ETHYL 2-CHLOROTHIAZOLE-5-CARBOXYLATE
- Product Name
- ETHYL 2-CHLOROTHIAZOLE-5-CARBOXYLATE
- CAS No.
- 81449-93-6
- Chemical Name
- ETHYL 2-CHLOROTHIAZOLE-5-CARBOXYLATE
- Synonyms
- Ethyl 2-chloro-5-thiazolecarboxylate;ETHYL 2-CHLOROTHIAZOLE-5-CARBOXYLATE;ethyl 2-chloro-1,3-thiazole-5-carboxylate;2-Chlorothiazole-5-carboxylic acid ethyl ester;2-Chloro-5-thiazolecarboxylic acid ethyl ester;5-Thiazolecarboxylicacid, 2-chloro-, ethyl ester
- CBNumber
- CB1804128
- Molecular Formula
- C6H6ClNO2S
- Formula Weight
- 191.64
- MOL File
- 81449-93-6.mol
ETHYL 2-CHLOROTHIAZOLE-5-CARBOXYLATE Property
- Boiling point:
- 283.9±32.0 °C(Predicted)
- Density
- 1.383±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- Chloroform; Dichloromethane; DMSO; Ethyl Acetate
- pka
- -0.98±0.10(Predicted)
- form
- Oil
- color
- Colorless
- CAS DataBase Reference
- 81449-93-6(CAS DataBase Reference)
Safety
- HS Code
- 2934100090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- E903550
- Product name
- Ethyl2-Chlorothiazole-5-carboxylate
- Packaging
- 250mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 072426
- Product name
- Ethyl 2-chlorothiazole-5-carboxylate
- Purity
- 95+%
- Packaging
- 5g
- Price
- $58
- Updated
- 2021/12/16
- Product number
- P000121640
- Product name
- Ethyl 2-chlorothiazole-5-carboxylate
- Purity
- 97%
- Packaging
- 10g
- Price
- $61
- Updated
- 2021/12/16
- Product number
- 072426
- Product name
- Ethyl 2-chlorothiazole-5-carboxylate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $19
- Updated
- 2021/12/16
- Product number
- P000121640
- Product name
- Ethyl 2-chlorothiazole-5-carboxylate
- Purity
- 97%
- Packaging
- 5g
- Price
- $34
- Updated
- 2021/12/16
ETHYL 2-CHLOROTHIAZOLE-5-CARBOXYLATE Chemical Properties,Usage,Production
Uses
Ethyl 2-chlorothiazole-5-carboxylate is an intermediate in synthesizing 2-Chloro-5-thiazolecarboxylic Acid (C411465). It was studied as one of the metabolites of thiamethoxam, clothianidin, and dinotefuran in mice.
Synthesis
32955-21-8
81449-93-6
The general procedure for the synthesis of ethyl 2-chloro-1,3-thiazole-5-carboxylate from ethyl 2-aminothiazole-5-carboxylate was as follows: ethyl 2-aminothiazole-5-carboxylate (1.0 g, 6.35 mmol) was dissolved in a solvent mixture of acetonitrile (10 mL) and tetrahydrofuran (10 mL) at 23 °C. The solution was then slowly added to a mixture of acetonitrile (10 mL) and tetrahydrofuran (10 mL) containing butyl nitrite (1.3 mL, 9.52 mmol) and cuprous chloride (1.0 g, 7.6 mmol). The reaction mixture was to be heated at 65°C until thin layer chromatography (TLC) analysis (unfolding agent was 40% ethyl acetate-hexane) showed complete consumption of the raw materials. After completion of the reaction, the mixture was cooled to room temperature and extracted by partitioning between water and ethyl acetate. The organic layer was collected, concentrated under reduced pressure and finally purified by fast silica gel column chromatography with 20% ethyl acetate-hexane as eluent to afford the target product ethyl 2-chloro-1,3-thiazole-5-carboxylate (0.49 g, 40% yield).
References
[1] Patent: EP2615092, 2013, A1. Location in patent: Paragraph 0095; 0097
[2] Helvetica Chimica Acta, 1954, vol. 37, p. 2057,2064
[3] Helvetica Chimica Acta, 1944, vol. 27, p. 1432,1433
[4] Patent: WO2004/80996, 2004, A1. Location in patent: Page 26-27; 47
ETHYL 2-CHLOROTHIAZOLE-5-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from ETHYL 2-CHLOROTHIAZOLE-5-CARBOXYLATE manufacturers
- Product
- ETHYL 2-CHLOROTHIAZOLE-5-CARBOXYLATE 81449-93-6
- Price
- US $6.68/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg-1000kg
- Release date
- 2020-01-10