ChemicalBook > CAS DataBase List > N-[(1S,3S)-1-[(ETHOXYMETHOXY)METHYL]-4-(HYDROXYAMINO)-3-METHYL-4-OXOBUTYL]-4-PHENOXYBENZAMIDE
N-[(1S,3S)-1-[(ETHOXYMETHOXY)METHYL]-4-(HYDROXYAMINO)-3-METHYL-4-OXOBUTYL]-4-PHENOXYBENZAMIDE
- Product Name
- N-[(1S,3S)-1-[(ETHOXYMETHOXY)METHYL]-4-(HYDROXYAMINO)-3-METHYL-4-OXOBUTYL]-4-PHENOXYBENZAMIDE
- CAS No.
- 223472-31-9
- Chemical Name
- N-[(1S,3S)-1-[(ETHOXYMETHOXY)METHYL]-4-(HYDROXYAMINO)-3-METHYL-4-OXOBUTYL]-4-PHENOXYBENZAMIDE
- Synonyms
- ONO 4817;MMP Inhibitor V;N-[(1S,3S)-1-[(ETHOXYMETHOXY)METHYL]-4-(HYDROXYAMINO)-3-METHYL-4-OXOBUTYL]-4-PHENOXYBENZAMIDE;Benzamide, N-[(1S,3S)-1-[(ethoxymethoxy)methyl]-4-(hydroxyamino)-3-methyl-4-oxobutyl]-4-phenoxy-
- CBNumber
- CB72453430
- Molecular Formula
- C22H28N2O6
- Formula Weight
- 416.47
- MOL File
- 223472-31-9.mol
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N-[(1S,3S)-1-[(ETHOXYMETHOXY)METHYL]-4-(HYDROXYAMINO)-3-METHYL-4-OXOBUTYL]-4-PHENOXYBENZAMIDE Property
- Density
- 1.192±0.06 g/cm3(Predicted)
- storage temp.
- Store at RT
- solubility
- <20.82mg/ml in ethanol; <41.65mg/ml in DMSO
- form
- solid
- pka
- 9.55±0.40(Predicted)
- color
- Off-white
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 444290
- Product name
- MMP Inhibitor V - CAS 223472-31-9 - Calbiochem
- Packaging
- 2mg
- Price
- $216
- Updated
- 2024/03/01
TRC
- Product number
- M425433
- Product name
- MMPInhibitorV
- Packaging
- 4mg
- Price
- $235
- Updated
- 2021/12/16
Usbiological
- Product number
- 256110
- Product name
- ONO 4817
- Packaging
- 10mg
- Price
- $573
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- INB0000040
- Product name
- ONO-4817
- Purity
- 95.00%
- Packaging
- 10MG
- Price
- $787.08
- Updated
- 2021/12/16
ApexBio Technology
- Product number
- A4437
- Product name
- ONO4817
- Packaging
- 10mg
- Price
- $461
- Updated
- 2021/12/16
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N-[(1S,3S)-1-[(ETHOXYMETHOXY)METHYL]-4-(HYDROXYAMINO)-3-METHYL-4-OXOBUTYL]-4-PHENOXYBENZAMIDE Chemical Properties,Usage,Production
Uses
MMP Inhibitor V is a broad-spectrum inhibitor of matrix metalloproteinase (MMPs).
Biological Activity
Broad spectrum MMP inhibitor; K i values are 0.45, 0.73, 1.1, 1.1, 2.1, 42 and 2500 nM for MMP-12, MMP-2, MMP-8, MMP-13, MMP-9, MMP-3 and MMP-7 respectively and IC 50 = 1600 nM for MMP-1). Displays no activity at other proteases up to a concentration of 100 μ M. Exhibits antiangiogenic and anti-invasive properties on lung metastasis of murine renal cell carcinoma.
References
[1]. okamoto, y., et al., a matrix metalloproteinase inhibitor, ono-4817, suppresses the development of aortic intimal hyperplasia in experimental hyperlipidemic rabbit. int heart j, 2007. 48(3): p. 369-78.
[2]. shiraga, m., et al., organ heterogeneity of host-derived matrix metalloproteinase expression and its involvement in multiple-organ metastasis by lung cancer cell lines. cancer res, 2002. 62(20): p. 5967-73.
[3]. ro, y., et al., inhibitory effects of matrix metalloproteinase inhibitor ono-4817 on morphological alterations in chlorhexidine gluconate-induced peritoneal sclerosis rats. nephrol dial transplant, 2007. 22(10): p. 2838-48.
N-[(1S,3S)-1-[(ETHOXYMETHOXY)METHYL]-4-(HYDROXYAMINO)-3-METHYL-4-OXOBUTYL]-4-PHENOXYBENZAMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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N-[(1S,3S)-1-[(ETHOXYMETHOXY)METHYL]-4-(HYDROXYAMINO)-3-METHYL-4-OXOBUTYL]-4-PHENOXYBENZAMIDE Suppliers
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