ChemicalBook > CAS DataBase List > 2-[(3-CHLOROPHENYL)METHOXY]-6-(1-PIPERAZINYL)PYRAZINE HYDROCHLORIDE

2-[(3-CHLOROPHENYL)METHOXY]-6-(1-PIPERAZINYL)PYRAZINE HYDROCHLORIDE

Product Name
2-[(3-CHLOROPHENYL)METHOXY]-6-(1-PIPERAZINYL)PYRAZINE HYDROCHLORIDE
CAS No.
479683-64-2
Chemical Name
2-[(3-CHLOROPHENYL)METHOXY]-6-(1-PIPERAZINYL)PYRAZINE HYDROCHLORIDE
Synonyms
CS-687;CP809101;CP-809101;CP 809101;CP809101/CP-809101;CP 809101 hydrochlor;CP-809102 hydrochloride;CP 809101 HYDROCHLORIDE;Pyrazine, 2-[(3-chlorophenyl)methoxy]-6-(1-piperazinyl)-;6'-(3-Chlorobenzyloxy)-3,4,5,6-tetrahydro-2H-[1,2']bipyrazine
CBNumber
CB72454336
Molecular Formula
C15H17ClN4O
Formula Weight
304.77
MOL File
479683-64-2.mol
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2-[(3-CHLOROPHENYL)METHOXY]-6-(1-PIPERAZINYL)PYRAZINE HYDROCHLORIDE Property

Boiling point:
486.6±45.0 °C(Predicted)
Density 
1.265±0.06 g/cm3(Predicted)
storage temp. 
Desiccate at RT
solubility 
DMSO
form 
powder
pka
8.24±0.10(Predicted)
color 
white to beige
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PZ0378
Product name
CP-809,101 fumarate
Purity
≥98% (HPLC)
Packaging
5mg
Price
$83.7
Updated
2024/03/01
Sigma-Aldrich
Product number
PZ0378
Product name
CP-809,101 fumarate
Purity
≥98% (HPLC)
Packaging
25mg
Price
$202.8
Updated
2024/03/01
Tocris
Product number
3041
Product name
CP809101hydrochloride
Purity
≥99%(HPLC)
Packaging
50
Price
$658
Updated
2021/12/16
Tocris
Product number
3041
Product name
CP809101hydrochloride
Purity
≥99%(HPLC)
Packaging
10
Price
$165
Updated
2021/12/16
Usbiological
Product number
255040
Product name
CP 809101 hydrochloride
Packaging
10mg
Price
$403
Updated
2021/12/16
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2-[(3-CHLOROPHENYL)METHOXY]-6-(1-PIPERAZINYL)PYRAZINE HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

CP 809101 is a potent and selective SR-2C and 5-HT2C agonist.

Biological Activity

Potent and selective 5-HT 2C receptor agonist (pEC 50 values are 9.96, 7.19 and 6.81 for human 5-HT 2C , 5-HT 2B and 5-HT 2A receptors respectively). Displays antipsychotic activity; suppresses condition avoidance responding (CAR) and inhibits PCP and amphetamine-stimulated hyperactivity in rats following subcutaneous administration.

Biochem/physiol Actions

CP-809,101 is a potent and high-affinity 5-hydroxytryptamine receptor 2C (5-HT2C) full agonist with only weaker partial agonist activity toward 5-HT2A & 5-HT2B (cellular Ca2+ mobilization EC50 in nM/efficiency = 0.11/93% and 0.06/97% with human and rat 5-HT2C, respectively; 153/67%/human 5HT2A, 65.3/57%/human 5HT2B, 119/79%/rat 5HT2A) and much reduced or little affinity toward other receptors, ion channels and uptake sites tested. CP-809,101 exhibits antipsychotic efficacy in reducing conditioned avoidance response/CAR (ED50 = 4.8 mg/kg s.c.) and locomotor activity (ED50 in mg/kg via s.c. = 2/rats, 1/mice; no effect up to 10 mg/kg in 5-HT2C-knockout mice), while oral administration is reported to suppress spontaneous and nocturnal food intake as well as fasting-induced refeeding in rats (～8% and ～24% reduction of cumulative food intake and body weight in 4 days, respectively; 30 mg/kg/day p.o.).

2-[(3-CHLOROPHENYL)METHOXY]-6-(1-PIPERAZINYL)PYRAZINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-[(3-CHLOROPHENYL)METHOXY]-6-(1-PIPERAZINYL)PYRAZINE HYDROCHLORIDE Suppliers

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479683-64-2, 2-[(3-CHLOROPHENYL)METHOXY]-6-(1-PIPERAZINYL)PYRAZINE HYDROCHLORIDERelated Search:

2-[(3-CHLOROPHENYL)METHOXY]-6-(1-PIPERAZINYL)PYRAZINE HYDROCHLORIDE 6-(BENZYLOXY)PYRAZIN-2-AMINE 6-Methoxypyrazinamine

  • 2-[(3-CHLOROPHENYL)METHOXY]-6-(1-PIPERAZINYL)PYRAZINE HYDROCHLORIDE
  • CP 809101 HYDROCHLORIDE
  • CP 809101
  • CP809101
  • CP-809101
  • 6'-(3-Chlorobenzyloxy)-3,4,5,6-tetrahydro-2H-[1,2']bipyrazine
  • CP809101/CP-809101
  • CS-687
  • Pyrazine, 2-[(3-chlorophenyl)methoxy]-6-(1-piperazinyl)-
  • CP 809101 hydrochlor
  • CP-809102 hydrochloride
  • 479683-64-2
  • C15H17N4OClHCl
  • Potent and selective 5-HT2C receptor agonist