26
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PZ0110
Product name
SC-57461A
Purity
≥98% (HPLC)
Packaging
5mg
Price
$147
Updated
2024/03/01
Sigma-Aldrich
Product number
PZ0110
Product name
SC-57461A
Purity
≥98% (HPLC)
Packaging
25mg
Price
$461
Updated
2024/03/01
Cayman Chemical
Product number
10108
Product name
SC-57461A
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
10108
Product name
SC-57461A
Purity
≥98%
Packaging
5mg
Price
$109
Updated
2024/03/01
Cayman Chemical
Product number
10108
Product name
SC-57461A
Purity
≥98%
Packaging
10mg
Price
$169
Updated
2024/03/01
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SC 57461A Chemical Properties,Usage,Production

Description

Leukotriene A4 (LTA4) hydrolase/aminopeptidase is a bifunctional zinc metalloenzyme that both catalyzes the synthesis of LTB4 from LTA4 and cleaves the chemotactic peptide Pro-Gly-Pro. SC-57461A is a potent, orally active inhibitor of LTA4 hydrolase that blocks ionophore-stimulated LTB4 synthesis in whole blood (IC50 = 49 nM). It blocks both the hydrolase and aminopeptidase activity in vitro. SC-57461A is without effect against other enzymes of the arachidonic acid cascade, including 5-lipoxygenase, LTC4 synthase, COX-1, and COX-2. In a rat model of ionophore-induced peritoneal eicosanoid production, SC-57461A inhibits LTB4 biosynthesis without affecting LTC4 or 6-keto prostaglandin F1α production . Oral or topical pretreatment with SC-57461A before challenge with arachidonic acid blocks ear edema in mice.

Chemical Properties

White Solid

Uses

SC 57461A is a potent and selective inhibitor of LTA4.

Uses

A potent and selective orally active leukotriene A4 hydrolase inhibitor.

Biological Activity

Potent and selective inhibitor of LTA 4 hydrolase. Does not inhibit other enzymes of the arachidonic acid cascade including COX-1, COX-2, LTC 4 synthase and 5-lipoxygenase. Potently inhibits LTB 4 production in whole blood (IC 50 = 49 nM). Orally active.

SC 57461A Preparation Products And Raw materials

Raw materials

Preparation Products

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SC 57461A Suppliers

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423169-68-0, SC 57461ARelated Search:

4-ThiazolecarboxaMide, N-(6-benzoyl-1H-benziMidazol-2-yl)-2-(1-thieno[3,2-d]pyriMidin-4-yl-4-piperidinyl)- 2-AMino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic Acid Ethyl Ester SC-514 SC 66 α,α-Diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile SC 57461A

  • SC-57461 Hydrochloride
  • SC 57461A
  • N-methyl-N-[3-[4-(phenylmethyl)phenoxy]propyl]-β-alaninehydrochloride
  • SC 57461
  • inhibit,SC57461A,SC 57461A,Leukotriene A4,SC-57461A,Inhibitor,Aminopeptidase,orally active,LTA4 hydrolase
  • 3-((3-(4-Benzylphenoxy)propyl)(methyl)amino)propanoic acid hydrochloride
  • 423169-68-0
  • Amines
  • Heterocycles
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pfizer compounds
  • Pharmaceuticals