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(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol

Product Name
(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol
CAS No.
302348-51-2
Chemical Name
(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol
Synonyms
4-(Hydroxymethyl)benzeneboronic acid pinacol ester;VLOOKUP(C16,[1]Export!$D:$H,5,0);2-[4-(Hydroxymethyl)phenyl]-4,4,5,5-t;4-Hydroxymethylphenylboronic acid, pinacol ester;4-(HydroxyMethyl)phenylboronic acid pinacol ester 97%;4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl Alcohol;(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol;Benzenemethanol, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-;2-[4-(Hydroxymethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
CBNumber
CB01457494
Molecular Formula
C13H19BO3
Formula Weight
234.1
MOL File
302348-51-2.mol
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(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol Property

Melting point:
74-80 °C
Boiling point:
353.3±25.0 °C(Predicted)
Density 
1.07±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
pka
14.29±0.10(Predicted)
form 
powder
color 
white
Water Solubility 
Insoluble in water.
CAS DataBase Reference
302348-51-2
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-37
WGK Germany 
3
TSCA 
No
HS Code 
2931900090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
702927
Product name
4-(Hydroxymethyl)phenylboronic acid pinacol ester
Purity
97%
Packaging
1g
Price
$60.1
Updated
2025/07/31
Sigma-Aldrich
Product number
702927
Product name
4-(Hydroxymethyl)phenylboronic acid pinacol ester
Purity
97%
Packaging
5g
Price
$112.97
Updated
2025/07/31
TCI Chemical
Product number
T3496
Product name
4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl Alcohol
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$40
Updated
2025/07/31
TCI Chemical
Product number
T3496
Product name
4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl Alcohol
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$125
Updated
2025/07/31
TRC
Product number
H972570
Product name
4-(Hydroxymethyl)phenylboronic acid pinacol ester
Packaging
5g
Price
$120
Updated
2021/12/16
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(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol Chemical Properties,Usage,Production

Uses

4-(Hydroxymethyl)benzeneboronic acid pinacol ester is used as pharmaceutical intermediate.

Synthesis

873-75-6

73183-34-3

302348-51-2

Using 4-bromobenzyl alcohol (compound 1, 1.0 g, 5.35 mmol) and pinacol ester of bisboronic acid (247 mg, 5.88 mmol) as raw materials, compound 1 was dissolved in 10 mL of anhydrous 1,4-dioxane under nitrogen protection, and potassium acetate and PdCl2 (Dppf) were added as catalysts. The reaction mixture was heated to 85 °C and stirred until the reaction was complete (monitored by thin layer chromatography). After completion of the reaction, the solvent was removed by evaporation under reduced pressure and the residue was extracted by adding ethyl acetate (200 mL) to the residue. The organic phase was dried with anhydrous sodium sulfate and concentrated under reduced pressure to obtain the crude product. The crude product was purified by column chromatography (mobile phase: ethyl acetate/petroleum ether = 1:8 to 1:4) to afford 181 mg of a light yellow oily liquid, 4-(hydroxymethyl)benzeneboronic acid pinacol ester, in 90% yield.

References

[1] Patent: CN108148098, 2018, A. Location in patent: Paragraph 0058; 0059; 0060
[2] Journal of the American Chemical Society, 2018, vol. 140, # 19, p. 6109 - 6121
[3] Patent: US2012/184520, 2012, A1. Location in patent: Page/Page column 17
[4] Patent: CN107445885, 2017, A. Location in patent: Paragraph 0177; 0180
[5] Patent: WO2018/98499, 2018, A1. Location in patent: Page/Page column 215

(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol Preparation Products And Raw materials

Raw materials

Preparation Products

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(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol Suppliers

China 121 France 1 India 3 Japan 1 United Kingdom 1 United States 12 Global 139
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28387
Advantage
80
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View Lastest Price from (4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
(4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL)METHANOL 302348-51-2
Price
US $3.00-9.00/KG
Min. Order
0.1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2025-07-02
Career Henan Chemical Co
Product
(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol 302348-51-2
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1000KGS
Release date
2019-12-25

302348-51-2, (4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanolRelated Search:

(3-CHLORO-4-METHOXYCARBONYL)BENZENEBORONIC ACID PINACOL ESTER (2-Amino-4-methoxycarbonylphenyl)boronic acid pinacol ester hydrochloride 4-CarBoxy-3-fluoroBenzeneBoronicacid,pinacolester 4-(TERT-BUTOXYCARBONYL)PHENYLBORONIC ACID METHYL 4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZOATE 4-Carboxylphenylboronic acid pinacol ester ETHYL 4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZOATE 3',6'-BIS(4,4,5,5-TETRAMETHYL-1,3,2-DIOXOBOROLAN-2-YL)-SPIRO[ISOBENZOFURAN-1(3H),9'-[9H]XANTHEN]-3-ONE 4-(Methoxycarbonyl)-2-methylphenylboronic acid pinacol ester (4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol 2-METHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZOIC ACID 3-Acetoxy-4-methoxycarbonylphenylboronic acid, pinacol ester 3-Benzyloxy-4-methoxycarbonylphenylboronic acid, pinacol ester 3-METHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZOIC ACID (3-CHLORO-4-ETHOXYCARBONYL)BENZENEBORONIC ACID 3-METHOXY-4-METHOXYCARBONYLPHENYLBORONIC ACID, PINACOL ESTER 3-HYDROXY-4-METHOXYCARBONYLPHENYLBORONIC ACID, PINACOL ESTER 4-(Acetoxymethyl)benzeneboronic acid pinacol ester

  • 4-Hydroxymethylphenylboronic acid, pinacol ester
  • (4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol
  • 4-(Hydroxymethyl)benzeneboronic acid pinacol ester
  • 4-(HydroxyMethyl)phenylboronic acid pinacol ester 97%
  • 2-[4-(Hydroxymethyl)phenyl]-4,4,5,5-t
  • 2-[4-(Hydroxymethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
  • 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl Alcohol
  • VLOOKUP(C16,[1]Export!$D:$H,5,0)
  • Benzenemethanol, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
  • 302348-51-2
  • Chemical Synthesis
  • Organometallic Reagents
  • Aryl Boronate Esters
  • Boronate Esters
  • Boronic Acids and Derivatives
  • blocks
  • BoronicAcids