ChemicalBook > CAS DataBase List > 5-(2-PYRIDYL)-1,2-DIHYDROPYRIDIN-2-ONE

5-(2-PYRIDYL)-1,2-DIHYDROPYRIDIN-2-ONE

Product Name
5-(2-PYRIDYL)-1,2-DIHYDROPYRIDIN-2-ONE
CAS No.
381233-78-9
Chemical Name
5-(2-PYRIDYL)-1,2-DIHYDROPYRIDIN-2-ONE
Synonyms
[2,3'-BIPYRIDIN]-6'(1'H)-ONE;3'-bipyridin]-6'-ol;Perampanel Impurity 1;2,3'-bipyridin]-6'-ol;Pyronoprene Impurity 47;5-(2-PYRIDYL)-2-PYRIDONE;Perampanel Intermediate 1;2,3'-Bipyridin]-6'(1'H)-one;5-(2-Pyridyl)pyridin-2(1H)-one;2-Hydroxy-5-(2-pyridyl)pyridine
CBNumber
CB72456451
Molecular Formula
C10H8N2O
Formula Weight
172.18
MOL File
381233-78-9.mol
More
Less

5-(2-PYRIDYL)-1,2-DIHYDROPYRIDIN-2-ONE Property

Melting point:
71-75°C
Boiling point:
434.3±45.0 °C(Predicted)
Density 
1.221±0.06 g/cm3 (20 ºC 760 Torr)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka
10.85±0.10(Predicted)
form 
Solid
color 
White
InChI
InChI=1S/C10H8N2O/c13-10-5-4-8(7-12-10)9-3-1-2-6-11-9/h1-7H,(H,12,13)
InChIKey
NHWKTZWOSIVHOL-UHFFFAOYSA-N
SMILES
C1(C2C=CC(=O)NC=2)=NC=CC=C1
More
Less

Safety

HS Code 
29333990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

TRC
Product number
P991805
Product name
5-(2-Pyridyl)-1,2-dihydropyridin-2-one
Packaging
1g
Price
$180
Updated
2021/12/16
TRC
Product number
P991805
Product name
5-(2-Pyridyl)-1,2-dihydropyridin-2-one
Packaging
2.5g
Price
$325
Updated
2021/12/16
AK Scientific
Product number
4908AB
Product name
[2,3'-Bipyridin]-6'(1'H)-one
Packaging
1g
Price
$188
Updated
2021/12/16
Matrix Scientific
Product number
089188
Product name
5-(Pyridin-2-yl)-1,2-dihydropyridin-2-one
Purity
>97%
Packaging
500mg
Price
$408
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0387658
Product name
[2,3'-BIPYRIDIN]-6'(1'-H)-ONE
Purity
95.00%
Packaging
5MG
Price
$498.76
Updated
2021/12/16
More
Less

5-(2-PYRIDYL)-1,2-DIHYDROPYRIDIN-2-ONE Chemical Properties,Usage,Production

Uses

5-(2-Pyridyl)-1,2-dihydropyridin-2-one is used in the synthesis of AMPA receptor antagonists in the treatment of neurological diseases causing dysfunction of glutamatergic neurotransmission.

Synthesis

109-04-6

1054483-78-1

381233-78-9

The general procedure for the synthesis of [2,3'-bipyridin]-6'(1'H)-ones from 2-bromopyridine and 2-hydroxypyridine-5-boronic acid pinacol ester was carried out as follows: firstly, the synthesis of [2,3'-bipyridin]-6'(1'H)-one was carried out by Suzuki coupling reaction of 2-bromopyridine (18) with 6-hydroxypyridine-3-boronic acid pinacol ester catalyzed by Pd(PPh3)4, with Na2CO3 as the base and CH3CN/H2O ( 1/1) as solvent and reacted at 75 °C to afford intermediate 20 in 70% yield. Subsequently, intermediate 20 was converted to thio analog 21 in 71% yield by reaction with P2S5 in pyridine at 120 °C. Finally, intermediate 21 was alkylated with 2-methylbenzyl bromide in DMF in the presence of K2CO3 to give the target product 22 in 76% yield. This synthetic route is also suitable for the preparation of other analogs for assessing the effect of phenyl and pyridyl substituents on the pyridazine ring.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 19, p. 5774 - 5777
[2] Patent: WO2013/19938, 2013, A1. Location in patent: Page/Page column 34; 35

