2-[(3-CHLOROPHENYL)METHOXY]-6-(1-PIPERAZINYL)PYRAZINE HYDROCHLORIDE

Product Name: 2-[(3-CHLOROPHENYL)METHOXY]-6-(1-PIPERAZINYL)PYRAZINE HYDROCHLORIDE
CAS No.: 479683-64-2
Chemical Name: 2-[(3-CHLOROPHENYL)METHOXY]-6-(1-PIPERAZINYL)PYRAZINE HYDROCHLORIDE
Synonyms: CS-687;CP809101;CP-809101;CP 809101;CP809101/CP-809101;CP 809101 hydrochlor;CP-809102 hydrochloride;CP 809101 HYDROCHLORIDE;Pyrazine, 2-[(3-chlorophenyl)methoxy]-6-(1-piperazinyl)-;6'-(3-Chlorobenzyloxy)-3,4,5,6-tetrahydro-2H-[1,2']bipyrazine
CBNumber: CB72454336
Molecular Formula: C15H17ClN4O
Formula Weight: 304.77
MOL File: 479683-64-2.mol

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2-[(3-CHLOROPHENYL)METHOXY]-6-(1-PIPERAZINYL)PYRAZINE HYDROCHLORIDE Property

Boiling point:: 486.6±45.0 °C(Predicted)
Density: 1.265±0.06 g/cm3(Predicted)
storage temp.: Desiccate at RT
solubility: DMSO
form: powder
pka: 8.24±0.10(Predicted)
color: white to beige

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PZ0378
Product name: CP-809,101 fumarate
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $83.7
Updated: 2024/03/01

Sigma-Aldrich

Product number: PZ0378
Product name: CP-809,101 fumarate
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $202.8
Updated: 2024/03/01

Tocris

Product number: 3041
Product name: CP809101hydrochloride
Purity: ≥99%(HPLC)
Packaging: 50
Price: $658
Updated: 2021/12/16

Tocris

Product number: 3041
Product name: CP809101hydrochloride
Purity: ≥99%(HPLC)
Packaging: 10
Price: $165
Updated: 2021/12/16

Usbiological

Product number: 255040
Product name: CP 809101 hydrochloride
Packaging: 10mg
Price: $403
Updated: 2021/12/16

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2-[(3-CHLOROPHENYL)METHOXY]-6-(1-PIPERAZINYL)PYRAZINE HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

CP 809101 is a potent and selective SR-2C and 5-HT2C agonist.

Biological Activity

Potent and selective 5-HT 2C receptor agonist (pEC 50 values are 9.96, 7.19 and 6.81 for human 5-HT 2C , 5-HT 2B and 5-HT 2A receptors respectively). Displays antipsychotic activity; suppresses condition avoidance responding (CAR) and inhibits PCP and amphetamine-stimulated hyperactivity in rats following subcutaneous administration.

Biochem/physiol Actions

CP-809,101 is a potent and high-affinity 5-hydroxytryptamine receptor 2C (5-HT2C) full agonist with only weaker partial agonist activity toward 5-HT2A & 5-HT2B (cellular Ca2+ mobilization EC50 in nM/efficiency = 0.11/93% and 0.06/97% with human and rat 5-HT2C, respectively; 153/67%/human 5HT2A, 65.3/57%/human 5HT2B, 119/79%/rat 5HT2A) and much reduced or little affinity toward other receptors, ion channels and uptake sites tested. CP-809,101 exhibits antipsychotic efficacy in reducing conditioned avoidance response/CAR (ED50 = 4.8 mg/kg s.c.) and locomotor activity (ED50 in mg/kg via s.c. = 2/rats, 1/mice; no effect up to 10 mg/kg in 5-HT2C-knockout mice), while oral administration is reported to suppress spontaneous and nocturnal food intake as well as fasting-induced refeeding in rats (～8% and ～24% reduction of cumulative food intake and body weight in 4 days, respectively; 30 mg/kg/day p.o.).

2-[(3-CHLOROPHENYL)METHOXY]-6-(1-PIPERAZINYL)PYRAZINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-[(3-CHLOROPHENYL)METHOXY]-6-(1-PIPERAZINYL)PYRAZINE HYDROCHLORIDE Suppliers

China 34 Switzerland 1 United Kingdom 1 United States 9 Global 45

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479683-64-2, 2-[(3-CHLOROPHENYL)METHOXY]-6-(1-PIPERAZINYL)PYRAZINE HYDROCHLORIDERelated Search:

2-[(3-CHLOROPHENYL)METHOXY]-6-(1-PIPERAZINYL)PYRAZINE HYDROCHLORIDE 6-(BENZYLOXY)PYRAZIN-2-AMINE 6-Methoxypyrazinamine

2-[(3-CHLOROPHENYL)METHOXY]-6-(1-PIPERAZINYL)PYRAZINE HYDROCHLORIDE

CP 809101 HYDROCHLORIDE

CP 809101

CP809101

CP-809101

6'-(3-Chlorobenzyloxy)-3,4,5,6-tetrahydro-2H-[1,2']bipyrazine

CP809101/CP-809101

CS-687

Pyrazine, 2-[(3-chlorophenyl)methoxy]-6-(1-piperazinyl)-

CP 809101 hydrochlor

CP-809102 hydrochloride

479683-64-2

C15H17N4OClHCl

Potent and selective 5-HT2C receptor agonist