ChemicalBook > CAS DataBase List > 2-Chlorothieno[3,2-d]pyrimidine

2-Chlorothieno[3,2-d]pyrimidine

Product Name
2-Chlorothieno[3,2-d]pyrimidine
CAS No.
1119280-68-0
Chemical Name
2-Chlorothieno[3,2-d]pyrimidine
Synonyms
2-Chlorothieno[3,2-d]pyrimidine;Thieno[3,2-d]pyrimidine, 2-chloro-;2-Chlorothieno[3,2-d]pyrimidine ISO 9001：2015 REACH
CBNumber
CB72471265
Molecular Formula
C6H3ClN2S
Formula Weight
170.62
MOL File
1119280-68-0.mol
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2-Chlorothieno[3,2-d]pyrimidine Property

Melting point:
165-166℃
Density 
1.531
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
solid
pka
-0.06±0.40(Predicted)
Appearance
White to off-white Solid
InChI
InChI=1S/C6H3ClN2S/c7-6-8-3-5-4(9-6)1-2-10-5/h1-3H
InChIKey
QKRVOGZPQVCVPZ-UHFFFAOYSA-N
SMILES
C1(Cl)=NC=C2SC=CC2=N1
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Safety

HazardClass 
IRRITANT
HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
C375595
Product name
2-Chlorothieno[3,2-d]pyrimidine
Packaging
100mg
Price
$65
Updated
2021/12/16
Apolloscientific
Product number
OR963899
Product name
2-Chlorothieno[3,2-d]pyrimidine
Purity
98%
Packaging
250mg
Price
$100
Updated
2021/12/16
ChemScene
Product number
CS-W006642
Product name
2-Chlorothieno[3,2-d]pyrimidine
Purity
99.21%
Packaging
1g
Price
$120
Updated
2021/12/16
SynQuest Laboratories
Product number
7H70-5-1Q
Product name
2-Chlorothieno[3,2-d]pyrimidine
Purity
98%
Packaging
250mg
Price
$160
Updated
2021/12/16
Apolloscientific
Product number
OR963899
Product name
2-Chlorothieno[3,2-d]pyrimidine
Purity
98%
Packaging
1g
Price
$235
Updated
2021/12/16
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2-Chlorothieno[3,2-d]pyrimidine Chemical Properties,Usage,Production

Synthesis

16234-14-3

1119280-68-0

GENERAL STEPS: 2,4-Dichlorothieno[3,2-d]pyrimidine (19 g, 58 mmol) was dissolved in a solvent mixture of ethanol (25 mL) and ethyl acetate (25 mL). To this solution was added sodium bicarbonate (1.1 g, 13.1 mmol) followed by 10% palladium carbon catalyst (0.206 g). The reaction mixture was stirred under hydrogen atmosphere for 5 h. The reaction progress was monitored by liquid chromatography-mass spectrometry (LC-MS) to confirm the formation of 2-chlorothieno[3,2-d]pyrimidine. Upon completion of the reaction, the mixture was filtered through diatomaceous earth to remove the catalyst and the filtrate was concentrated under reduced pressure to afford the off-white solid product 2-chlorothieno[3,2-d]pyrimidine (0.990 g, quantitative yield). The structure of the product was confirmed by 1H NMR (CDCl3): δ 9.17 (s, 1H), 8.16-8.12 (d, 1H), 7.55-7.51 (d, 1H).

References

[1] Patent: WO2011/79231, 2011, A1. Location in patent: Page/Page column 82
[2] Patent: WO2009/62258, 2009, A1. Location in patent: Page/Page column 91
[3] ACS Medicinal Chemistry Letters, 2011, vol. 2, # 2, p. 154 - 159
[4] Patent: WO2012/78859, 2012, A2. Location in patent: Page/Page column 59
[5] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 7, p. 2113 - 2122

2-Chlorothieno[3,2-d]pyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Chlorothieno[3,2-d]pyrimidine Suppliers

China 101 Germany 1 India 1 United Kingdom 2 United States 8 Global 113
Suzhou Zehou Biotechnology Co. , Ltd.
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0512-68716880 19984816880
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18075373931
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sales@growingchem.com
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China
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Shanghai Leiming Medical Technology Co., LTD
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13761371720
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zhangleitao111@sina.com
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Shangchem Co., Ltd.
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+86-21-68182121
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+86-21-68182121
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Pure Chemistry Scientific Inc.
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001-857-928-2050 or 1-888-588-9418
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ZhengZhou HuaWen Chemical Co.Ltd
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0370-2785118 17550508557
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QQ：3470079902
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NovoChemy Ltd.
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Germany
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View Lastest Price from 2-Chlorothieno[3,2-d]pyrimidine manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
2-Chlorothieno[3,2-d]pyrimidine 1119280-68-0
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-25
Career Henan Chemical Co
Product
2-Chlorothieno[3,2-d]pyrimidine 1119280-68-0
Price
US $1.00/KG
Min. Order
1KG
Purity
95-99%
Supply Ability
1ton
Release date
2020-01-08

1119280-68-0, 2-Chlorothieno[3,2-d]pyrimidineRelated Search:

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  • 2-Chlorothieno[3,2-d]pyrimidine ISO 9001：2015 REACH
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