ChemicalBook > CAS DataBase List > 1-METHYL-4-(6-AMINOPYRIDIN-3-YL)PIPERAZINE

1-METHYL-4-(6-AMINOPYRIDIN-3-YL)PIPERAZINE

Product Name
1-METHYL-4-(6-AMINOPYRIDIN-3-YL)PIPERAZINE
CAS No.
571189-49-6
Chemical Name
1-METHYL-4-(6-AMINOPYRIDIN-3-YL)PIPERAZINE
Synonyms
-4-(6-aminopyridin-3-yL;5-(4-Methylpiperazin-1-yl);2-Fluoro-47-(methylthio)pyridine;5-(4-Methyl-1-piperazinyl)-2-pyridinamine;1-METHYL-4-(6-AMINOPYRIDIN-3-YL)PIPERAZINE;2-Amino-5-(N-methylpiperazin-1-yl)pyridine;2-Amino-5-(4-methyl-1-piperazinyl)pyridine;2-PyridinaMine, 5-(4-Methyl-1-piperazinyl)-;5-(4-Methyl-piperazin-1-yl)-pyridin-2-ylamine;tert-butyl 3-allyl-3-hydroxyazetidine-17-carboxylate
CBNumber
CB72458778
Molecular Formula
C10H16N4
Formula Weight
192.26
MOL File
571189-49-6.mol
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1-METHYL-4-(6-AMINOPYRIDIN-3-YL)PIPERAZINE Property

Melting point:
148 °C
Boiling point:
368.1±42.0 °C(Predicted)
Density 
1.142±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
Acetonitrile (Slightly), Chloroform (Slightly), Water (Slightly)
form 
powder to crystal
pka
7.41±0.42(Predicted)
color 
Light yellow to Brown
Stability:
Hygroscopic
InChI
InChI=1S/C10H16N4/c1-13-4-6-14(7-5-13)9-2-3-10(11)12-8-9/h2-3,8H,4-7H2,1H3,(H2,11,12)
InChIKey
QDMPMBFLXOWHRY-UHFFFAOYSA-N
SMILES
C1(N)=NC=C(N2CCN(C)CC2)C=C1
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Safety

Hazard Codes 
Xn
Risk Statements 
22
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical
Product number
M3176
Product name
5-(4-Methylpiperazin-1-yl)pyridin-2-amine
Packaging
1G
Price
$66
Updated
2025/07/31
TCI Chemical
Product number
M3176
Product name
5-(4-Methylpiperazin-1-yl)pyridin-2-amine
Packaging
5G
Price
$262
Updated
2025/07/31
TRC
Product number
M320895
Product name
5-(4-Methylpiperazin-1-yl)pyridin-2-amine
Packaging
500mg
Price
$65
Updated
2021/12/16
TRC
Product number
M320895
Product name
5-(4-Methylpiperazin-1-yl)pyridin-2-amine
Packaging
5g
Price
$130
Updated
2021/12/16
AK Scientific
Product number
W7065
Product name
1-Methyl-4-(6-aminopyridin-3-yl)piperazine
Packaging
5g
Price
$134
Updated
2021/12/16
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1-METHYL-4-(6-AMINOPYRIDIN-3-YL)PIPERAZINE Chemical Properties,Usage,Production

Chemical Properties

Light yellow to Brown powder to crystal.

Uses

5-(4-Methylpiperazin-1-yl)pyridin-2-amine can be used for chemical mechanical planarization for tungsten-containing substrates.

