1-METHYL-4-(6-AMINOPYRIDIN-3-YL)PIPERAZINE

Product Name: 1-METHYL-4-(6-AMINOPYRIDIN-3-YL)PIPERAZINE
CAS No.: 571189-49-6
Chemical Name: 1-METHYL-4-(6-AMINOPYRIDIN-3-YL)PIPERAZINE
Synonyms: -4-(6-aminopyridin-3-yL;5-(4-Methylpiperazin-1-yl);2-Fluoro-47-(methylthio)pyridine;5-(4-Methyl-1-piperazinyl)-2-pyridinamine;1-METHYL-4-(6-AMINOPYRIDIN-3-YL)PIPERAZINE;2-Amino-5-(N-methylpiperazin-1-yl)pyridine;2-Amino-5-(4-methyl-1-piperazinyl)pyridine;2-PyridinaMine, 5-(4-Methyl-1-piperazinyl)-;5-(4-Methyl-piperazin-1-yl)-pyridin-2-ylamine;tert-butyl 3-allyl-3-hydroxyazetidine-17-carboxylate
CBNumber: CB72458778
Molecular Formula: C10H16N4
Formula Weight: 192.26
MOL File: 571189-49-6.mol

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1-METHYL-4-(6-AMINOPYRIDIN-3-YL)PIPERAZINE Property

Melting point:: 148 °C
Boiling point:: 368.1±42.0 °C(Predicted)
Density: 1.142±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: Acetonitrile (Slightly), Chloroform (Slightly), Water (Slightly)
form: powder to crystal
pka: 7.41±0.42(Predicted)
color: Light yellow to Brown
Stability:: Hygroscopic
InChI: InChI=1S/C10H16N4/c1-13-4-6-14(7-5-13)9-2-3-10(11)12-8-9/h2-3,8H,4-7H2,1H3,(H2,11,12)
InChIKey: QDMPMBFLXOWHRY-UHFFFAOYSA-N
SMILES: C1(N)=NC=C(N2CCN(C)CC2)C=C1

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Safety

Hazard Codes: Xn
Risk Statements: 22
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical

Product number: M3176
Product name: 5-(4-Methylpiperazin-1-yl)pyridin-2-amine
Packaging: 1G
Price: $66
Updated: 2025/07/31

TCI Chemical

Product number: M3176
Product name: 5-(4-Methylpiperazin-1-yl)pyridin-2-amine
Packaging: 5G
Price: $262
Updated: 2025/07/31

TRC

Product number: M320895
Product name: 5-(4-Methylpiperazin-1-yl)pyridin-2-amine
Packaging: 500mg
Price: $65
Updated: 2021/12/16

TRC

Product number: M320895
Product name: 5-(4-Methylpiperazin-1-yl)pyridin-2-amine
Packaging: 5g
Price: $130
Updated: 2021/12/16

AK Scientific

Product number: W7065
Product name: 1-Methyl-4-(6-aminopyridin-3-yl)piperazine
Packaging: 5g
Price: $134
Updated: 2021/12/16

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1-METHYL-4-(6-AMINOPYRIDIN-3-YL)PIPERAZINE Chemical Properties,Usage,Production

Chemical Properties

Light yellow to Brown powder to crystal.

Uses

5-(4-Methylpiperazin-1-yl)pyridin-2-amine can be used for chemical mechanical planarization for tungsten-containing substrates.

Synthesis

657410-79-2

571189-49-6

General procedure for the synthesis of 1-methyl-4-(6-aminopyridin-3-yl)piperazine from 1-methyl-4-(6-nitropyridin-3-yl)piperazine: a mixture of 1-methyl-4-(6-nitropyridin-3-yl)piperazine (1.11 g, 5.02 mmol) and 10% Pd/C (110 mg) in methanol (15 mL) was stirred for 5 h at room temperature . Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated to afford 951 mg (99% yield) of a yellow solid product, 1-methyl-4-(6-aminopyridin-3-yl)piperazine, which could be used in the subsequent reaction without further purification. The 1H NMR (CDCl3) data of the product were as follows: δ 7.78 (d, 1H, J = 3.0 Hz), 7.18 (dd, 1H, J = 3.0, 8.9 Hz), 6.48 (d, 1H, J = 8.9 Hz), 3.08 (dd, 4H, J = 4.9, 4.9 Hz), 2.61 (dd, 4H, J = 4.9, 4.9 Hz) , 2.37 (s, 3H).

