(1-Methyl-1H-pyrazol-5-yl)-boronic acid

Product Name: (1-Methyl-1H-pyrazol-5-yl)-boronic acid
CAS No.: 720702-41-0
Chemical Name: (1-Methyl-1H-pyrazol-5-yl)-boronic acid
Synonyms: -5-yL;(1-Methyl-1H-pyrazol-5-yl...;1-Methyl-pyrazole-5-boronic acid;(2-methylpyrazol-3-yl)boronic acid;(2-methyl-3-pyrazolyl)boronic acid;1-Methyl-1H-pyrazole-5-boronic acid;1-Methyl-1H-pyrazol-5-yl-5-boronic acid;(1-Methyl-1H-pyrazol-5-yl)-boronic acid;720702-41-0;BORONIC ACID, (1-METHYL-1H-PYRAZOL-5-YL)-
CBNumber: CB72462274
Molecular Formula: C4H7BN2O2
Formula Weight: 125.92
MOL File: 720702-41-0.mol

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(1-Methyl-1H-pyrazol-5-yl)-boronic acid Property

Boiling point:: 323.0±34.0 °C(Predicted)
Density: 1.23±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
pka: 8.00±0.58(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C4H7BN2O2/c1-7-4(5(8)9)2-3-6-7/h2-3,8-9H,1H3
InChIKey: MGNBKNBEZGLHNF-UHFFFAOYSA-N
SMILES: B(C1N(C)N=CC=1)(O)O

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Safety

Risk Statements: 36
Safety Statements: 26
HS Code: 2933199090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: M2680
Product name: (1-Methyl-1H-pyrazol-5-yl)boronic Acid (contains varying amounts of Anhydride)
Packaging: 1G
Price: $56
Updated: 2025/07/31

TCI Chemical

Product number: M2680
Product name: (1-Methyl-1H-pyrazol-5-yl)boronic Acid (contains varying amounts of Anhydride)
Packaging: 5G
Price: $166
Updated: 2025/07/31

TRC

Product number: M321220
Product name: 1-Methyl-1H-pyrazole-5-boronicAcid
Packaging: 5g
Price: $275
Updated: 2021/12/16

Usbiological

Product number: 409996
Product name: 1-Methyl-1H-pyrazole-5-boronic Acid
Packaging: 1g
Price: $347
Updated: 2021/12/16

Oakwood

Product number: 208723
Product name: 1-Methylpyrazole-5-boronicacid
Purity: 97%
Packaging: 250mg
Price: $12
Updated: 2021/12/16

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(1-Methyl-1H-pyrazol-5-yl)-boronic acid Chemical Properties,Usage,Production

Uses

1-Methyl-1H-pyrazole-5-boronic Acid acts as a reagent for the design, synthesis and evaluation of novel porcupine inhibitors featuring a fused 3-ring system based on ‘reversed’ amide scaffold.

Synthesis

930-36-9

720702-41-0

General procedure for the synthesis of 1-methyl-1H-pyrazole-5-boronic acid from 1-methylpyrazole: 1-methylpyrazole (25 mL, 0.3 mol) was dissolved in 500 mL of tetrahydrofuran (THF). The solution was then cooled to -78°C in a dry ice/isopropanol bath. After the solution temperature stabilized at -78 °C, n-butyllithium (n-BuLi, 140 mL, 0.40 mol) was slowly added dropwise through the cannula. After the dropwise addition, the reaction mixture was stirred continuously at -78 °C for 1.5 hours. Next, triisopropyl borate (280 mL, 1.2 mol) was added to the reaction system via cannula and the reaction mixture was allowed to slowly warm from -78 °C to 0 °C while stirring overnight. Upon completion of the reaction, the pH of the mixture was adjusted to 6 with 1 N hydrochloric acid (HCl).Subsequently, THF was evaporated under reduced pressure and the remaining aqueous phase was extracted with ethyl acetate (EtOAc, 2 × 100 mL). Finally, the solid was collected by filtration to afford 108 g (100% yield) of 1-methyl-1H-pyrazole-5-boronic acid as a yellow solid.

References

[1] Patent: WO2005/12254, 2005, A1. Location in patent: Page/Page column 101
[2] Journal of Medicinal Chemistry, 2010, vol. 53, # 5, p. 1923 - 1936
[3] Journal of Heterocyclic Chemistry, 2004, vol. 41, # 6, p. 931 - 939
[4] Patent: WO2004/58722, 2004, A1. Location in patent: Page 63; 62

(1-Methyl-1H-pyrazol-5-yl)-boronic acid Preparation Products And Raw materials

Raw materials

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(1-Methyl-1H-pyrazol-5-yl)-boronic acid Suppliers

China 163 Germany 2 India 1 United Kingdom 1 United States 13 Global 180

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View Lastest Price from (1-Methyl-1H-pyrazol-5-yl)-boronic acid manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: (1-Methyl-1H-pyrazol-5-yl)-boronic acid 720702-41-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: (1-Methyl-1H-pyrazol-5-yl)-boronic acid 720702-41-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

Career Henan Chemical Co

Product: (1-Methyl-1H-pyrazol-5-yl)-boronic acid 720702-41-0
Price: US $500.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2018-08-04

720702-41-0, (1-Methyl-1H-pyrazol-5-yl)-boronic acidRelated Search:

1-Methyl-1H-pyrazole-5-boronic acid pinacol ester 1-METHYL-3-TRIFLUOROMETHYLPYRAZOLE-5-BORONIC ACID 1,3-DIMETHYL-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE 1-(Tetrahydro-2H-pyran-2-yl)-5-(4,4,6-trimethyl-1,3,2-dioxaborinan-2-yl)-1H-pyrazole tert-butyl isopropyl((5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazol-3-yl)methyl)carbamate 3-((tert-butyldimethylsilyloxy)methyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazole 1-Methyl-5-(4,4,6-trimethyl-1,3,2-dioxaborinan-2-yl)-1H-pyrazole 5-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole (1-Methyl-1H-pyrazol-5-yl)-boronic acid 1-(Tetrahydropyran-2-yl)-1H-pyrazole-5-boronic acid pinacol ester 1-benzyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 1-(2-Trimethylsilanylethoxymethyl)-1H-pyrazole-5-boronic acid pinacol ester 5-(5,5-DIMETHYL-1,3,2-DIOXABORINAN-2-YL)-1-METHYL-1H-PYRAZOLE tert-Butyl 5-(4,4,6-trimethyl-1,3,2-dioxaborinan-2-yl)-1H-pyrazole-1-carboxylate 5-(5,5-DIMETHYL-1,3,2-DIOXABORINAN-2-YL)-1-[[2-(TRIMETHYLSILYL)ETHOXY]METHYL]-1H-PYRAZOLE

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-5-yL

1-Methyl-1H-pyrazole-5-boronic Acid (contains varying amounts of Anhydride)

(1-Methyl-1H-pyrazol-5-yl)boronic Acid (contains varying amounts of Anhydride)

(1-Methyl-1H-pyrazol-5-yl)-boronic acid - [M0161]

720702-41-0