CIS-ZHPROME
- Product Name
- CIS-ZHPROME
- CAS No.
- 57653-35-7
- Chemical Name
- CIS-ZHPROME
- Synonyms
- CIS-ZHPROME;CIS-ZHPROME USP/EP/BP;Cbz-cis-4-Hydroxy-L-Proline methyl ester;N-CBZ-CIS-4-HYDROXY-L-PROLINE METHYL ESTER;(4S)-1-Cbz-4-hydroxy-L-proline methyl ester;(2S,4S)-N-Cbz-cis-4-hydroxy-L-proline methyl ester;N-CARBOBENZYLOXY-(4S)-HYDROXY-L-PROLINE METHYL ESTER;Methyl (2S,4S)-1-Cbz-4-Hydroxypyrrolidine-2-carboxylate;O1-benzyl O2-methyl (2S,4S)-4-hydroxypyrrolidine-1,2-dic;(2S,4S)-1-Benzyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate
- CBNumber
- CB72453344
- Molecular Formula
- C14H17NO5
- Formula Weight
- 279.29
- MOL File
- 57653-35-7.mol
CIS-ZHPROME Property
- Melting point:
- 80-85°C
- Boiling point:
- 422.8±45.0 °C(Predicted)
- Density
- 1.313±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- form
- solid
- pka
- 14.25±0.40(Predicted)
- Appearance
- White to off-white Solid
N-Bromosuccinimide Price
- Product number
- 705934
- Product name
- N-Cbz-cis-4-Hydroxy-L-proline methyl ester
- Purity
- 97%
- Packaging
- 1g
- Price
- $223
- Updated
- 2025/07/31
- Product number
- C227565
- Product name
- N-Cbz-cis-4-Hydroxy-L-proline methyl ester
- Packaging
- 1g
- Price
- $100
- Updated
- 2021/12/16
- Product number
- 4H58-1-UH
- Product name
- N-Cbz-cis-4-hydroxy-L-proline methyl ester
- Purity
- 97.0%
- Packaging
- 250mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- J55654
- Product name
- N-Cbz-cis-4-Hydroxy-L-proline methyl ester
- Packaging
- 10g
- Price
- $135
- Updated
- 2021/12/16
- Product number
- 4H58-1-UH
- Product name
- N-Cbz-cis-4-hydroxy-L-proline methyl ester
- Purity
- 97.0%
- Packaging
- 1g
- Price
- $190
- Updated
- 2021/12/16
CIS-ZHPROME Chemical Properties,Usage,Production
Synthesis
1527519-52-3
57653-35-7
Potassium carbonate (9.1 g, 65.8 mmol) was added to a solution of compound D (23 g, 65.8 mmol) in methanol (100 mL) at 0 °C and the reaction mixture was stirred at room temperature for 1 hour. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the completion of the reaction, the mixture was filtered. The filtrate was concentrated under vacuum to remove methanol, and the residue was dissolved in ethyl acetate, washed sequentially with water and brine, dried over anhydrous magnesium sulfate, filtered and concentrated to give the crude product. The crude product was purified by silica gel column chromatography (petroleum ether/ethyl acetate = 4/1 to 1/1 gradient elution) to afford the target product (2S,4S)-N-CBZ-4-hydroxyproline methyl ester (12.6 g, 70% yield) as a light yellow oil.
References
[1] Patent: WO2014/32, 2014, A1. Location in patent: Page/Page column 59
CIS-ZHPROME Preparation Products And Raw materials
Raw materials
Preparation Products
CIS-ZHPROME Suppliers
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58