N-[4-[[(2-Amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid disodium salt
- Product Name
- N-[4-[[(2-Amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid disodium salt
- CAS No.
- 163254-40-8
- Chemical Name
- N-[4-[[(2-Amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid disodium salt
- Synonyms
- CL143;Disodium folinate;Disodium levofolinate;Folinic acid disodium;Levoleucovorin disodium;(2S)-2-[[4-[[(6S)-2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]pentanedioate;N-[4-[[(2-Amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid disodium salt;N-[4-[[(2-Amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid disodium salt USP/EP/BP
- CBNumber
- CB72470349
- Molecular Formula
- C20H21N7Na2O7
- Formula Weight
- 517.13
- MOL File
- 163254-40-8.mol
N-[4-[[(2-Amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid disodium salt Property
- storage temp.
- Sealed in dry,Room Temperature
N-Bromosuccinimide Price
- Product number
- FD153143
- Product name
- Disodiumfolinate
- Packaging
- 2mg
- Price
- $59
- Updated
- 2021/12/16
- Product number
- FD153143
- Product name
- Disodiumfolinate
- Packaging
- 5mg
- Price
- $117
- Updated
- 2021/12/16
- Product number
- FD153143
- Product name
- Disodiumfolinate
- Packaging
- 10mg
- Price
- $203
- Updated
- 2021/12/16
- Product number
- FD153143
- Product name
- Disodiumfolinate
- Packaging
- 25mg
- Price
- $405
- Updated
- 2021/12/16
- Product number
- API0019497
- Product name
- DISODIUM FOLINATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.97
- Updated
- 2021/12/16
N-[4-[[(2-Amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid disodium salt Chemical Properties,Usage,Production
Uses
Folinic acid (Leucovorin) disodium is a biological folic acid and is a forms of vitamin B9. Folinic acid disodium is generally administered along with Methotrexate.html" class="link-product" target="_blank">Methotrexate (MTX) (HY-14519) as a rescue agent to decrease MTX-induced toxicity. Folinic acid disodium and Sfluorouracil adjuvant chemotherapy shows effective in colon carcinoma[1][2][3].
in vivo
Folinic acid disodium (7.0 mg/kg; intraperitoneal injection; every second day; for 3 weeks; Balb/c young growing male mice) treatment following Methotrexate (MTX) administration appears to reverse this growth inhibition (Chronic administration of MTX induces suppression of skeletal growth in mice)[2].
| Animal Model: | 24 Balb/c young growing male mice aged 3 weeks (11.88 ± 0.25 g)[2] |
| Dosage: | 7.0 mg/kg |
| Administration: | Intraperitoneal injection; every second day; for 3 weeks |
| Result: | Following MTX administration appears to reverse this growth inhibition. |
IC 50
Human Endogenous Metabolite
References
[1] Keshava, C., et al., Inhibition of methotrexate-induced chromosomal damage by folinic acid in V79 cells. Mutat Res, 1998. 397(2): p. 221-8. DOI:10.1016/s0027-5107(97)00216-9
[2] Iqbal MP, et al. Effect of methotrexate and folinic acid on skeletal growth in mice. Acta Paediatr. 2003 Dec;92(12):1438-44. PMID:14971796
[3] Francini G, et al. Folinic acid and 5-fluorouracil as adjuvant chemotherapy in colon cancer. Gastroenterology. 1994 Apr;106(4):899-906. DOI:10.1016/0016-5085(94)90748-x
N-[4-[[(2-Amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid disodium salt Preparation Products And Raw materials
Raw materials
Preparation Products
N-[4-[[(2-Amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid disodium salt Suppliers
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- sales@carbosynth.com
- Country
- United Kingdom
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- 6005
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- Product
- N-[4-[[(2-Amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid disodium salt 163254-40-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1tons
- Release date
- 2018-08-08