References

[1] Journal of Medicinal Chemistry, 2017, vol. 60, # 5, p. 1892 - 1915
[2] Patent: US2005/38078, 2005, A1. Location in patent: Page/Page column 29
[3] Patent: WO2004/14904, 2004, A1. Location in patent: Page 51
[4] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 2, p. 348 - 364
[5] Patent: US2017/313683, 2017, A1. Location in patent: Paragraph 0300-0301

1-METHYL-4-(6-AMINOPYRIDIN-3-YL)PIPERAZINE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-METHYL-4-(6-AMINOPYRIDIN-3-YL)PIPERAZINE Suppliers

Americas 1 China 197 Europe 1 India 8 Japan 1 United Kingdom 1 United States 8 Global 217

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View Lastest Price from 1-METHYL-4-(6-AMINOPYRIDIN-3-YL)PIPERAZINE manufacturers

Jinan Ruitong Biotech Co., Ltd.

Product: 5-(4-Methylpiperazin-1-yl)pyridin-2-amine 571189-49-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1
Release date: 2025-08-29

Shaanxi Dideu Medichem Co. Ltd

Product: 1-METHYL-4-(6-AMINOPYRIDIN-3-YL)PIPERAZINE 571189-49-6
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-25

Zibo Hangyu Biotechnology Development Co., Ltd

Product: 1-METHYL-4-(6-AMINOPYRIDIN-3-YL)PIPERAZINE 571189-49-6
Price: US $70.00-550.00/g
Min. Order: 5g
Purity: 99%
Supply Ability: 50
Release date: 2024-07-11

571189-49-6, 1-METHYL-4-(6-AMINOPYRIDIN-3-YL)PIPERAZINERelated Search:

5-(4-ethylpiperazin-1-yl)pyridin-2-amine 5-[4-(1,3-thiazol-2-yl)piperazin-1-yl]pyridin-2-amine 4-[6-(6-BROMO-8-CYCLOPENTYL-5-METHYL-7-OXO-7,8-DIHYDRO-PYRIDO[2,3-D]PYRIMIDIN-2-YLAMINO)-PYRIDIN-3-YL]-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER OTAVA-BB 1119890 OTAVA-BB 1119887 1-[4-(6-aminopyridin-3-yl)piperazin-1-yl]ethan-1-one OTAVA-BB 1119894 5-(4-propylpiperazin-1-yl)pyridin-2-amine ethyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate 1-METHYL-4-(6-AMINOPYRIDIN-3-YL)PIPERAZINE

1-METHYL-4-(6-AMINOPYRIDIN-3-YL)PIPERAZINE

5-(4-Methyl-piperazin-1-yl)-pyridin-2-ylamine

5-(4-Methylpiperazin-1-yl)

2-PyridinaMine, 5-(4-Methyl-1-piperazinyl)-

2-Amino-5-(4-methyl-1-piperazinyl)pyridine

2-Amino-5-(N-methylpiperazin-1-yl)pyridine

-4-(6-aminopyridin-3-yL

5-(4-Methyl-1-piperazinyl)-2-pyridinamine

1-METHYL-4-(6-AMINOPYRIDIN-3-YL)PIPERAZINE ISO 9001：2015 REACH

tert-butyl 3-allyl-3-hydroxyazetidine-17-carboxylate

2-Fluoro-47-(methylthio)pyridine

1-Methyl-4-(6-Aminopyridin-3-Yl)Piperazine(WX609129)

571189-49-6