ChemicalBook > CAS DataBase List > (1-Methyl-1H-pyrazol-5-yl)-boronic acid
(1-Methyl-1H-pyrazol-5-yl)-boronic acid
- Product Name
- (1-Methyl-1H-pyrazol-5-yl)-boronic acid
- CAS No.
- 720702-41-0
- Chemical Name
- (1-Methyl-1H-pyrazol-5-yl)-boronic acid
- Synonyms
- -5-yL;(1-Methyl-1H-pyrazol-5-yl...;1-Methyl-pyrazole-5-boronic acid;(2-methylpyrazol-3-yl)boronic acid;(2-methyl-3-pyrazolyl)boronic acid;1-Methyl-1H-pyrazole-5-boronic acid;1-Methyl-1H-pyrazol-5-yl-5-boronic acid;(1-Methyl-1H-pyrazol-5-yl)-boronic acid;720702-41-0;BORONIC ACID, (1-METHYL-1H-PYRAZOL-5-YL)-
- CBNumber
- CB72462274
- Molecular Formula
- C4H7BN2O2
- Formula Weight
- 125.92
- MOL File
- 720702-41-0.mol
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(1-Methyl-1H-pyrazol-5-yl)-boronic acid Property
- Boiling point:
- 323.0±34.0 °C(Predicted)
- Density
- 1.23±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- pka
- 8.00±0.58(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C4H7BN2O2/c1-7-4(5(8)9)2-3-6-7/h2-3,8-9H,1H3
- InChIKey
- MGNBKNBEZGLHNF-UHFFFAOYSA-N
- SMILES
- B(C1N(C)N=CC=1)(O)O
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
TCI Chemical
- Product number
- M2680
- Product name
- (1-Methyl-1H-pyrazol-5-yl)boronic Acid (contains varying amounts of Anhydride)
- Packaging
- 1G
- Price
- $56
- Updated
- 2025/07/31
TCI Chemical
- Product number
- M2680
- Product name
- (1-Methyl-1H-pyrazol-5-yl)boronic Acid (contains varying amounts of Anhydride)
- Packaging
- 5G
- Price
- $166
- Updated
- 2025/07/31
TRC
- Product number
- M321220
- Product name
- 1-Methyl-1H-pyrazole-5-boronicAcid
- Packaging
- 5g
- Price
- $275
- Updated
- 2021/12/16
Usbiological
- Product number
- 409996
- Product name
- 1-Methyl-1H-pyrazole-5-boronic Acid
- Packaging
- 1g
- Price
- $347
- Updated
- 2021/12/16
Oakwood
- Product number
- 208723
- Product name
- 1-Methylpyrazole-5-boronicacid
- Purity
- 97%
- Packaging
- 250mg
- Price
- $12
- Updated
- 2021/12/16
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(1-Methyl-1H-pyrazol-5-yl)-boronic acid Chemical Properties,Usage,Production
Uses
1-Methyl-1H-pyrazole-5-boronic Acid acts as a reagent for the design, synthesis and evaluation of novel porcupine inhibitors featuring a fused 3-ring system based on ‘reversed’ amide scaffold.
Synthesis
930-36-9
720702-41-0
General procedure for the synthesis of 1-methyl-1H-pyrazole-5-boronic acid from 1-methylpyrazole: 1-methylpyrazole (25 mL, 0.3 mol) was dissolved in 500 mL of tetrahydrofuran (THF). The solution was then cooled to -78°C in a dry ice/isopropanol bath. After the solution temperature stabilized at -78 °C, n-butyllithium (n-BuLi, 140 mL, 0.40 mol) was slowly added dropwise through the cannula. After the dropwise addition, the reaction mixture was stirred continuously at -78 °C for 1.5 hours. Next, triisopropyl borate (280 mL, 1.2 mol) was added to the reaction system via cannula and the reaction mixture was allowed to slowly warm from -78 °C to 0 °C while stirring overnight. Upon completion of the reaction, the pH of the mixture was adjusted to 6 with 1 N hydrochloric acid (HCl).Subsequently, THF was evaporated under reduced pressure and the remaining aqueous phase was extracted with ethyl acetate (EtOAc, 2 × 100 mL). Finally, the solid was collected by filtration to afford 108 g (100% yield) of 1-methyl-1H-pyrazole-5-boronic acid as a yellow solid.
References
[1] Patent: WO2005/12254, 2005, A1. Location in patent: Page/Page column 101
[2] Journal of Medicinal Chemistry, 2010, vol. 53, # 5, p. 1923 - 1936
[3] Journal of Heterocyclic Chemistry, 2004, vol. 41, # 6, p. 931 - 939
[4] Patent: WO2004/58722, 2004, A1. Location in patent: Page 63; 62
(1-Methyl-1H-pyrazol-5-yl)-boronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (1-Methyl-1H-pyrazol-5-yl)-boronic acid manufacturers
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- (1-Methyl-1H-pyrazol-5-yl)-boronic acid 720702-41-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- (1-Methyl-1H-pyrazol-5-yl)-boronic acid 720702-41-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09
Career Henan Chemical Co
- Product
- (1-Methyl-1H-pyrazol-5-yl)-boronic acid 720702-41-0
- Price
- US $500.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2018-08-04
720702-41-0, (1-Methyl-1H-pyrazol-5-yl)-boronic acidRelated Search:
1-Methyl-1H-pyrazole-5-boronic acid pinacol ester
1-METHYL-3-TRIFLUOROMETHYLPYRAZOLE-5-BORONIC ACID
1,3-DIMETHYL-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE
1-(Tetrahydro-2H-pyran-2-yl)-5-(4,4,6-trimethyl-1,3,2-dioxaborinan-2-yl)-1H-pyrazole
tert-butyl isopropyl((5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazol-3-yl)methyl)carbamate
3-((tert-butyldimethylsilyloxy)methyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazole
1-Methyl-5-(4,4,6-trimethyl-1,3,2-dioxaborinan-2-yl)-1H-pyrazole
5-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole
(1-Methyl-1H-pyrazol-5-yl)-boronic acid
1-(Tetrahydropyran-2-yl)-1H-pyrazole-5-boronic acid pinacol ester
1-benzyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
1-(2-Trimethylsilanylethoxymethyl)-1H-pyrazole-5-boronic acid pinacol ester
5-(5,5-DIMETHYL-1,3,2-DIOXABORINAN-2-YL)-1-METHYL-1H-PYRAZOLE
tert-Butyl 5-(4,4,6-trimethyl-1,3,2-dioxaborinan-2-yl)-1H-pyrazole-1-carboxylate
5-(5,5-DIMETHYL-1,3,2-DIOXABORINAN-2-YL)-1-[[2-(TRIMETHYLSILYL)ETHOXY]METHYL]-1H-PYRAZOLE