5-(2-PYRIDYL)-1,2-DIHYDROPYRIDIN-2-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

5-(2-PYRIDYL)-1,2-DIHYDROPYRIDIN-2-ONE Suppliers

China 170 India 8 United Kingdom 2 United States 5 Global 185
Sichuan Lancent Medical Devices Co., Ltd.
Tel
18111675298
Fax
-
Email
stochem@aliyun.com
Country
China
ProdList
212
Advantage
58
Chengdu anman biomedical technology co., LTD
Tel
028-86617873 18113025300
Email
yukijiangli@amanbio.com
Country
China
ProdList
117
Advantage
58
Shanghai YuLue Chemical Co., Ltd.
Tel
021-60345187 13671753212
Fax
021-34702061
Email
lzz841106@aliyun.com
Country
China
ProdList
10263
Advantage
55
Shanghai Witofly Chemical Co. ,Ltd.
Tel
021-50630626 18964684208
Email
sales@witofly.com
Country
China
ProdList
1606
Advantage
55
Chengdu Miracle Pharmaceutical Co., Ltd.
Tel
028-86136736 19130631884
Fax
028-85265615
Email
sales@mic-pharma.com
Country
China
ProdList
337
Advantage
56
Chengdu Dorher Pharmaceutical CO.,Ltd
Tel
028-64259743; 19983537320
Email
bd-focus@focuspharm.com
Country
China
ProdList
682
Advantage
58
NANJING WEDO PHARMATECH CO.,LTD.
Tel
15189836218
Email
wedo-chem@huawe.com
Country
China
ProdList
276
Advantage
58
LEWOO PHARMATECH (SHANGHAI) CO.,LTD
Tel
15800805830
Fax
021 67898603
Email
miao@lewoopharma.com.cn
Country
China
ProdList
932
Advantage
58
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
16077
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
Shanghai Waytry Pharmas Co. Ltd.
Tel
021-50728690 18101878792
Fax
+86-21-50728690
Email
sales@waytrypharms.com
Country
China
ProdList
49
Advantage
57
ZhengZhou HuaWen Chemical Co.Ltd
Tel
0370-2785118 17550508557
Fax
QQ：3470079902
Email
675141927@qq.com
Country
China
ProdList
3199
Advantage
55
T&W GROUP
Tel
021-61551611 13296011611
Fax
＋86 21-50676805
Email
contact@trustwe.com
Country
China
ProdList
9895
Advantage
58
Chengdu Forest Science and Technology Development Co., Ltd.
Tel
18030648795
Fax
028-61777050
Email
sales@cdforestchem.com
Country
China
ProdList
2000
Advantage
58
Shanghai MOF Chemical Tech Limited
Tel
13661494087 18964793018
Fax
86-021-51821718 QQ：2427604606
Email
sales@mof-chemicals.com
Country
China
ProdList
293
Advantage
55
Shanghai Hao Yun Chemical Science Co.,Ltd.
Tel
021-68367562 15002147577;
Fax
021-68369562
Email
sales@haoyunchem.com
Country
China
ProdList
457
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
Shanghai Aspire Biological Technology Co., Ltd.
Tel
021-61317773/021-31606483/2934163037
Fax
021-61317773-604
Email
sales@aspirebio.com
Country
China
ProdList
257
Advantage
58
Suzhou yacoo science co.,Ltd
Tel
0512-87182056 18013166090
Fax
0512-87182056
Email
lingling.qi@yacoo.com.cn
Country
China
ProdList
6295
Advantage
60
Chengdu Laurelsci Tech Co., Ltd.
Tel
028-87983001
Fax
+86-28-86102331
Email
sales@laurelsci.com
Country
China
ProdList
50
Advantage
58
Shanghai Kewel Chemical Co., Ltd.
Tel
021-64609169 18901607656
Fax
021-64609160
Email
greensnown@163.com
Country
China
ProdList
9906
Advantage
50
Hangzhou J&H Chemical Co., Ltd.
Tel
0571-87396432
Fax
0571-87396431
Email
sales@jhechem.com
Country
China
ProdList
14912
Advantage
59
LUCKY PHARMA CO., LIMITED
Tel
0571-86403260 86403970
Fax
0571-86403970
Email
lucky@lkbiology.com
Country
China
ProdList
243
Advantage
58
Credit Asia Chemical Co., Ltd.
Tel
+86 (21) 61124340
Fax
+86 (21) 6129-4103
Country
China
ProdList
9756
Advantage
58
