8-CHLORO-2-METHYLIMIDAZO[1,2-A]PYRAZINE
- Product Name
- 8-CHLORO-2-METHYLIMIDAZO[1,2-A]PYRAZINE
- CAS No.
- 85333-43-3
- Chemical Name
- 8-CHLORO-2-METHYLIMIDAZO[1,2-A]PYRAZINE
- Synonyms
- 8-chloro-2-MethyliMidazo[1;8-CHLORO-2-METHYLIMIDAZO[1,2-A]PYRAZINE;8-Chloro-2-MethyliMidazol[1,2-a]pyrazine;Imidazo[1,2-a]pyrazine, 8-chloro-2-methyl-
- CBNumber
- CB72453753
- Molecular Formula
- C7H6ClN3
- Formula Weight
- 167.6
- MOL File
- 85333-43-3.mol
8-CHLORO-2-METHYLIMIDAZO[1,2-A]PYRAZINE Property
- Density
- 1.43±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 2.51±0.30(Predicted)
- Appearance
- Light brown to brown Solid
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C602090
- Product name
- 8-Chloro-2-methylimidazo[1,2-a]pyrazine
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- C602090
- Product name
- 8-Chloro-2-methylimidazo[1,2-a]pyrazine
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- C602090
- Product name
- 8-Chloro-2-methylimidazo[1,2-a]pyrazine
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FC142636
- Product name
- 8-Chloro-2-methylimidazo[1,2-a]pyrazine
- Packaging
- 500mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- FC142636
- Product name
- 8-Chloro-2-methylimidazo[1,2-a]pyrazine
- Packaging
- 1g
- Price
- $177
- Updated
- 2021/12/16
8-CHLORO-2-METHYLIMIDAZO[1,2-A]PYRAZINE Chemical Properties,Usage,Production
Synthesis
6863-73-6
78-95-5
85333-43-3
The reaction was carried out with 2-amino-3-chloropyrazine (48.7 g, 375.8 mmol) and chloroacetone (120 mL, 1504.5 mmol) in a sealed tube with stirring for 16 h at 90 °C under light protection. Upon completion of the reaction, it was cooled to room temperature, ether (Et2O) was added and the solid product formed was collected by filtration. After washing the solid with additional ether, it was suspended in saturated sodium carbonate solution and extracted with dichloromethane (DCM). The organic layer was separated, dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated in vacuum to remove the solvent. The crude product was purified by recrystallization from ether to give Intermediate 4 (43.2 g, 68% yield) as a white solid, which could be used in subsequent reactions without further purification. The melting point of the intermediate was 133.5-138.6 °C (determined by WRS-2A melting point apparatus).
References
[1] Patent: WO2011/110545, 2011, A1. Location in patent: Page/Page column 73-74
[2] Patent: US2012/329792, 2012, A1. Location in patent: Page/Page column 33-34
[3] Journal of Medicinal Chemistry, 2014, vol. 57, # 10, p. 4196 - 4212
[4] Patent: US2015/203498, 2015, A1. Location in patent: Paragraph 0167; 0168
[5] Patent: WO2016/185342, 2016, A1. Location in patent: Page/Page column 39
8-CHLORO-2-METHYLIMIDAZO[1,2-A]PYRAZINE Preparation Products And Raw materials
Raw materials
Preparation Products
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