3-METHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZOIC ACID

Product Name: 3-METHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZOIC ACID
CAS No.: 269409-74-7
Chemical Name: 3-METHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZOIC ACID
Synonyms: Benzoic acid, 3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
CBNumber: CB72448674
Molecular Formula: C14H19BO4
Formula Weight: 262.11
MOL File: 269409-74-7.mol

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3-METHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZOIC ACID Property

Boiling point:: 394.1±35.0 °C(Predicted)
Density: 1.13±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 4.16±0.10(Predicted)
form: solid
color: Red-brown

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Safety

HS Code: 2931900090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-B1244
Product name: 3-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoicacid
Purity: ≥98.0%
Packaging: 1g
Price: $60
Updated: 2021/12/16

ChemScene

Product number: CS-B1244
Product name: 3-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoicacid
Purity: ≥98.0%
Packaging: 5g
Price: $180
Updated: 2021/12/16

AK Scientific

Product number: J90453
Product name: 3-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoicacid
Packaging: 1g
Price: $67
Updated: 2021/12/16

ChemScene

Product number: CS-B1244
Product name: 3-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoicacid
Purity: ≥98.0%
Packaging: 10g
Price: $315
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0152297
Product name: 3-METHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZOIC ACID
Purity: 98.00%
Packaging: 5MG
Price: $499.36
Updated: 2021/12/16

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3-METHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZOIC ACID Chemical Properties,Usage,Production

Synthesis

7697-28-1

73183-34-3

269409-74-7

4-Bromo-3-methylbenzoic acid (1 g, 4.65 mmol) and pinacol ester of bisboronic acid (1.77 g, 6.97 mmol) were used as raw materials in the [1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloride complex with dichloromethane (1:1) (379 mg, 0.46 mmol) and potassium acetate (2.3 g, 23.2 mmol) in the in N,N-dimethylformamide (23 mL) in the presence of potassium acetate (2.3 g, 23.2 mmol) were heated in a microwave reaction system (Biotage Initiator sixty) at 120 °C for 15 min. Upon completion of the reaction, the solvent was removed by evaporation under reduced pressure and the residue was suspended in a 2N HCl/ethyl acetate mixture (40 mL, 1:1 v/v). Filtered through sintered glass, the aqueous phase was extracted with ethyl acetate. The organic layers were combined, washed with brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by fast column chromatography on silica gel, using hexane/ethyl acetate (7:3) as eluent, to afford 3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid (1.1 g, yield 90%) as a white solid.1H-NMR (CDCl3) δ: 1.36 (s, 12H), 2.59 (s, 3H), 7.85-7.90 (m, 3H).

References

[1] Journal of Medicinal Chemistry, 2009, vol. 52, # 17, p. 5531 - 5545
[2] Patent: WO2007/96072, 2007, A2. Location in patent: Page/Page column 36
[3] Patent: WO2008/51493, 2008, A2. Location in patent: Page/Page column 145

3-METHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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3-METHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZOIC ACID Suppliers

China 46 India 2 United States 3 Global 51

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View Lastest Price from 3-METHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZOIC ACID manufacturers

Career Henan Chemical Co

Product: 3-METHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZOIC ACID 269409-74-7
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-26

269409-74-7, 3-METHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZOIC ACIDRelated Search:

(4-FORMYL-2-METHYLPHENYL)BORONIC ACID 3-METHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZOIC ACID 3-METHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZALDEHYDE 4-(Methoxycarbonyl)-2-methylphenylboronic acid pinacol ester (4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol (2-METHYL-4-CARBOXYPHENYL)BORONIC ACID 2-METHYLPHENYLBORONIC ACID, PINACOL ESTER 2,4-DIMETHYLPHENYLBORONIC ACID 4-Carboxylphenylboronic acid pinacol ester

Benzoic acid, 3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-

269409-74-7