BEIJING EAGLE SKY PHARMATECH CO., LTD
Tel
010-88755821 13911359480
Email
sophia_818@126.com
Country
China
ProdList
294
Advantage
55
Sichuan Argalbio Technology Co,.Ltd
Tel
028-028-60651388 13330964498
Email
slyu@hengkangtech.com
Country
China
ProdList
378
Advantage
58
Chizhou Kailong Import and Export Trade Co., Ltd.
Tel
Fax
-
Email
xg01_gj@163.com
Country
China
ProdList
9484
Advantage
50
Guangzhou Ciming Biological Technology Co., Ltd.
Tel
020-38082199,29065168,38082986,29878298,29866629,4000192398
Fax
+86 (20)38082986
Country
China
ProdList
830
Advantage
60
Struchem Co., Ltd.
Tel
0512-63009836 18994340901
Fax
0512-63006936
Email
helen@struchem.com
Country
China
ProdList
3981
Advantage
60
Shanghai Haozhixiang Biotechnology Co., Ltd
Tel
526763801 13301653310
Fax
+86-21-51619052
Email
526763801@qq.com
Country
China
ProdList
9287
Advantage
55
Shanghai Qiao Chemical Science Co., Ltd
Tel
021-58892003
Email
info@qiaochem.com
Country
China
ProdList
6059
Advantage
65
Shanghai Toplab Chemical Co., Ltd.
Tel
021-31137757-00; 18121466954
Fax
021-64902762
Email
28328681@qq.com
Country
China
ProdList
180
Advantage
55
Shanghai Changyan Chem & Tech Co., Ltd.
Tel
021-20242659 18930833303
Fax
+86 (21) 2024-2659
Email
Sales@changyanchem.cn
Country
China
ProdList
5001
Advantage
55
Changzhou PBpharmaceutical R&D Co.,Ltd
Tel
086-0519-83990708 18915800124
Fax
0519-83990708
Email
info@pbpharm.com
Country
China
ProdList
487
Advantage
55
Cangzhou Enke Pharma-tech Co., Ltd.
Tel
0317-5296180 15533709196
Fax
0317-5106596
Email
sale@enkepharma.com
Country
China
ProdList
2267
Advantage
55
Grader reagent
Tel
18221735425
Email
sales@xinpingchem.com
Country
China
ProdList
9942
Advantage
58
Changzhou Union Chemicals Co.,Ltd.
Tel
0519-86802352
Fax
0519 86396223
Email
info@union-chems.com
Country
China
ProdList
485
Advantage
58
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9125
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
JINAN SHENGQI PHARMACEUTICAL CO., LTD
Tel
0531-0531-88892685 18660160628
Email
15069007290@163.com
Country
China
ProdList
154
Advantage
58
Shanghai Kangman Biological Technology Co., Ltd.
Tel
18800375331
Fax
021-50908862
Email
kangmansales@163.com
Country
China
ProdList
7570
Advantage
55
Henan Anky Chemical Technology Co., Ltd.
Tel
17836913271
Fax
0374-8348899
Email
3224305243@qq.com
Country
China
ProdList
2952
Advantage
58
Chengdu Aminotp Pharmaceutical Technology Co.,Ltd.
Tel
028-85755578 18140172005
Fax
028-85755578
Email
sales@aminotp.com
Country
China
ProdList
298
Advantage
58
Combiphos (Shanghai) Biological Technology Co., Ltd.
Tel
021-65232103 17602124823
Email
combiphos@vip.qq.com
Country
China
ProdList
30000
Advantage
58
Wuxi AppTec
Tel
022-59987777 13552403979
Email
jia_guoqiang@wuxiapptec.com
Country
China
ProdList
22345
Advantage
58
Jinan Daen Pharmaceutical Technology Co., Ltd
Tel
0531-68657833 15553112864
Fax
-
Email
2098511187@qq.com
Country
China
ProdList
295
Advantage
58
Capot Chemical Co.,Ltd.
Tel
+86-（0）57185586718; +8613336195806
Fax
+86-571-85864795
Email
sales@capot.com
Country
China
ProdList
29735
Advantage
60
Aikon International Limited
Tel
025-66061636 18013972705
Fax
(3)02557626880
Email
qqyang@aikonchem.com
Country
China
ProdList
15814
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 400821072
Fax
021-58955996
Email
malulu@leyan.com
Country
China
ProdList
25000
Advantage
58
More
Less

