N-[(1S,3S)-1-[(ETHOXYMETHOXY)METHYL]-4-(HYDROXYAMINO)-3-METHYL-4-OXOBUTYL]-4-PHENOXYBENZAMIDE

Product Name: N-[(1S,3S)-1-[(ETHOXYMETHOXY)METHYL]-4-(HYDROXYAMINO)-3-METHYL-4-OXOBUTYL]-4-PHENOXYBENZAMIDE
CAS No.: 223472-31-9
Chemical Name: N-[(1S,3S)-1-[(ETHOXYMETHOXY)METHYL]-4-(HYDROXYAMINO)-3-METHYL-4-OXOBUTYL]-4-PHENOXYBENZAMIDE
Synonyms: ONO 4817;MMP Inhibitor V;N-[(1S,3S)-1-[(ETHOXYMETHOXY)METHYL]-4-(HYDROXYAMINO)-3-METHYL-4-OXOBUTYL]-4-PHENOXYBENZAMIDE;Benzamide, N-[(1S,3S)-1-[(ethoxymethoxy)methyl]-4-(hydroxyamino)-3-methyl-4-oxobutyl]-4-phenoxy-
CBNumber: CB72453430
Molecular Formula: C22H28N2O6
Formula Weight: 416.47
MOL File: 223472-31-9.mol

More

Less

N-[(1S,3S)-1-[(ETHOXYMETHOXY)METHYL]-4-(HYDROXYAMINO)-3-METHYL-4-OXOBUTYL]-4-PHENOXYBENZAMIDE Property

Density: 1.192±0.06 g/cm3(Predicted)
storage temp.: Store at RT
solubility: <20.82mg/ml in ethanol; <41.65mg/ml in DMSO
form: solid
pka: 9.55±0.40(Predicted)
color: Off-white

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 444290
Product name: MMP Inhibitor V - CAS 223472-31-9 - Calbiochem
Packaging: 2mg
Price: $216
Updated: 2024/03/01

TRC

Product number: M425433
Product name: MMPInhibitorV
Packaging: 4mg
Price: $235
Updated: 2021/12/16

Usbiological

Product number: 256110
Product name: ONO 4817
Packaging: 10mg
Price: $573
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0000040
Product name: ONO-4817
Purity: 95.00%
Packaging: 10MG
Price: $787.08
Updated: 2021/12/16

ApexBio Technology

Product number: A4437
Product name: ONO4817
Packaging: 10mg
Price: $461
Updated: 2021/12/16

More

Less

N-[(1S,3S)-1-[(ETHOXYMETHOXY)METHYL]-4-(HYDROXYAMINO)-3-METHYL-4-OXOBUTYL]-4-PHENOXYBENZAMIDE Chemical Properties,Usage,Production

Uses

MMP Inhibitor V is a broad-spectrum inhibitor of matrix metalloproteinase (MMPs).

Biological Activity

Broad spectrum MMP inhibitor; K i values are 0.45, 0.73, 1.1, 1.1, 2.1, 42 and 2500 nM for MMP-12, MMP-2, MMP-8, MMP-13, MMP-9, MMP-3 and MMP-7 respectively and IC 50 = 1600 nM for MMP-1). Displays no activity at other proteases up to a concentration of 100 μ M. Exhibits antiangiogenic and anti-invasive properties on lung metastasis of murine renal cell carcinoma.

References

[1]. okamoto, y., et al., a matrix metalloproteinase inhibitor, ono-4817, suppresses the development of aortic intimal hyperplasia in experimental hyperlipidemic rabbit. int heart j, 2007. 48(3): p. 369-78.
[2]. shiraga, m., et al., organ heterogeneity of host-derived matrix metalloproteinase expression and its involvement in multiple-organ metastasis by lung cancer cell lines. cancer res, 2002. 62(20): p. 5967-73.
[3]. ro, y., et al., inhibitory effects of matrix metalloproteinase inhibitor ono-4817 on morphological alterations in chlorhexidine gluconate-induced peritoneal sclerosis rats. nephrol dial transplant, 2007. 22(10): p. 2838-48.

N-[(1S,3S)-1-[(ETHOXYMETHOXY)METHYL]-4-(HYDROXYAMINO)-3-METHYL-4-OXOBUTYL]-4-PHENOXYBENZAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

N-[(1S,3S)-1-[(ETHOXYMETHOXY)METHYL]-4-(HYDROXYAMINO)-3-METHYL-4-OXOBUTYL]-4-PHENOXYBENZAMIDE Suppliers

China 23 United Kingdom 1 United States 7 Global 31

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

Alabiochem Tech.Co., Ltd.

Tel: 0512-58900862 400-0707518
Fax: 0086-512-56765862
Email: sales@alabiochem.com
Country: China
ProdList: 995
Advantage: 59

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8447
Advantage: 60

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

Alabiotech Inc.

Tel: 001-619-354-5251
Fax: 001-855-855-6087
Email: sales@alabiotech-e.com
Country: United States
ProdList: 972
Advantage: 60

Alpha Biopharmaceuticals Co., Ltd

Tel: +86-15542445688
Fax: 0086-411-39042693
Email: sales@alabiochem.com
Country: China
ProdList: 888
Advantage: 58

Alpha Biopharmaceuticals Co., Ltd

Tel: 0411-39042497
Fax: 0411-39042693
Email: sales@alphabiopharm.com
Country: China
ProdList: 1951
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32165
Advantage: 58

Nextpeptide Inc

Tel: +86-0571-81612335 +8613336028439
Email: sales@nextpeptide.com
Country: China
ProdList: 19908
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

223472-31-9, N-[(1S,3S)-1-[(ETHOXYMETHOXY)METHYL]-4-(HYDROXYAMINO)-3-METHYL-4-OXOBUTYL]-4-PHENOXYBENZAMIDERelated Search:

N-[(1S,3S)-1-[(ETHOXYMETHOXY)METHYL]-4-(HYDROXYAMINO)-3-METHYL-4-OXOBUTYL]-4-PHENOXYBENZAMIDE

ONO 4817

MMP Inhibitor V

Benzamide, N-[(1S,3S)-1-[(ethoxymethoxy)methyl]-4-(hydroxyamino)-3-methyl-4-oxobutyl]-4-phenoxy-

223472-31-9