ChemicalBook > CAS DataBase List > 2,3-BIS(BROMOMETHYL)QUINOXALINE 1,4-DIOXIDE

2,3-BIS(BROMOMETHYL)QUINOXALINE 1,4-DIOXIDE

Product Name: 2,3-BIS(BROMOMETHYL)QUINOXALINE 1,4-DIOXIDE
CAS No.: 18080-67-6
Chemical Name: 2,3-BIS(BROMOMETHYL)QUINOXALINE 1,4-DIOXIDE
Synonyms: Conoidin A;Conoidin A, 10 mM in DMSO;Peroxiredoxin Inhibitor, Conoidin A;2,3-BIS(BROMOMETHYL)QUINOXALINE 1,4-DIOXIDE;Quinoxaline, 2,3-bis(bromomethyl)-, 1,4-dioxide;2,3-bis(broMoMethyl)-1-oxoquinoxalin-1-iuM-4(1H)-olate;antioxidative,antioxidant,heart disease,Parasite,Inhibitor,Peroxiredoxin II,hyperperoxidation,Conoidin A,ischaemic,inhibit,neuroprotective
CBNumber: CB72455090
Molecular Formula: C10H8Br2N2O2
Formula Weight: 347.99
MOL File: 18080-67-6.mol

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2,3-BIS(BROMOMETHYL)QUINOXALINE 1,4-DIOXIDE Property

Melting point:: 180-190 °C (decomp)
Boiling point:: 512.3±60.0 °C(Predicted)
Density: 1.95±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMF: 25 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 20 mg/ml
form: A crystalline solid
pka: 1.91±0.30(Predicted)
color: White to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 5.30746
Product name: Peroxiredoxin Inhibitor, Conoidin A - CAS 18080-67-6 - Calbiochem
Packaging: 25mg
Price: $271
Updated: 2025/07/31

Cayman Chemical

Product number: 15605
Product name: Conoidin A
Purity: ≥98%
Packaging: 25mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 15605
Product name: Conoidin A
Purity: ≥98%
Packaging: 50mg
Price: $85
Updated: 2024/03/01

Cayman Chemical

Product number: 15605
Product name: Conoidin A
Purity: ≥98%
Packaging: 100mg
Price: $111
Updated: 2024/03/01

Cayman Chemical

Product number: 15605
Product name: Conoidin A
Purity: ≥98%
Packaging: 250mg
Price: $249
Updated: 2024/03/01

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2,3-BIS(BROMOMETHYL)QUINOXALINE 1,4-DIOXIDE Chemical Properties,Usage,Production

Uses

Conoidin A is a peroxiredoxin inhibitor.

Biological Activity

Cell permeable: yes', 'Primary Target
Peroxiredoxin', 'Reversible: no', 'Target IC50: 23 μM for blocking TgPrxII hyperperoxidation activity

in vivo

Conoidin A (intraperitoneal injection; 5 mg/kg; for three successive days before MI/R injury) blocks the effect of Luteolin (HY-N0162) on the ST-segment elevation. Furthermore, an increase in the infarct size presented of the MI/R group can be reduced by Luteolin. But pre-treatment with conoidin A abolishs the effect of Luteolin. Pre-treatment with conoidin A also prevents Luteolin-reduced activities of CK-MB, AST and LDH in vivo^[3].

Animal Model:	Rat myocardial I/R model^[3]
Dosage:	5?mg/kg
Administration:	Intraperitoneal injection; 5?mg/kg; for three successive days before MI/R injury
Result:	Significantly reversed the antioxidative effect of Luteolin. Impaired the protective effects of luteolin.

IC 50

Toxoplasma

2,3-BIS(BROMOMETHYL)QUINOXALINE 1,4-DIOXIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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18080-67-6, 2,3-BIS(BROMOMETHYL)QUINOXALINE 1,4-DIOXIDERelated Search:

2-bromo-4-methylpropiophenone 2-METHYL-1,3-PROPANEDIOL dimethylsilanediol 2,3-BIS(BROMOMETHYL)QUINOXALINE 1,4-DIOXIDE PYRAZINE-N,N'-DIOXIDE PYRAZINE N-OXIDE quindoxin 2,3-BIS(BROMOMETHYL)QUINOXALINE 2-(BROMOMETHYL)-3-METHYLQUINOXALINE QUINOXALINE N-OXIDE 2,3-dimethylquinoxaline 1,4-dioxide 2-METHYLQUINOXALINEDIIUM-1,4-DIOLATE Pyrazine, (bromomethyl)- (9CI)

2,3-BIS(BROMOMETHYL)QUINOXALINE 1,4-DIOXIDE

2,3-bis(broMoMethyl)-1-oxoquinoxalin-1-iuM-4(1H)-olate

Conoidin A

Quinoxaline, 2,3-bis(bromomethyl)-, 1,4-dioxide

antioxidative,antioxidant,heart disease,Parasite,Inhibitor,Peroxiredoxin II,hyperperoxidation,Conoidin A,ischaemic,inhibit,neuroprotective

Conoidin A, 10 mM in DMSO

Peroxiredoxin Inhibitor, Conoidin A

18080-67-6

C10H8Br2N2O2