View Lastest Price from 5-(2-PYRIDYL)-1,2-DIHYDROPYRIDIN-2-ONE manufacturers

Shanghai Joiny Pharmaceutical Co.,LTD
Product
5-(2-Pyridyl)-1,2-dihydropyridin-2-one 381233-78-9
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
25kg
Release date
2022-02-17
Henan Fengda Chemical Co., Ltd
Product
5-(2-PYRIDYL)-1,2-DIHYDROPYRIDIN-2-ONE 381233-78-9
Price
US $8.00-2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-24
Hangzhou ICH Biofarm Co., Ltd
Product
5-(2-PYRIDYL)-1,2-DIHYDROPYRIDIN-2-ONE 381233-78-9
Price
US $0.00-0.00/kg
Min. Order
0.1kg
Purity
99.0%min
Supply Ability
200kg
Release date
2023-06-09

381233-78-9, 5-(2-PYRIDYL)-1,2-DIHYDROPYRIDIN-2-ONERelated Search:

4-HYDROXYPYRIDINE 5'-broMo-1'-phenyl-[2,3'-bipyridin]-6'(1'H)-one 2-(1,3,2-DIOXABOROLAN-2-YL)BENZONITRILE 5-Bromo-2-methoxypyridine 2,5-Dibromopyridine 2-(2-cyanophenyl)benzonitrile 2-Bromobenzonitrile 1-Phenyl-5-(pyridin-2-yl)-1,2-dihydropyridin-2-one 3,5-Dimethoxypyridine Phenylboronic acid 2-Cyanophenylboronic acid PeraMpanel 3,5-Dibromopyridine 6'-Methoxy-2,3'-bipyridine PeraMpanel PRMWGUBFXWROHD-MYWHSQMISA-N 5'-(2-cyanophenyl)-6'-oxo-1'-phenyl-1',6'-dihydro-[2,3'-bipyridine] 1-oxide 4-(6'-oxo-1'-phenyl-1',6'-dihydro-[2,3'-bipyridin]-5'-yl)benzonitrile

  • [2,3'-BIPYRIDIN]-6'(1'H)-ONE
  • 5-(2-PYRIDYL)-1,2-DIHYDROPYRIDIN-2-ONE
  • 5-(Pyridin-2-yl)-2(1H)-pyridone
  • 5-(Pyridin-2-yl)-1,2-dihydropyridin-2-one
  • 5-(Pyridin-2-yl)pyridin-2(1H)-one
  • 5-(2-Pyridyl)pyridin-2(1H)-one
  • 5-pyridin-2-yl-1H-pyridin-2-one
  • 5-(2-PYRIDYL)-2-PYRIDONE
  • 2-Hydroxy-5-(2-pyridyl)pyridine
  • 5-(2-pyridyl)-1,2-dihydropyridine-2-one
  • Perampanel Impurity 1
  • 3'-bipyridin]-6'-ol
  • 2,3'-bipyridin]-6'-ol
  • Perampanel Intermediate 1
  • 2,3'-Bipyridin]-6'(1'H)-one (9CI, ACI)
  • 2,3'-Bipyridin]-6'(1'H)-one
  • Pyronoprene Impurity 47
  • 381233-78-9
  • API