PIPERLONGUMINE
- Product Name
- PIPERLONGUMINE
- CAS No.
- 20069-09-4
- Chemical Name
- PIPERLONGUMINE
- Synonyms
- ong;PPLGM;umine;PiperL;ongumine;acryloyl);Piplartin;PIPLARTINE;PIPERLONGUMIN;Piperlorgumia
- CBNumber
- CB7246450
- Molecular Formula
- C17H19NO5
- Formula Weight
- 317.34
- MOL File
- 20069-09-4.mol
PIPERLONGUMINE Property
- Melting point:
- 124°C
- Boiling point:
- 475.6±45.0 °C(Predicted)
- Density
- 1.223±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: ≥5mg/mL at warmed to 60°C
- form
- powder
- pka
- -1.88±0.20(Predicted)
- color
- white to beige
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
- LogP
- 2.340 (est)
Safety
- WGK Germany
- 3
- RTECS
- UU7785850
- HS Code
- 2932209090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H320Causes eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML0221
- Product name
- Piperlongumine
- Purity
- ≥97% (HPLC)
- Packaging
- 5mg
- Price
- $77.4
- Updated
- 2024/03/01
- Product number
- 528124
- Product name
- Piperlongumine
- Packaging
- 25mg
- Price
- $85.2
- Updated
- 2024/03/01
- Product number
- P2361
- Product name
- Piperlongumine
- Purity
- >97.0%(HPLC)
- Packaging
- 25mg
- Price
- $98
- Updated
- 2024/03/01
- Product number
- P2361
- Product name
- Piperlongumine
- Purity
- >97.0%(HPLC)
- Packaging
- 100mg
- Price
- $313
- Updated
- 2021/12/16
- Product number
- 11006
- Product name
- Piperlongumine
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $44
- Updated
- 2024/03/01
PIPERLONGUMINE Chemical Properties,Usage,Production
Description
A piperidinone alkaloid present in Piper longum, the structure has been shown to be N-(3:4:5-trimethoxycinnamoyl)-Lls-piperidin-2-one. In the plant, the base occurs mainly in the roots.
Uses
Piperlongumine has been used to study the regulation of protein regulator of cytokinesis 1 (PRC1) expression. It has also been used to investigate its anti-tumor effects on human melanoma cells in vitro.
Uses
anti-asthma, antibronchitis
Uses
Piperlongumine (PL), a new alkaloid abundantly present in Piper longum fruits strongly inhibited platelet cell aggregation. It may have anti-cancer properties. It selectively targets and kills cancer cells but leaving normal cells unharmed.
Definition
ChEBI: Piplartine is a member of cinnamamides and a dicarboximide.
General Description
Piperlongumine is an alkaloid, which is extracted from Piper longum Linn. It exhibits anti-atherosclerotic, anxiolytic, antidiabetic, antidepressant, antibacterial, anti-platelet, aggregation, anxiolytic and anti-inflammatory properties. Piperlongumine prevents the production of tumor necrosis factor-α and interleukin-6. It blocks the activation of nuclear factor-κB (NF-κB) against proinflammatory responses. Piperlongumine inhibits plaque formation and inhibits vascular smooth muscle cell migration. It is used to treat cough, respiratory infections and stomach-ache.
Biochem/physiol Actions
Piperlongumine selectively kills cancer cells regardless of p53 status without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1). It increases the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells with little effect on either rapidly or slowly dividing primary normal cells. Piperlongumine showed significant antitumour effects in a variety of mouse tumour models and inhibited growth of spontaneously formed malignant breast tumours and their associated metastases.
target
P450 (e.g. CYP17) | Antifection
References
Chatterjee, Dutta., Tetrahedron, 23, 1769 (1967)
PIPERLONGUMINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from PIPERLONGUMINE manufacturers
- Product
- PIPERLONGUMINE 20069-09-4
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 99
- Supply Ability
- 5000
- Release date
- 2024-12-11
- Product
- Piplartine powder ;Piperlongumine 20069-09-4
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 100kgs
- Release date
- 2021-05-23
- Product
- PIPERLONGUMINE 20069-09-4
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100 mt
- Release date
- 2024-10-29