ChemicalBook > CAS DataBase List > 2-CHLORO-5-IODO-3-(TRIFLUOROMETHYL)-PYRIDINONE

2-CHLORO-5-IODO-3-(TRIFLUOROMETHYL)-PYRIDINONE

Product Name
2-CHLORO-5-IODO-3-(TRIFLUOROMETHYL)-PYRIDINONE
CAS No.
887707-25-7
Chemical Name
2-CHLORO-5-IODO-3-(TRIFLUOROMETHYL)-PYRIDINONE
Synonyms
2-Chloro-5-iodo-3-(trifluoromethyl);Pyridine, 2-chloro-5-iodo-3-(trifluoromethyl)-;2-CHLORO-5-IODO-3-(TRIFLUOROMETHYL)-PYRIDINONE;6-chloro-3-iodo-5-(trifluoroMethyl)pyridin-4(3H)-one;2-CHLORO-5-IODO-3-(TRIFLUOROMETHYL)-PYRIDINONE ISO 9001：2015 REACH
CBNumber
CB72449646
Molecular Formula
C6H2ClF3IN
Formula Weight
307.44
MOL File
887707-25-7.mol
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2-CHLORO-5-IODO-3-(TRIFLUOROMETHYL)-PYRIDINONE Property

Melting point:
43℃
Boiling point:
261℃
Density 
2.046
Flash point:
112℃
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
form 
Solid
pka
-3.82±0.10(Predicted)
Water Solubility 
Slightly soluble in water.
Sensitive 
Light Sensitive
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Safety

HazardClass 
IRRITANT
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
C381645
Product name
2-Chloro-5-iodo-3-(trifluoromethyl)pyridine
Packaging
500mg
Price
$75
Updated
2021/12/16
AK Scientific
Product number
W9181
Product name
2-Chloro-5-iodo-3-(trifluoromethyl)pyridine
Packaging
5g
Price
$102
Updated
2021/12/16
Matrix Scientific
Product number
057412
Product name
2-Chloro-5-iodo-3-(trifluoromethyl)pyridine
Purity
95%
Packaging
1g
Price
$103
Updated
2021/12/16
Oakwood
Product number
092503
Product name
2-Chloro-5-iodo-3-(trifluoromethyl)pyridine
Packaging
25g
Price
$250
Updated
2021/12/16
Apolloscientific
Product number
PC450103
Product name
2-Chloro-5-iodo-3-(trifluoromethyl)pyridine
Packaging
250mg
Price
$40
Updated
2021/12/16
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2-CHLORO-5-IODO-3-(TRIFLUOROMETHYL)-PYRIDINONE Chemical Properties,Usage,Production

Uses

It is used as pharmaceutical intermediate and as an advanced chemical intermediate.

Synthesis

887707-23-5

887707-25-7

General procedure for the synthesis of 2-chloro-5-iodo-3-(trifluoromethyl)pyridine from 2-hydroxy-5-iodo-3-(trifluoromethyl)pyridine: In a microwave reaction vial, 5-iodo-3-trifluoromethyl-2-pyridinol (1 g, 3.47 mmol) was added to a pre-cooled mixture of POCl3 (1.60 mL) and DMF (1 mL). After sealing the vial, the reaction was heated at 110 °C for 20 min. Upon completion of the reaction, the mixture was cooled to room temperature and slowly poured into ice water. At this point, the product precipitated as a precipitate. The precipitate was collected by filtration, washed with cold water and dried to give 661 mg of the product in the form of a light brown powder in 62% yield. The structure of the product was determined by 1H NMR (500 MHz, CDCl3) δ 8.32 (d, J = 2.0 Hz, 1H), 8.81 (d, J = 2.0 Hz, 1H) and 13C NMR (250 MHz, CDCl3) δ 89.4, 121.2 (q, JC-F = 273.3 Hz), 126.8 (q, JC-F = 33.6 Hz), 144.34, 148.5, 158.7 for confirmation.

References

[1] Patent: WO2015/100613, 2015, A1. Location in patent: Page/Page column 17; 18
[2] Patent: WO2015/100617, 2015, A1. Location in patent: Page/Page column 36; 37
[3] Patent: WO2008/119015, 2008, A2. Location in patent: Page/Page column 48-49
[4] Patent: JP2016/11315, 2016, A. Location in patent: Paragraph 0084
[5] Patent: US9388159, 2016, B2. Location in patent: Page/Page column 20; 21

2-CHLORO-5-IODO-3-(TRIFLUOROMETHYL)-PYRIDINONE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-CHLORO-5-IODO-3-(TRIFLUOROMETHYL)-PYRIDINONE Suppliers

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View Lastest Price from 2-CHLORO-5-IODO-3-(TRIFLUOROMETHYL)-PYRIDINONE manufacturers

Suzhou Nordica Biopharma CO.,LTD
Product
2-chloro-5-iodo-3-(trifluoromethyl)pyridine 887707-25-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
1 tons
Release date
2024-11-15
Dideu Industries Group Limited
Product
2-CHLORO-5-IODO-3-(TRIFLUOROMETHYL)-PYRIDINONE 887707-25-7
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons min
Release date
2021-08-30
Career Henan Chemical Co
Product
2-CHLORO-5-IODO-3-(TRIFLUOROMETHYL)-PYRIDINONE 887707-25-7
Price
US $5.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2020-01-12

887707-25-7, 2-CHLORO-5-IODO-3-(TRIFLUOROMETHYL)-PYRIDINONERelated Search:

3-IODO-1H-PYRIDIN-4-ONE 2-CHLORO-5-IODO-3-(TRIFLUOROMETHYL)-PYRIDINONE

  • 2-CHLORO-5-IODO-3-(TRIFLUOROMETHYL)-PYRIDINONE
  • 6-chloro-3-iodo-5-(trifluoroMethyl)pyridin-4(3H)-one
  • 2-Chloro-5-iodo-3-(trifluoromethyl)
  • Pyridine, 2-chloro-5-iodo-3-(trifluoromethyl)-
  • 2-CHLORO-5-IODO-3-(TRIFLUOROMETHYL)-PYRIDINONE ISO 9001：2015 REACH
  • 887707-25-7
  • C6H2ClF3INO
  • Fluorine series