Methyl 2,6-dichloro-4-cyanobenzoate
- Product Name
- Methyl 2,6-dichloro-4-cyanobenzoate
- CAS No.
- 409127-32-8
- Chemical Name
- Methyl 2,6-dichloro-4-cyanobenzoate
- Synonyms
- 2，6-dichloro-4-cyanobenzoic acid;Methyl 2,6-dichloro-4-cyanobenzoate;Methyl 2,6-difluoro-4-Cyanobenzoate;Benzoic acid, 2,6-dichloro-4-cyano-, methyl ester
- CBNumber
- CB72470844
- Molecular Formula
- C9H5Cl2NO2
- Formula Weight
- 230.05
- MOL File
- 409127-32-8.mol
Methyl 2,6-dichloro-4-cyanobenzoate Property
- Boiling point:
- 319.6±42.0 °C(Predicted)
- Density
- 1.45
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- White to off-white Solid
N-Bromosuccinimide Price
- Product number
- 097913
- Product name
- Methyl 2,6-dichloro-4-cyanobenzoate
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $439
- Updated
- 2021/12/16
- Product number
- 097913
- Product name
- Methyl 2,6-dichloro-4-cyanobenzoate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $975
- Updated
- 2021/12/16
- Product number
- A487149
- Product name
- Methyl2,6-dichloro-4-cyanobenzoate
- Purity
- 98%
- Packaging
- 100mg
- Price
- $86
- Updated
- 2021/12/16
- Product number
- A487149
- Product name
- Methyl2,6-dichloro-4-cyanobenzoate
- Purity
- 98%
- Packaging
- 250mg
- Price
- $152
- Updated
- 2021/12/16
- Product number
- A487149
- Product name
- Methyl2,6-dichloro-4-cyanobenzoate
- Purity
- 98%
- Packaging
- 1g
- Price
- $428
- Updated
- 2021/12/16
Methyl 2,6-dichloro-4-cyanobenzoate Chemical Properties,Usage,Production
Synthesis
409127-31-7
409127-32-8
Step a: Synthesis of methyl 2,6-dichloro-4-cyanobenzoate Methyl 4-carbamoyl-2,6-dichlorobenzoate (100 mg, 0.4 mmol) was dissolved in pyridine (2 mL) and trifluoroacetic anhydride (0.11 mL, 0.8 mmol) was added slowly and dropwise at 0 °C. The reaction mixture was gradually warmed to room temperature and stirred continuously for 1 hour. Upon completion of the reaction, the mixture was poured into pre-cooled ice water, the precipitated solid was filtered, washed thoroughly with cold water and dried to afford methyl 2,6-dichloro-4-cyanobenzoate (55 mg, 88% yield) as an off-white solid.
References
[1] Patent: WO2012/160464, 2012, A1. Location in patent: Page/Page column 77-78
[2] Patent: US2014/155398, 2014, A1. Location in patent: Paragraph 0468
[3] Patent: US2010/317643, 2010, A1. Location in patent: Page/Page column 101
[4] Journal of Medicinal Chemistry, 2013, vol. 56, # 11, p. 4521 - 4536
Methyl 2,6-dichloro-4-cyanobenzoate Preparation Products And Raw materials
Raw materials
Preparation Products
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