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CIS-ZHPROME

Product Name: CIS-ZHPROME
CAS No.: 57653-35-7
Chemical Name: CIS-ZHPROME
Synonyms: CIS-ZHPROME;CIS-ZHPROME USP/EP/BP;Cbz-cis-4-Hydroxy-L-Proline methyl ester;N-CBZ-CIS-4-HYDROXY-L-PROLINE METHYL ESTER;(4S)-1-Cbz-4-hydroxy-L-proline methyl ester;(2S,4S)-N-Cbz-cis-4-hydroxy-L-proline methyl ester;N-CARBOBENZYLOXY-(4S)-HYDROXY-L-PROLINE METHYL ESTER;Methyl (2S,4S)-1-Cbz-4-Hydroxypyrrolidine-2-carboxylate;O1-benzyl O2-methyl (2S,4S)-4-hydroxypyrrolidine-1,2-dic;(2S,4S)-1-Benzyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate
CBNumber: CB72453344
Molecular Formula: C14H17NO5
Formula Weight: 279.29
MOL File: 57653-35-7.mol

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CIS-ZHPROME Property

Melting point:: 80-85°C
Boiling point:: 422.8±45.0 °C(Predicted)
Density: 1.313±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
form: solid
pka: 14.25±0.40(Predicted)
Appearance: White to off-white Solid

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Safety

Hazard Codes: Xi
Risk Statements: 36
Safety Statements: 26
WGK Germany: 2

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H319Causes serious eye irritation
Precautionary statements: P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 705934
Product name: N-Cbz-cis-4-Hydroxy-L-proline methyl ester
Purity: 97%
Packaging: 1g
Price: $223
Updated: 2025/07/31

TRC

Product number: C227565
Product name: N-Cbz-cis-4-Hydroxy-L-proline methyl ester
Packaging: 1g
Price: $100
Updated: 2021/12/16

AK Scientific

Product number: J55654
Product name: N-Cbz-cis-4-Hydroxy-L-proline methyl ester
Packaging: 10g
Price: $135
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H58-1-UH
Product name: N-Cbz-cis-4-hydroxy-L-proline methyl ester
Purity: 97.0%
Packaging: 1g
Price: $190
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: AAA0010546
Product name: N-CBZ-CIS-4-HYDROXY-L-PROLINE METHYL ESTER
Purity: 95.00%
Packaging: 5MG
Price: $497.89
Updated: 2021/12/16

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CIS-ZHPROME Chemical Properties,Usage,Production

Synthesis

1527519-52-3

57653-35-7

Potassium carbonate (9.1 g, 65.8 mmol) was added to a solution of compound D (23 g, 65.8 mmol) in methanol (100 mL) at 0 °C and the reaction mixture was stirred at room temperature for 1 hour. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the completion of the reaction, the mixture was filtered. The filtrate was concentrated under vacuum to remove methanol, and the residue was dissolved in ethyl acetate, washed sequentially with water and brine, dried over anhydrous magnesium sulfate, filtered and concentrated to give the crude product. The crude product was purified by silica gel column chromatography (petroleum ether/ethyl acetate = 4/1 to 1/1 gradient elution) to afford the target product (2S,4S)-N-CBZ-4-hydroxyproline methyl ester (12.6 g, 70% yield) as a light yellow oil.

References

[1] Patent: WO2014/32, 2014, A1. Location in patent: Page/Page column 59

CIS-ZHPROME Preparation Products And Raw materials

Raw materials

Preparation Products

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China 55 India 3 United States 7 Global 65

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57653-35-7, CIS-ZHPROMERelated Search:

Z-L-PROLINE Z-CIS-HYP-OH N-CARBOBENZYLOXY-L-PROLINE METHYL ESTER (S)-1-CBZ-3-PYRROLIDINOL 95 CIS-ZHPROME

CIS-ZHPROME

N-CARBOBENZYLOXY-(4S)-HYDROXY-L-PROLINE METHYL ESTER

N-CBZ-CIS-4-HYDROXY-L-PROLINE METHYL ESTER

(2S,4S)-1-Benzyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate

O1-Benzyl O2-methyl (2S,4S)-4-hydroxypyrrolidine-1,2-dicarboxylate

(2S,4S)-1-(Benzyloxycarbonyl)-2-(methoxycarbonyl)-4-hydroxypyrrolidine

1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 2-methyl 1-(phenylmethyl) ester, (2S,4S)-

1-O-benzyl 2-O-methyl (2S,4S)-4-hydroxypyrrolidine-1,2-dicarboxylate

CIS-ZHPROME USP/EP/BP

(4S)-1-Cbz-4-hydroxy-L-proline methyl ester

Methyl (2S,4S)-1-Cbz-4-Hydroxypyrrolidine-2-carboxylate

(2S,4S)-N-Cbz-cis-4-hydroxy-L-proline methyl ester

Cbz-cis-4-Hydroxy-L-Proline methyl ester

1-benzyl 2-methyl (2S,4S)-4-hydroxypyrrolidine-1,2-dicarboxylate (contain PPh3O)

O1-benzyl O2-methyl (2S,4S)-4-hydroxypyrrolidine-1,2-dic

<i>N</i>-Cbz-<i>cis</i>-4-Hydroxy-<sc>L</sc>-proline methyl ester

57653-35-7