TERT-BUTYL (4-FLUOROPIPERIDIN-4-YL)METHYLCARBAMATE
- Product Name
- TERT-BUTYL (4-FLUOROPIPERIDIN-4-YL)METHYLCARBAMATE
- CAS No.
- 871022-62-7
- Chemical Name
- TERT-BUTYL (4-FLUOROPIPERIDIN-4-YL)METHYLCARBAMATE
- Synonyms
- 4-Fluoro-4-(Boc-aminomethyl)piperidine;4-(Boc-aMinoMethyl)-4-fluoropiperidine;TERT-BUTYL (4-FLUOROPIPERIDIN-4-YL)METHYLCARBAMATE;tert-butyl N-[(4-fluoropiperidin-4-yl)methyl]carbamate;tert-butyl N-(4-fluoro-4-piperidyl)-N-methyl-carbamate;tert-?Butyl (4-?Fluoro-?4-?piperidinyl)?methylcarbamate;4-[(tert-Butoxycarbonylamino)methyl]-4-fluoropiperidine;tert-butyl (4-Fluoropiperidin-4-yl)methylcarbamate hydrochloride;[(4-Fluoro-4-piperidinyl)methyl]carbamic acid 1,1-dimethylethyl ester;Carbamic acid, [(4-fluoro-4-piperidinyl)methyl]-, 1,1-dimethylethyl ester (9CI)
- CBNumber
- CB72468195
- Molecular Formula
- C11H21FN2O2
- Formula Weight
- 232.29
- MOL File
- 871022-62-7.mol
TERT-BUTYL (4-FLUOROPIPERIDIN-4-YL)METHYLCARBAMATE Property
- Boiling point:
- 324.8±27.0 °C(Predicted)
- Density
- 1.07±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C, protect from light
- pka
- 12.72±0.46(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B809608
- Product name
- tert-Butyl(4-Fluoro-4-piperidinyl)methylcarbamate
- Packaging
- 100mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- HCH0419602
- Product name
- TERT-BUTYL N-[(4-FLUOROPIPERIDIN-4-YL)METHYL]CARBAMATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $450.45
- Updated
- 2021/12/16
- Product number
- 4H56-3-7Q
- Product name
- tert-Butyl N-[(4-fluoropiperidin-4-yl)methyl]carbamate
- Purity
- 97.0%
- Packaging
- 250mg
- Price
- $490
- Updated
- 2021/12/16
- Product number
- 122027
- Product name
- 4-(Boc-aminomethyl)-4-fluoropiperidine
- Purity
- 97.0%
- Packaging
- 1g
- Price
- $650
- Updated
- 2021/12/16
- Product number
- 4H56-3-7Q
- Product name
- tert-Butyl N-[(4-fluoropiperidin-4-yl)methyl]carbamate
- Purity
- 97.0%
- Packaging
- 1g
- Price
- $1490
- Updated
- 2021/12/16
TERT-BUTYL (4-FLUOROPIPERIDIN-4-YL)METHYLCARBAMATE Chemical Properties,Usage,Production
Uses
tert-?Butyl (4-?Fluoro-?4-?piperidinyl)?methylcarbamate is a reagent used in the preparation of cyanophenylglycine derivatives which may act as reversible inhibitors of lysine demethylase 1 which is involved in the differentiation of leukemia stem cells in ACM.
Synthesis
871022-60-5
871022-62-7
N-benzoyl-4-tert-butoxycarbonylaminomethyl-4-fluoropiperidine (the product of Step 3 of Example 15, 4.42 g, 13.1 mmol) was used as a raw material and reacted with NaOH (2.62 g, 65.5 mmol) at reflux in a mixed solvent of H2O (9.00 mL) and ethanol (90.0 mL) for 15 hours. After completion of the reaction, the mixture was concentrated in vacuum. Water and chloroform were added to the concentrated residue and the organic layer was separated. The organic layer was dried with magnesium sulfate and concentrated under reduced pressure to remove the solvent. The resulting solid was recrystallized by hexane-CH2Cl2 mixed solvent to give 1.77 g (58% yield) of the target product ((4-fluoropiperidin-4-yl)methyl)carbamic acid tert-butyl ester as a colorless solid. Mass spectrum (ESI) m/z: 233 (M + H)+. 1H NMR (CDCl3) δ 4.93 (1H, m), 3.30 (2H, dd, J = 21.5,6.3Hz), 2.91 (4H, m), 1.88-1.34 (4H, m), 1.45 (9H, s). No signal corresponding to the amino group was observed.
References
[1] Patent: US2005/277671, 2005, A1. Location in patent: Page/Page column 38
[2] Patent: US2006/194842, 2006, A1. Location in patent: Page/Page column 37
TERT-BUTYL (4-FLUOROPIPERIDIN-4-YL)METHYLCARBAMATE Preparation Products And Raw materials
Raw materials
Preparation Products
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