Synthesis

657410-79-2

571189-49-6

General procedure for the synthesis of 1-methyl-4-(6-aminopyridin-3-yl)piperazine from 1-methyl-4-(6-nitropyridin-3-yl)piperazine: a mixture of 1-methyl-4-(6-nitropyridin-3-yl)piperazine (1.11 g, 5.02 mmol) and 10% Pd/C (110 mg) in methanol (15 mL) was stirred for 5 h at room temperature . Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated to afford 951 mg (99% yield) of a yellow solid product, 1-methyl-4-(6-aminopyridin-3-yl)piperazine, which could be used in the subsequent reaction without further purification. The 1H NMR (CDCl3) data of the product were as follows: δ 7.78 (d, 1H, J = 3.0 Hz), 7.18 (dd, 1H, J = 3.0, 8.9 Hz), 6.48 (d, 1H, J = 8.9 Hz), 3.08 (dd, 4H, J = 4.9, 4.9 Hz), 2.61 (dd, 4H, J = 4.9, 4.9 Hz) , 2.37 (s, 3H).

References

[1] Journal of Medicinal Chemistry, 2017, vol. 60, # 5, p. 1892 - 1915
[2] Patent: US2005/38078, 2005, A1. Location in patent: Page/Page column 29
[3] Patent: WO2004/14904, 2004, A1. Location in patent: Page 51
[4] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 2, p. 348 - 364
[5] Patent: US2017/313683, 2017, A1. Location in patent: Paragraph 0300-0301

1-METHYL-4-(6-AMINOPYRIDIN-3-YL)PIPERAZINE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-METHYL-4-(6-AMINOPYRIDIN-3-YL)PIPERAZINE Suppliers

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View Lastest Price from 1-METHYL-4-(6-AMINOPYRIDIN-3-YL)PIPERAZINE manufacturers

Jinan Ruitong Biotech Co., Ltd.
Product
5-(4-Methylpiperazin-1-yl)pyridin-2-amine 571189-49-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1
Release date
2025-08-29
Shaanxi Dideu Medichem Co. Ltd
Product
1-METHYL-4-(6-AMINOPYRIDIN-3-YL)PIPERAZINE 571189-49-6
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-25
Zibo Hangyu Biotechnology Development Co., Ltd
Product
1-METHYL-4-(6-AMINOPYRIDIN-3-YL)PIPERAZINE 571189-49-6
Price
US $70.00-550.00/g
Min. Order
5g
Purity
99%
Supply Ability
50
Release date
2024-07-11

571189-49-6, 1-METHYL-4-(6-AMINOPYRIDIN-3-YL)PIPERAZINERelated Search:

5-(4-ethylpiperazin-1-yl)pyridin-2-amine 5-[4-(1,3-thiazol-2-yl)piperazin-1-yl]pyridin-2-amine 4-[6-(6-BROMO-8-CYCLOPENTYL-5-METHYL-7-OXO-7,8-DIHYDRO-PYRIDO[2,3-D]PYRIMIDIN-2-YLAMINO)-PYRIDIN-3-YL]-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER OTAVA-BB 1119890 OTAVA-BB 1119887 1-[4-(6-aminopyridin-3-yl)piperazin-1-yl]ethan-1-one OTAVA-BB 1119894 5-(4-propylpiperazin-1-yl)pyridin-2-amine ethyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate 1-METHYL-4-(6-AMINOPYRIDIN-3-YL)PIPERAZINE

  • 1-METHYL-4-(6-AMINOPYRIDIN-3-YL)PIPERAZINE
  • 5-(4-Methyl-piperazin-1-yl)-pyridin-2-ylamine
  • 5-(4-Methylpiperazin-1-yl)
  • 2-PyridinaMine, 5-(4-Methyl-1-piperazinyl)-
  • 2-Amino-5-(4-methyl-1-piperazinyl)pyridine
  • 2-Amino-5-(N-methylpiperazin-1-yl)pyridine
  • -4-(6-aminopyridin-3-yL
  • 5-(4-Methyl-1-piperazinyl)-2-pyridinamine
  • 1-METHYL-4-(6-AMINOPYRIDIN-3-YL)PIPERAZINE ISO 9001：2015 REACH
  • tert-butyl 3-allyl-3-hydroxyazetidine-17-carboxylate
  • 2-Fluoro-47-(methylthio)pyridine
  • 1-Methyl-4-(6-Aminopyridin-3-Yl)Piperazine(WX609129)
  • 571189-49-6