5-(4-Methylpiperazin-1-yl)pyridin-2-amine

Product Name: 5-(4-Methylpiperazin-1-yl)pyridin-2-amine
CAS No.: 571189-49-6
Chemical Name: 5-(4-Methylpiperazin-1-yl)pyridin-2-amine
Synonyms: -4-(6-aminopyridin-3-yL;5-(4-Methylpiperazin-1-yl);2-Fluoro-47-(methylthio)pyridine;5-(4-Methyl-1-piperazinyl)-2-pyridinamine;5-(4-methylpiperazin-1-yl)pyridin-2-amine;1-METHYL-4-(6-AMINOPYRIDIN-3-YL)PIPERAZINE;2-Amino-5-(N-methylpiperazin-1-yl)pyridine;2-Amino-5-(4-methyl-1-piperazinyl)pyridine;2-PyridinaMine, 5-(4-Methyl-1-piperazinyl)-;5-(4-Methyl-piperazin-1-yl)-pyridin-2-ylamine
CBNumber: CB72458778
Molecular Formula: C10H16N4
Formula Weight: 192.26
MOL File: 571189-49-6.mol

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5-(4-Methylpiperazin-1-yl)pyridin-2-amine Property

Melting point:: 148 °C
Boiling point:: 368.1±42.0 °C(Predicted)
Density: 1.142±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: Acetonitrile (Slightly), Chloroform (Slightly), Water (Slightly)
form: powder to crystal
pka: 7.41±0.42(Predicted)
color: Light yellow to Brown
Stability:: Hygroscopic
InChI: InChI=1S/C10H16N4/c1-13-4-6-14(7-5-13)9-2-3-10(11)12-8-9/h2-3,8H,4-7H2,1H3,(H2,11,12)
InChIKey: QDMPMBFLXOWHRY-UHFFFAOYSA-N
SMILES: C1(N)=NC=C(N2CCN(C)CC2)C=C1

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Safety

Hazard Codes: Xn
Risk Statements: 22
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical

Product number: M3176
Product name: 5-(4-Methylpiperazin-1-yl)pyridin-2-amine
Packaging: 1G
Price: $69
Updated: 2026/04/30

TCI Chemical

Product number: M3176
Product name: 5-(4-Methylpiperazin-1-yl)pyridin-2-amine
Packaging: 5G
Price: $273
Updated: 2026/04/30

TRC

Product number: M320895
Product name: 5-(4-Methylpiperazin-1-yl)pyridin-2-amine
Packaging: 500mg
Price: $65
Updated: 2021/12/16

TRC

Product number: M320895
Product name: 5-(4-Methylpiperazin-1-yl)pyridin-2-amine
Packaging: 5g
Price: $130
Updated: 2021/12/16

AK Scientific

Product number: W7065
Product name: 1-Methyl-4-(6-aminopyridin-3-yl)piperazine
Packaging: 5g
Price: $134
Updated: 2021/12/16

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5-(4-Methylpiperazin-1-yl)pyridin-2-amine Chemical Properties,Usage,Production

Description

5-(4-Methylpiperazin-1-yl)pyridin-2-amine is a pharmaceutical intermediate compound that can be used to prepare trilaciclib. Trilaciclib is the first intravenous CDK4/6 inhibitor approved by the FDA for reducing the risk of bone marrow suppression (i.e. decreased red blood cells, white blood cells, and platelets) in adult patients with small cell lung cancer (SCLC) caused by specific chemotherapy drugs.

Chemical Properties

Light yellow to Brown powder to crystal.

Uses

5-(4-Methylpiperazin-1-yl)pyridin-2-amine can be used for chemical mechanical planarization for tungsten-containing substrates.

Synthesis

657410-79-2

571189-49-6

General procedure for the synthesis of 1-methyl-4-(6-aminopyridin-3-yl)piperazine from 1-methyl-4-(6-nitropyridin-3-yl)piperazine: a mixture of 1-methyl-4-(6-nitropyridin-3-yl)piperazine (1.11 g, 5.02 mmol) and 10% Pd/C (110 mg) in methanol (15 mL) was stirred for 5 h at room temperature . Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated to afford 951 mg (99% yield) of a yellow solid product, 1-methyl-4-(6-aminopyridin-3-yl)piperazine, which could be used in the subsequent reaction without further purification. The 1H NMR (CDCl3) data of the product were as follows: δ 7.78 (d, 1H, J = 3.0 Hz), 7.18 (dd, 1H, J = 3.0, 8.9 Hz), 6.48 (d, 1H, J = 8.9 Hz), 3.08 (dd, 4H, J = 4.9, 4.9 Hz), 2.61 (dd, 4H, J = 4.9, 4.9 Hz) , 2.37 (s, 3H).

References

[1] Journal of Medicinal Chemistry, 2017, vol. 60, # 5, p. 1892 - 1915
[2] Patent: US2005/38078, 2005, A1. Location in patent: Page/Page column 29
[3] Patent: WO2004/14904, 2004, A1. Location in patent: Page 51
[4] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 2, p. 348 - 364
[5] Patent: US2017/313683, 2017, A1. Location in patent: Paragraph 0300-0301

5-(4-Methylpiperazin-1-yl)pyridin-2-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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5-(4-Methylpiperazin-1-yl)pyridin-2-amine Suppliers

Americas 1 China 197 Europe 1 India 9 Japan 1 United Kingdom 1 United States 8 Global 218

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View Lastest Price from 5-(4-Methylpiperazin-1-yl)pyridin-2-amine manufacturers

Jinan Ruitong Biotech Co., Ltd.

Product: 5-(4-Methylpiperazin-1-yl)pyridin-2-amine 571189-49-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1
Release date: 2025-08-29

Shaanxi Dideu Medichem Co. Ltd

Product: 1-METHYL-4-(6-AMINOPYRIDIN-3-YL)PIPERAZINE 571189-49-6
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-25

Zibo Hangyu Biotechnology Development Co., Ltd

Product: 1-METHYL-4-(6-AMINOPYRIDIN-3-YL)PIPERAZINE 571189-49-6
Price: US $70.00-550.00/g
Min. Order: 5g
Purity: 99%
Supply Ability: 50
Release date: 2024-07-11

571189-49-6, 5-(4-Methylpiperazin-1-yl)pyridin-2-amineRelated Search:

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1-METHYL-4-(6-AMINOPYRIDIN-3-YL)PIPERAZINE

5-(4-Methyl-piperazin-1-yl)-pyridin-2-ylamine

5-(4-Methylpiperazin-1-yl)

2-PyridinaMine, 5-(4-Methyl-1-piperazinyl)-

2-Amino-5-(4-methyl-1-piperazinyl)pyridine

2-Amino-5-(N-methylpiperazin-1-yl)pyridine

-4-(6-aminopyridin-3-yL

5-(4-Methyl-1-piperazinyl)-2-pyridinamine

1-METHYL-4-(6-AMINOPYRIDIN-3-YL)PIPERAZINE ISO 9001：2015 REACH

tert-butyl 3-allyl-3-hydroxyazetidine-17-carboxylate

2-Fluoro-47-(methylthio)pyridine

1-Methyl-4-(6-Aminopyridin-3-Yl)Piperazine(WX609129)

5-(4-methylpiperazin-1-yl)pyridin-2-amine

571189-49-6