N-[4-[[(2-Amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid disodium salt

Product Name: N-[4-[[(2-Amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid disodium salt
CAS No.: 163254-40-8
Chemical Name: N-[4-[[(2-Amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid disodium salt
Synonyms: CL143;Disodium folinate;Disodium levofolinate;Folinic acid disodium;Levoleucovorin disodium;(2S)-2-[[4-[[(6S)-2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]pentanedioate;N-[4-[[(2-Amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid disodium salt;N-[4-[[(2-Amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid disodium salt USP/EP/BP
CBNumber: CB72470349
Molecular Formula: C20H21N7Na2O7
Formula Weight: 517.13
MOL File: 163254-40-8.mol

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N-[4-[[(2-Amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid disodium salt Property

storage temp.: Sealed in dry,Room Temperature

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FD153143
Product name: Disodiumfolinate
Packaging: 2mg
Price: $59
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD153143
Product name: Disodiumfolinate
Packaging: 5mg
Price: $117
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD153143
Product name: Disodiumfolinate
Packaging: 10mg
Price: $203
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD153143
Product name: Disodiumfolinate
Packaging: 25mg
Price: $405
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0019497
Product name: DISODIUM FOLINATE
Purity: 95.00%
Packaging: 5MG
Price: $500.97
Updated: 2021/12/16

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N-[4-[[(2-Amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid disodium salt Chemical Properties,Usage,Production

Uses

Folinic acid (Leucovorin) disodium is a biological folic acid and is a forms of vitamin B9. Folinic acid disodium is generally administered along with Methotrexate.html" class="link-product" target="_blank">Methotrexate (MTX) (HY-14519) as a rescue agent to decrease MTX-induced toxicity. Folinic acid disodium and Sfluorouracil adjuvant chemotherapy shows effective in colon carcinoma[1][2][3].

in vivo

Folinic acid disodium (7.0 mg/kg; intraperitoneal injection; every second day; for 3 weeks; Balb/c young growing male mice) treatment following Methotrexate (MTX) administration appears to reverse this growth inhibition (Chronic administration of MTX induces suppression of skeletal growth in mice)^[2].

Animal Model:	24 Balb/c young growing male mice aged 3 weeks (11.88 ± 0.25 g)^[2]
Dosage:	7.0 mg/kg
Administration:	Intraperitoneal injection; every second day; for 3 weeks
Result:	Following MTX administration appears to reverse this growth inhibition.

IC 50

Human Endogenous Metabolite

References

[1] Keshava, C., et al., Inhibition of methotrexate-induced chromosomal damage by folinic acid in V79 cells. Mutat Res, 1998. 397(2): p. 221-8. DOI:10.1016/s0027-5107(97)00216-9
[2] Iqbal MP, et al. Effect of methotrexate and folinic acid on skeletal growth in mice. Acta Paediatr. 2003 Dec;92(12):1438-44. PMID:14971796
[3] Francini G, et al. Folinic acid and 5-fluorouracil as adjuvant chemotherapy in colon cancer. Gastroenterology. 1994 Apr;106(4):899-906. DOI:10.1016/0016-5085(94)90748-x

N-[4-[[(2-Amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid disodium salt Preparation Products And Raw materials

Raw materials

Preparation Products

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N-[4-[[(2-Amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid disodium salt Suppliers

China 23 United Kingdom 1 United States 3 Global 27

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

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TargetMol Chemicals Inc.

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Hubei xin bonus chemical co. LTD

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Chongqing Chemdad Co., Ltd

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View Lastest Price from N-[4-[[(2-Amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid disodium salt manufacturers

Career Henan Chemical Co

Product: N-[4-[[(2-Amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid disodium salt 163254-40-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1tons
Release date: 2018-08-08

163254-40-8, N-[4-[[(2-Amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid disodium saltRelated Search:

Folic acid Folinic acid

Disodium folinate

N-[4-[[(2-Amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid disodium salt

CL143

(2S)-2-[[4-[[(6S)-2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]pentanedioate

N-[4-[[(2-Amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid disodium salt USP/EP/BP

Disodium levofolinate

Levoleucovorin disodium

Folinic acid disodium

163254-40-8

C20H21N7Na2O7