ChemicalBook > CAS DataBase List > Methyl 4-chloro-6-methylnicotinate

Methyl 4-chloro-6-methylnicotinate

Product Name
Methyl 4-chloro-6-methylnicotinate
CAS No.
53277-47-7
Chemical Name
Methyl 4-chloro-6-methylnicotinate
Synonyms
Methyl 4-chloro-6-methylnicotinate;Methyl 2-chloro-6-methylnicotinate;METHYL6-METHYL-2-CHLOROPYRIDINE-3-CARBOXYLATE;2-Chloro-6-methyl-3-pyridinecarboxylic acid methyl ester;3-Pyridinecarboxylic acid, 2-chloro-6-Methyl-, Methyl ester;Methyl 2-chloro-6-methylpyridine-3-carboxylate, 2-Chloro-3-(methoxycarbonyl)-6-methylpyridine
CBNumber
CB72470208
Molecular Formula
C8H8ClNO2
Formula Weight
185.61
MOL File
53277-47-7.mol
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Methyl 4-chloro-6-methylnicotinate Property

Melting point:
27-28℃
Boiling point:
253℃
Density 
1.247
Flash point:
107℃
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
-0.43±0.10(Predicted)
Appearance
Colorless to off-white <27°C Solid,>28°C Liquid
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
M340420
Product name
Methyl2-Chloro-6-methylnicotinate
Packaging
500mg
Price
$155
Updated
2021/12/16
SynQuest Laboratories
Product number
4H23-5-X7
Product name
Methyl 2-chloro-6-methylnicotinate
Packaging
1g
Price
$87
Updated
2021/12/16
AK Scientific
Product number
7556AB
Product name
Methyl2-chloro-6-methylnicotinate
Packaging
1g
Price
$131
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0369186
Product name
METHYL-2-CHLORO-6-METHYLNICOTINATE
Purity
95.00%
Packaging
5MG
Price
$496.94
Updated
2021/12/16
AK Scientific
Product number
7556AB
Product name
Methyl2-chloro-6-methylnicotinate
Packaging
25g
Price
$797
Updated
2021/12/16
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Methyl 4-chloro-6-methylnicotinate Chemical Properties,Usage,Production

Synthesis

67-56-1

30529-70-5

53277-47-7

The general procedure for the synthesis of methyl 2-chloro-6-methylpyridine-3-carboxylate from methanol and 2-chloro-6-methylnicotinic acid was as follows: a. Oxalyl chloride (9.3 mL) was slowly added to a solution of dichloromethane (500 mL) containing 2-chloro-6-methylnicotinic acid (9 g). The reaction mixture was stirred at room temperature for 30 min before the solvent was removed by concentration under reduced pressure to give the crude product. Subsequently, the crude product was dissolved in methanol (500 mL) and processed at 0 °C with stirring. After the reaction mixture was continued to be stirred at room temperature overnight, the solvent was again removed by concentration under reduced pressure to give the residue. The residue was diluted with water and ethyl acetate (EA), neutralized with saturated aqueous sodium bicarbonate solution and subsequently extracted three times with ethyl acetate. The organic layers were combined, washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give methyl 2-chloro-6-methylpyridine-3-carboxylate (9.7 g, 99% yield). The product was characterized by 1H NMR (400 MHz, chloroform-d): δ 2.60 (s, 3H), 3.95 (s, 3H), 7.17 (d, J = 7.8 Hz, 1H), 8.09 (d, J = 7.8 Hz, 1H).

References

[1] Patent: US2011/152312, 2011, A1. Location in patent: Page/Page column 35
[2] Patent: WO2009/100171, 2009, A1. Location in patent: Page/Page column 82
[3] Patent: US2010/144760, 2010, A1. Location in patent: Page/Page column 30; 31
[4] Patent: WO2010/72722, 2010, A1. Location in patent: Page/Page column 50
[5] Patent: WO2006/25783, 2006, A1. Location in patent: Page/Page column 65-66

Methyl 4-chloro-6-methylnicotinate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Methyl 4-chloro-6-methylnicotinate manufacturers

Career Henan Chemical Co
Product
Methyl 4-chloro-6-methylnicotinate 53277-47-7
Price
US $1.00/KG
Min. Order
1IU
Purity
99%
Supply Ability
200kg
Release date
2020-01-02

53277-47-7, Methyl 4-chloro-6-methylnicotinateRelated Search:

Methyl nicotinate Methyl 6-methylnicotinate

  • Methyl 4-chloro-6-methylnicotinate
  • 2-Chloro-6-methyl-3-pyridinecarboxylic acid methyl ester
  • Methyl 2-chloro-6-methylnicotinate
  • 3-Pyridinecarboxylic acid, 2-chloro-6-Methyl-, Methyl ester
  • Methyl 2-chloro-6-methylpyridine-3-carboxylate, 2-Chloro-3-(methoxycarbonyl)-6-methylpyridine
  • METHYL6-METHYL-2-CHLOROPYRIDINE-3-CARBOXYLATE
  • 53277-47-7