(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol

Product Name: (4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol
CAS No.: 302348-51-2
Chemical Name: (4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol
Synonyms: 4-(Hydroxymethyl)benzeneboronic acid pinacol ester;VLOOKUP(C16,[1]Export!$D:$H,5,0);2-[4-(Hydroxymethyl)phenyl]-4,4,5,5-t;4-Hydroxymethylphenylboronic acid, pinacol ester;4-(HydroxyMethyl)phenylboronic acid pinacol ester 97%;4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl Alcohol;(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol;Benzenemethanol, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-;2-[4-(Hydroxymethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
CBNumber: CB01457494
Molecular Formula: C13H19BO3
Formula Weight: 234.1
MOL File: 302348-51-2.mol

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(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol Property

Melting point:: 74-80 °C
Boiling point:: 353.3±25.0 °C(Predicted)
Density: 1.07±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 14.29±0.10(Predicted)
form: powder
color: white
Water Solubility: Insoluble in water.
CAS DataBase Reference: 302348-51-2

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37
WGK Germany: 3
TSCA: No
HS Code: 2931900090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 702927
Product name: 4-(Hydroxymethyl)phenylboronic acid pinacol ester
Purity: 97%
Packaging: 1g
Price: $60.1
Updated: 2025/07/31

Sigma-Aldrich

Product number: 702927
Product name: 4-(Hydroxymethyl)phenylboronic acid pinacol ester
Purity: 97%
Packaging: 5g
Price: $112.97
Updated: 2025/07/31

TCI Chemical

Product number: T3496
Product name: 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl Alcohol
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $40
Updated: 2025/07/31

TCI Chemical

Product number: T3496
Product name: 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl Alcohol
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $125
Updated: 2025/07/31

TRC

Product number: H972570
Product name: 4-(Hydroxymethyl)phenylboronic acid pinacol ester
Packaging: 5g
Price: $120
Updated: 2021/12/16

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(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol Chemical Properties,Usage,Production

Uses

4-(Hydroxymethyl)benzeneboronic acid pinacol ester is used as pharmaceutical intermediate.

Synthesis

873-75-6

73183-34-3

302348-51-2

Using 4-bromobenzyl alcohol (compound 1, 1.0 g, 5.35 mmol) and pinacol ester of bisboronic acid (247 mg, 5.88 mmol) as raw materials, compound 1 was dissolved in 10 mL of anhydrous 1,4-dioxane under nitrogen protection, and potassium acetate and PdCl2 (Dppf) were added as catalysts. The reaction mixture was heated to 85 °C and stirred until the reaction was complete (monitored by thin layer chromatography). After completion of the reaction, the solvent was removed by evaporation under reduced pressure and the residue was extracted by adding ethyl acetate (200 mL) to the residue. The organic phase was dried with anhydrous sodium sulfate and concentrated under reduced pressure to obtain the crude product. The crude product was purified by column chromatography (mobile phase: ethyl acetate/petroleum ether = 1:8 to 1:4) to afford 181 mg of a light yellow oily liquid, 4-(hydroxymethyl)benzeneboronic acid pinacol ester, in 90% yield.

References

[1] Patent: CN108148098, 2018, A. Location in patent: Paragraph 0058; 0059; 0060
[2] Journal of the American Chemical Society, 2018, vol. 140, # 19, p. 6109 - 6121
[3] Patent: US2012/184520, 2012, A1. Location in patent: Page/Page column 17
[4] Patent: CN107445885, 2017, A. Location in patent: Paragraph 0177; 0180
[5] Patent: WO2018/98499, 2018, A1. Location in patent: Page/Page column 215

(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol Preparation Products And Raw materials

Raw materials

Preparation Products

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(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol Suppliers

China 121 France 1 India 3 Japan 1 United Kingdom 1 United States 12 Global 139

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View Lastest Price from (4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: (4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL)METHANOL 302348-51-2
Price: US $3.00-9.00/KG
Min. Order: 0.1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2025-07-02

Career Henan Chemical Co

Product: (4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol 302348-51-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000KGS
Release date: 2019-12-25

302348-51-2, (4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanolRelated Search:

(3-CHLORO-4-METHOXYCARBONYL)BENZENEBORONIC ACID PINACOL ESTER (2-Amino-4-methoxycarbonylphenyl)boronic acid pinacol ester hydrochloride 4-CarBoxy-3-fluoroBenzeneBoronicacid,pinacolester 4-(TERT-BUTOXYCARBONYL)PHENYLBORONIC ACID METHYL 4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZOATE 4-Carboxylphenylboronic acid pinacol ester ETHYL 4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZOATE 3',6'-BIS(4,4,5,5-TETRAMETHYL-1,3,2-DIOXOBOROLAN-2-YL)-SPIRO[ISOBENZOFURAN-1(3H),9'-[9H]XANTHEN]-3-ONE 4-(Methoxycarbonyl)-2-methylphenylboronic acid pinacol ester (4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol 2-METHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZOIC ACID 3-Acetoxy-4-methoxycarbonylphenylboronic acid, pinacol ester 3-Benzyloxy-4-methoxycarbonylphenylboronic acid, pinacol ester 3-METHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZOIC ACID (3-CHLORO-4-ETHOXYCARBONYL)BENZENEBORONIC ACID 3-METHOXY-4-METHOXYCARBONYLPHENYLBORONIC ACID, PINACOL ESTER 3-HYDROXY-4-METHOXYCARBONYLPHENYLBORONIC ACID, PINACOL ESTER 4-(Acetoxymethyl)benzeneboronic acid pinacol ester

4-Hydroxymethylphenylboronic acid, pinacol ester

(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol

4-(Hydroxymethyl)benzeneboronic acid pinacol ester

4-(HydroxyMethyl)phenylboronic acid pinacol ester 97%

2-[4-(Hydroxymethyl)phenyl]-4,4,5,5-t

2-[4-(Hydroxymethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl Alcohol

VLOOKUP(C16,[1]Export!$D:$H,5,0)

Benzenemethanol, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-

302348-51-2

Chemical Synthesis

Organometallic Reagents

Aryl Boronate Esters

Boronate Esters

Boronic Acids and Derivatives

blocks

BoronicAcids