N-[(1S,3S)-1-[(ETHOXYMETHOXY)METHYL]-4-(HYDROXYAMINO)-3-METHYL-4-OXOBUTYL]-4-PHENOXYBENZAMIDE

Product Name: N-[(1S,3S)-1-[(ETHOXYMETHOXY)METHYL]-4-(HYDROXYAMINO)-3-METHYL-4-OXOBUTYL]-4-PHENOXYBENZAMIDE
CAS No.: 223472-31-9
Chemical Name: N-[(1S,3S)-1-[(ETHOXYMETHOXY)METHYL]-4-(HYDROXYAMINO)-3-METHYL-4-OXOBUTYL]-4-PHENOXYBENZAMIDE
Synonyms: ONO 4817;MMP Inhibitor V;N-[(1S,3S)-1-[(ETHOXYMETHOXY)METHYL]-4-(HYDROXYAMINO)-3-METHYL-4-OXOBUTYL]-4-PHENOXYBENZAMIDE;Benzamide, N-[(1S,3S)-1-[(ethoxymethoxy)methyl]-4-(hydroxyamino)-3-methyl-4-oxobutyl]-4-phenoxy-
CBNumber: CB72453430
Molecular Formula: C22H28N2O6
Formula Weight: 416.47
MOL File: 223472-31-9.mol

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N-[(1S,3S)-1-[(ETHOXYMETHOXY)METHYL]-4-(HYDROXYAMINO)-3-METHYL-4-OXOBUTYL]-4-PHENOXYBENZAMIDE Property

Density: 1.192±0.06 g/cm3(Predicted)
storage temp.: Store at RT
solubility: <20.82mg/ml in ethanol; <41.65mg/ml in DMSO
form: solid
pka: 9.55±0.40(Predicted)
color: Off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 444290
Product name: MMP Inhibitor V - CAS 223472-31-9 - Calbiochem
Packaging: 2mg
Price: $216
Updated: 2024/03/01

TRC

Product number: M425433
Product name: MMPInhibitorV
Packaging: 4mg
Price: $235
Updated: 2021/12/16

Usbiological

Product number: 256110
Product name: ONO 4817
Packaging: 10mg
Price: $573
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0000040
Product name: ONO-4817
Purity: 95.00%
Packaging: 10MG
Price: $787.08
Updated: 2021/12/16

ApexBio Technology

Product number: A4437
Product name: ONO4817
Packaging: 10mg
Price: $461
Updated: 2021/12/16

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N-[(1S,3S)-1-[(ETHOXYMETHOXY)METHYL]-4-(HYDROXYAMINO)-3-METHYL-4-OXOBUTYL]-4-PHENOXYBENZAMIDE Chemical Properties,Usage,Production

Uses

MMP Inhibitor V is a broad-spectrum inhibitor of matrix metalloproteinase (MMPs).

Biological Activity

Broad spectrum MMP inhibitor; K i values are 0.45, 0.73, 1.1, 1.1, 2.1, 42 and 2500 nM for MMP-12, MMP-2, MMP-8, MMP-13, MMP-9, MMP-3 and MMP-7 respectively and IC 50 = 1600 nM for MMP-1). Displays no activity at other proteases up to a concentration of 100 μ M. Exhibits antiangiogenic and anti-invasive properties on lung metastasis of murine renal cell carcinoma.

References

[1]. okamoto, y., et al., a matrix metalloproteinase inhibitor, ono-4817, suppresses the development of aortic intimal hyperplasia in experimental hyperlipidemic rabbit. int heart j, 2007. 48(3): p. 369-78.
[2]. shiraga, m., et al., organ heterogeneity of host-derived matrix metalloproteinase expression and its involvement in multiple-organ metastasis by lung cancer cell lines. cancer res, 2002. 62(20): p. 5967-73.
[3]. ro, y., et al., inhibitory effects of matrix metalloproteinase inhibitor ono-4817 on morphological alterations in chlorhexidine gluconate-induced peritoneal sclerosis rats. nephrol dial transplant, 2007. 22(10): p. 2838-48.

N-[(1S,3S)-1-[(ETHOXYMETHOXY)METHYL]-4-(HYDROXYAMINO)-3-METHYL-4-OXOBUTYL]-4-PHENOXYBENZAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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N-[(1S,3S)-1-[(ETHOXYMETHOXY)METHYL]-4-(HYDROXYAMINO)-3-METHYL-4-OXOBUTYL]-4-PHENOXYBENZAMIDE Suppliers

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223472-31-9, N-[(1S,3S)-1-[(ETHOXYMETHOXY)METHYL]-4-(HYDROXYAMINO)-3-METHYL-4-OXOBUTYL]-4-PHENOXYBENZAMIDERelated Search:

N-[(1S,3S)-1-[(ETHOXYMETHOXY)METHYL]-4-(HYDROXYAMINO)-3-METHYL-4-OXOBUTYL]-4-PHENOXYBENZAMIDE

ONO 4817

MMP Inhibitor V

Benzamide, N-[(1S,3S)-1-[(ethoxymethoxy)methyl]-4-(hydroxyamino)-3-methyl-4-oxobutyl]-4-phenoxy-

223472-31-9