2-CHLORO-5-IODO-3-(TRIFLUOROMETHYL)-PYRIDINONE
- Product Name
- 2-CHLORO-5-IODO-3-(TRIFLUOROMETHYL)-PYRIDINONE
- CAS No.
- 887707-25-7
- Chemical Name
- 2-CHLORO-5-IODO-3-(TRIFLUOROMETHYL)-PYRIDINONE
- Synonyms
- 2-Chloro-5-iodo-3-(trifluoromethyl);Pyridine, 2-chloro-5-iodo-3-(trifluoromethyl)-;2-CHLORO-5-IODO-3-(TRIFLUOROMETHYL)-PYRIDINONE;6-chloro-3-iodo-5-(trifluoroMethyl)pyridin-4(3H)-one;2-CHLORO-5-IODO-3-(TRIFLUOROMETHYL)-PYRIDINONE ISO 9001：2015 REACH
- CBNumber
- CB72449646
- Molecular Formula
- C6H2ClF3IN
- Formula Weight
- 307.44
- MOL File
- 887707-25-7.mol
2-CHLORO-5-IODO-3-(TRIFLUOROMETHYL)-PYRIDINONE Property
- Melting point:
- 43℃
- Boiling point:
- 261℃
- Density
- 2.046
- Flash point:
- 112℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- Solid
- pka
- -3.82±0.10(Predicted)
- Water Solubility
- Slightly soluble in water.
- Sensitive
- Light Sensitive
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- C381645
- Product name
- 2-Chloro-5-iodo-3-(trifluoromethyl)pyridine
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- W9181
- Product name
- 2-Chloro-5-iodo-3-(trifluoromethyl)pyridine
- Packaging
- 5g
- Price
- $102
- Updated
- 2021/12/16
- Product number
- 057412
- Product name
- 2-Chloro-5-iodo-3-(trifluoromethyl)pyridine
- Purity
- 95%
- Packaging
- 1g
- Price
- $103
- Updated
- 2021/12/16
- Product number
- 092503
- Product name
- 2-Chloro-5-iodo-3-(trifluoromethyl)pyridine
- Packaging
- 25g
- Price
- $250
- Updated
- 2021/12/16
- Product number
- PC450103
- Product name
- 2-Chloro-5-iodo-3-(trifluoromethyl)pyridine
- Packaging
- 250mg
- Price
- $40
- Updated
- 2021/12/16
2-CHLORO-5-IODO-3-(TRIFLUOROMETHYL)-PYRIDINONE Chemical Properties,Usage,Production
Uses
It is used as pharmaceutical intermediate and as an advanced chemical intermediate.
Synthesis
887707-23-5
887707-25-7
General procedure for the synthesis of 2-chloro-5-iodo-3-(trifluoromethyl)pyridine from 2-hydroxy-5-iodo-3-(trifluoromethyl)pyridine: In a microwave reaction vial, 5-iodo-3-trifluoromethyl-2-pyridinol (1 g, 3.47 mmol) was added to a pre-cooled mixture of POCl3 (1.60 mL) and DMF (1 mL). After sealing the vial, the reaction was heated at 110 °C for 20 min. Upon completion of the reaction, the mixture was cooled to room temperature and slowly poured into ice water. At this point, the product precipitated as a precipitate. The precipitate was collected by filtration, washed with cold water and dried to give 661 mg of the product in the form of a light brown powder in 62% yield. The structure of the product was determined by 1H NMR (500 MHz, CDCl3) δ 8.32 (d, J = 2.0 Hz, 1H), 8.81 (d, J = 2.0 Hz, 1H) and 13C NMR (250 MHz, CDCl3) δ 89.4, 121.2 (q, JC-F = 273.3 Hz), 126.8 (q, JC-F = 33.6 Hz), 144.34, 148.5, 158.7 for confirmation.
References
[1] Patent: WO2015/100613, 2015, A1. Location in patent: Page/Page column 17; 18
[2] Patent: WO2015/100617, 2015, A1. Location in patent: Page/Page column 36; 37
[3] Patent: WO2008/119015, 2008, A2. Location in patent: Page/Page column 48-49
[4] Patent: JP2016/11315, 2016, A. Location in patent: Paragraph 0084
[5] Patent: US9388159, 2016, B2. Location in patent: Page/Page column 20; 21
2-CHLORO-5-IODO-3-(TRIFLUOROMETHYL)-PYRIDINONE Preparation Products And Raw materials
Raw materials
Preparation Products
2-CHLORO-5-IODO-3-(TRIFLUOROMETHYL)-PYRIDINONE Suppliers
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- 025-86918202 4000255188
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- 001-857-928-2050 or 1-888-588-9418
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View Lastest Price from 2-CHLORO-5-IODO-3-(TRIFLUOROMETHYL)-PYRIDINONE manufacturers
- Product
- 2-chloro-5-iodo-3-(trifluoromethyl)pyridine 887707-25-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 1 tons
- Release date
- 2024-11-15
- Product
- 2-CHLORO-5-IODO-3-(TRIFLUOROMETHYL)-PYRIDINONE 887707-25-7
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-30
- Product
- 2-CHLORO-5-IODO-3-(TRIFLUOROMETHYL)-PYRIDINONE 887707-25-7
- Price
- US $5.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2020-01-12