8-Chloro-imidazo[1,2-a]pyrazine

Uses

Product Name: 8-Chloro-imidazo[1,2-a]pyrazine
CAS No.: 69214-33-1
Chemical Name: 8-Chloro-imidazo[1,2-a]pyrazine
Synonyms: 8-Chloro-imidazo[1,2-a]pyrazine;MIDAZO[1,2-A]PYRAZINE, 8-CHLORO-;Imidazo[1,2-a]pyrazine, 8-chloro-;8-chloroimidazo[1,2-a]pyrazine hydrobromide
CBNumber: CB41113420
Molecular Formula: C6H4ClN3
Formula Weight: 153.57
MOL File: 69214-33-1.mol

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8-Chloro-imidazo[1,2-a]pyrazine Property

Density: 1.51±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 1.50±0.30(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C6H4ClN3/c7-5-6-9-2-4-10(6)3-1-8-5/h1-4H
InChIKey: PREWHWRWNMLCNH-UHFFFAOYSA-N
SMILES: C12=NC=CN1C=CN=C2Cl

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Safety

HazardClass: IRRITANT
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C368458
Product name: 8-Chloroimidazo[1,2-a]pyrazine
Packaging: 100mg
Price: $75
Updated: 2021/12/16

Apolloscientific

Product number: OR300248
Product name: 8-Chloroimidazo[1,2-a]pyrazine
Packaging: 1g
Price: $40
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: C11644
Product name: 8-Chloroimidazo[1,2-a]pyrazine
Purity: 95%
Packaging: 1g
Price: $40
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-5-JT
Product name: 8-Chloroimidazo[1,2-a]pyrazine
Packaging: 1g
Price: $44
Updated: 2021/12/16

AK Scientific

Product number: X0309
Product name: 8-Chloro-imidazo[1,2-a]pyrazine
Packaging: 1g
Price: $105
Updated: 2021/12/16

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8-Chloro-imidazo[1,2-a]pyrazine Chemical Properties,Usage,Production

Uses

8-Chloroimidazo[1,2-a]pyrazine is a useful research chemical.

Synthesis

6863-73-6

2032-35-1

69214-33-1

GENERAL STEPS: Mix 48% aqueous hydrogen bromide solution (0.893 mL) with distilled water (9 mL) and add 2-bromo-1,1-diethoxyethane (5.98 mL, 38.5 mmol). It was heated and stirred under reflux conditions for 1 hour. After completion of the reaction, distilled water and ether were added to the reaction mixture for partitioning. The aqueous phase was extracted with ether, all organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The resulting residue was mixed with a solution of 3-chloropyrazin-2-amine (2.0 g, 15.4 mmol) in dimethoxyethane (22 mL) and 48% aqueous hydrogen bromide (0.3 mL) was added. It was heated and stirred under reflux conditions for 3 hours. At the end of the reaction, the solid product was collected by filtration and washed with ether to afford 8-chloroimidazo[1,2-a]pyrazine (2.07 g, 88% yield) as a black solid. Mass spectrum (ESI) m/z = 154 ([M + H]+).

References

[1] Patent: US2012/59162, 2012, A1. Location in patent: Page/Page column 38-39
[2] Patent: WO2010/69684, 2010, A1. Location in patent: Page/Page column 96
[3] Patent: WO2011/110545, 2011, A1. Location in patent: Page/Page column 73
[4] Patent: US2012/329792, 2012, A1. Location in patent: Page/Page column 33
[5] Patent: WO2009/12482, 2009, A2. Location in patent: Page/Page column 90

8-Chloro-imidazo[1,2-a]pyrazine Preparation Products And Raw materials

Raw materials

Preparation Products

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8-Chloro-imidazo[1,2-a]pyrazine Suppliers

China 133 India 2 United Kingdom 2 United States 10 Global 147

Shanghai Amico Chemicals Co. LTD

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View Lastest Price from 8-Chloro-imidazo[1,2-a]pyrazine manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 8-Chloroimidazo[1,2-a]pyrazine 69214-33-1
Price: US $1.10-9.90/KG
Min. Order: 1KG
Purity: 99% min
Supply Ability: 100kg
Release date: 2025-08-18

Career Henan Chemical Co

Product: 8-Chloro-imidazo[1,2-a]pyrazine 69214-33-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-31

69214-33-1, 8-Chloro-imidazo[1,2-a]pyrazineRelated Search:

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8-Chloro-imidazo[1,2-a]pyrazine

8-chloroimidazo[1,2-a]pyrazine hydrobromide

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69214-33-1